ID   B3RXL2_TRIAD            Unreviewed;       523 AA.
AC   B3RXL2;
DT   02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   02-SEP-2008, sequence version 1.
DT   27-MAR-2024, entry version 71.
DE   RecName: Full=Importin subunit alpha {ECO:0000256|PIRNR:PIRNR005673};
GN   ORFNames=TRIADDRAFT_25701 {ECO:0000313|EMBL:EDV24447.1};
OS   Trichoplax adhaerens (Trichoplax reptans).
OC   Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC   Trichoplax.
OX   NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV24447.1, ECO:0000313|Proteomes:UP000009022};
RN   [1] {ECO:0000313|EMBL:EDV24447.1, ECO:0000313|Proteomes:UP000009022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV24447.1,
RC   ECO:0000313|Proteomes:UP000009022};
RX   PubMed=18719581; DOI=10.1038/nature07191;
RA   Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA   Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA   Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA   Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA   Rokhsar D.S.;
RT   "The Trichoplax genome and the nature of placozoans.";
RL   Nature 454:955-960(2008).
CC   -!- SIMILARITY: Belongs to the importin alpha family.
CC       {ECO:0000256|ARBA:ARBA00010394, ECO:0000256|PIRNR:PIRNR005673}.
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DR   EMBL; DS985245; EDV24447.1; -; Genomic_DNA.
DR   RefSeq; XP_002112337.1; XM_002112301.1.
DR   AlphaFoldDB; B3RXL2; -.
DR   STRING; 10228.B3RXL2; -.
DR   EnsemblMetazoa; TriadT25701; TriadP25701; TriadG25701.
DR   GeneID; 6753982; -.
DR   KEGG; tad:TRIADDRAFT_25701; -.
DR   CTD; 6753982; -.
DR   eggNOG; KOG0166; Eukaryota.
DR   HOGENOM; CLU_018084_6_0_1; -.
DR   InParanoid; B3RXL2; -.
DR   OMA; EMIQMLY; -.
DR   OrthoDB; 916229at2759; -.
DR   PhylomeDB; B3RXL2; -.
DR   Proteomes; UP000009022; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0061608; F:nuclear import signal receptor activity; IBA:GO_Central.
DR   GO; GO:0008139; F:nuclear localization sequence binding; IBA:GO_Central.
DR   GO; GO:0006607; P:NLS-bearing protein import into nucleus; IBA:GO_Central.
DR   Gene3D; 1.20.5.690; Importin-alpha, importin-beta-binding domain; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR032413; Arm_3.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR002652; Importin-a_IBB.
DR   InterPro; IPR036975; Importin-a_IBB_sf.
DR   InterPro; IPR024931; Importin_alpha.
DR   PANTHER; PTHR23316; IMPORTIN ALPHA; 1.
DR   PANTHER; PTHR23316:SF71; IMPORTIN SUBUNIT ALPHA; 1.
DR   Pfam; PF00514; Arm; 7.
DR   Pfam; PF16186; Arm_3; 1.
DR   Pfam; PF01749; IBB; 1.
DR   PIRSF; PIRSF005673; Importin_alpha; 1.
DR   SMART; SM00185; ARM; 8.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS50176; ARM_REPEAT; 3.
DR   PROSITE; PS51214; IBB; 1.
PE   3: Inferred from homology;
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW   ECO:0000256|PIRNR:PIRNR005673};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009022};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005673}.
FT   DOMAIN          1..54
FT                   /note="IBB"
FT                   /evidence="ECO:0000259|PROSITE:PS51214"
FT   REPEAT          113..155
FT                   /note="ARM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT   REPEAT          155..183
FT                   /note="ARM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT   REPEAT          197..225
FT                   /note="ARM"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT   REGION          1..50
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   523 AA;  58008 MW;  A1DE55E6B3354820 CRC64;
     MSSDQHRWKN YKNKGLDQRE MRRRREEEGV QLRKVKRDQQ LSKRRQVSAM VDDDDTGMEM
     KSEISPKGKY DLESMMSNMY SADLDLVLEA TQKFRKLLSK EPHPPIQEVI NLGIVPKLVE
     LLKWQNDTLQ FEAAWALTNI ASGTSLQTAT VLQAGAVPVL IELLSSSNVD IQEQSVWALG
     NIAGDSTPCR DHVLGLNILP SLLQLIASAQ KLSLVRNAVW ALSNLCRGKN PLPDFGIVSI
     ALPTLARLLY ADDKEVLADT CWALSYLTDG PNDRIQKVIE VGVCKRLVEL LLHTHSSVQS
     AALRAVGNVV TGDDVQTQVI IECSALSNLS TLLDSSRDSI KKEACWTVSN ITAGNKTQIQ
     AVIDANIIPK LIHVASMSDY KTQKEITWAI TNATTGGNEQ QVRFIASQGA IRPLCEILGV
     MDAKIVDVAM TGLENILRVG ERIGKAENRP NPYAILVEEA GGIEKINFLQ RHDNQTLYKK
     AYNIIDKYFP SDEADGEITP SIDPANSQYS FGNFNEHHGN FDF
//