ID B3RYM7_TRIAD Unreviewed; 667 AA.
AC B3RYM7;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=G-protein coupled receptors family 3 profile domain-containing protein {ECO:0000259|PROSITE:PS50259};
GN ORFNames=TRIADDRAFT_56611 {ECO:0000313|EMBL:EDV25068.1};
OS Trichoplax adhaerens (Trichoplax reptans).
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV25068.1, ECO:0000313|Proteomes:UP000009022};
RN [1] {ECO:0000313|EMBL:EDV25068.1, ECO:0000313|Proteomes:UP000009022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV25068.1,
RC ECO:0000313|Proteomes:UP000009022};
RX PubMed=18719581; DOI=10.1038/nature07191;
RA Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA Rokhsar D.S.;
RT "The Trichoplax genome and the nature of placozoans.";
RL Nature 454:955-960(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; DS985245; EDV25068.1; -; Genomic_DNA.
DR RefSeq; XP_002112958.1; XM_002112922.1.
DR AlphaFoldDB; B3RYM7; -.
DR STRING; 10228.B3RYM7; -.
DR EnsemblMetazoa; TriadT56611; TriadP56611; TriadG56611.
DR GeneID; 6754171; -.
DR KEGG; tad:TRIADDRAFT_56611; -.
DR CTD; 6754171; -.
DR eggNOG; KOG1055; Eukaryota.
DR HOGENOM; CLU_005240_3_0_1; -.
DR InParanoid; B3RYM7; -.
DR OMA; YSERAYQ; -.
DR OrthoDB; 2970339at2759; -.
DR PhylomeDB; B3RYM7; -.
DR Proteomes; UP000009022; Unassembled WGS sequence.
DR GO; GO:0038039; C:G protein-coupled receptor heterodimeric complex; IBA:GO_Central.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IBA:GO_Central.
DR GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IBA:GO_Central.
DR CDD; cd15047; 7tmC_GABA-B-like; 1.
DR CDD; cd06366; PBP1_GABAb_receptor; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR002455; GPCR3_GABA-B.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR10519; GABA-B RECEPTOR; 1.
DR PANTHER; PTHR10519:SF20; GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR PRINTS; PR01177; GABAB1RECPTR.
DR PRINTS; PR01176; GABABRECEPTR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009022};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 422..445
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 457..476
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 496..515
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 536..557
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 427..600
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 667 AA; 75363 MW; 4308EF717DFD7EED CRC64;
MVPLSTRGPS GIDLIETVKL ALSDINSNDT ILSQYELKAE IGFSKFNPAS AIDVFIRMIM
QKTIKVGIIG AQNSRSSEYV ASAAKSWNLA QISHGSTSPI LSNREQFPYF FRTALSDISY
NLARVAFSLH YGWTKVAVLY QIATAYTAAA NDLVSDFKSK NITDVYAEGV LDQFAVVIGN
LKAKDMRIIY AIGQAPVILH VLCEAYKQKL YGPKYVWILV GWYPNDWWEV EMQPHTKCTP
DQIYQVIQNY FYVYRSYPQT STEPTISGRS PLNFNQQFQH LNNVTTTNTL RAYMYDAVWT
MAHALDKTEQ QLLPQNRSLS QFNYESSDIR STIVKNIADM SILGITGEIK FFGADRLGDV
YIFQFQGEKS QNKTVPVGLY KAATDSVTIF SENKVVWPNG FPPLSQSVIK IQTLHISLGL
TIIYLALSIL GILTSLLFFA FSLYYQNHKQ IKLLSPRMNA LFAIGCCICY VSVVMMAIDT
NFTTTIGFSI LCQANIWLLC LGFTLAFGSL FAKMWRVYRI FALKTAKRII VKDWHLLAVV
SQLAIVDIVL LTIWTVVDPL IADVITSTTT EPKHDIVFKQ TSYVCTCKNT AVWLGLINLW
RNPNHWGRRK IADQQEVFVD ESLRGVGLVS SDTTFTTIES GRCALQNVIE KYYTYHHSLE
VIILRVQ
//
