ID   B3RYS6_TRIAD            Unreviewed;       931 AA.
AC   B3RYS6;
DT   02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   02-SEP-2008, sequence version 1.
DT   27-MAR-2024, entry version 70.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EDV25093.1};
GN   ORFNames=TRIADDRAFT_25898 {ECO:0000313|EMBL:EDV25093.1};
OS   Trichoplax adhaerens (Trichoplax reptans).
OC   Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC   Trichoplax.
OX   NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV25093.1, ECO:0000313|Proteomes:UP000009022};
RN   [1] {ECO:0000313|EMBL:EDV25093.1, ECO:0000313|Proteomes:UP000009022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV25093.1,
RC   ECO:0000313|Proteomes:UP000009022};
RX   PubMed=18719581; DOI=10.1038/nature07191;
RA   Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA   Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA   Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA   Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA   Rokhsar D.S.;
RT   "The Trichoplax genome and the nature of placozoans.";
RL   Nature 454:955-960(2008).
CC   -!- SIMILARITY: Belongs to the RNR ribonuclease family.
CC       {ECO:0000256|ARBA:ARBA00005785, ECO:0000256|RuleBase:RU003901}.
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DR   EMBL; DS985245; EDV25093.1; -; Genomic_DNA.
DR   RefSeq; XP_002112983.1; XM_002112947.1.
DR   AlphaFoldDB; B3RYS6; -.
DR   STRING; 10228.B3RYS6; -.
DR   EnsemblMetazoa; TriadT25898; TriadP25898; TriadG25898.
DR   GeneID; 6754196; -.
DR   KEGG; tad:TRIADDRAFT_25898; -.
DR   CTD; 6754196; -.
DR   eggNOG; KOG2102; Eukaryota.
DR   HOGENOM; CLU_002333_5_0_1; -.
DR   InParanoid; B3RYS6; -.
DR   OMA; VKVHMDS; -.
DR   OrthoDB; 945235at2759; -.
DR   PhylomeDB; B3RYS6; -.
DR   Proteomes; UP000009022; Unassembled WGS sequence.
DR   GO; GO:0000177; C:cytoplasmic exosome (RNase complex); IBA:GO_Central.
DR   GO; GO:0000176; C:nuclear exosome (RNase complex); IBA:GO_Central.
DR   GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IBA:GO_Central.
DR   GO; GO:0004519; F:endonuclease activity; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0016075; P:rRNA catabolic process; IBA:GO_Central.
DR   CDD; cd09862; PIN_Rrp44-like; 1.
DR   Gene3D; 2.40.50.690; -; 1.
DR   Gene3D; 2.40.50.700; -; 1.
DR   Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR   InterPro; IPR041505; Dis3_CSD2.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   InterPro; IPR002716; PIN_dom.
DR   InterPro; IPR001900; RNase_II/R.
DR   InterPro; IPR022966; RNase_II/R_CS.
DR   InterPro; IPR033771; Rrp44_CSD1.
DR   InterPro; IPR033770; RRP44_S1.
DR   PANTHER; PTHR23355:SF35; EXOSOME COMPLEX EXONUCLEASE RRP44; 1.
DR   PANTHER; PTHR23355; RIBONUCLEASE; 1.
DR   Pfam; PF17849; OB_Dis3; 1.
DR   Pfam; PF13638; PIN_4; 1.
DR   Pfam; PF00773; RNB; 1.
DR   Pfam; PF17216; Rrp44_CSD1; 1.
DR   Pfam; PF17215; Rrp44_S1; 1.
DR   SMART; SM00670; PINc; 1.
DR   SMART; SM00955; RNB; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 3.
DR   SUPFAM; SSF88723; PIN domain-like; 1.
DR   PROSITE; PS01175; RIBONUCLEASE_II; 1.
PE   3: Inferred from homology;
KW   Exosome {ECO:0000256|ARBA:ARBA00022835};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022722};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009022};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT   DOMAIN          62..178
FT                   /note="PIN"
FT                   /evidence="ECO:0000259|SMART:SM00670"
FT   DOMAIN          460..792
FT                   /note="Ribonuclease II/R"
FT                   /evidence="ECO:0000259|SMART:SM00955"
SQ   SEQUENCE   931 AA;  106397 MW;  86447681C73A2514 CRC64;
     MLKSRTFVKK TRKGGVVKVV QEHYLRDDVW CGVIGCSSCN TTQAVLDPQC LNVQSNLCPK
     SHFIIPDTNV VCKQIDILEE NCIKHAIFLQ TVLQEVKHLS ASTYRRIRDA IANPEKKFYV
     FSNEHHKKTY IERGKDESPN DRNDRAIRVA AKWYQKHMQD NCFQTDIVLL TNDVENKEKA
     VQDNLTTYTM YEYVMALTDS PELMDKLSGD FEDDEKNQIV FAEYLPLSKI QSAIKAGRLI
     QGTFQSSRDN YKEGFVRVHG EEQDIFIKDL DSINRAIQDD VVAVEMLPKQ EWTKPSGLVC
     RDVENNENDN AETAGLENTA REEKLENYIA DALPSGKVVG IIKRNWRPYC GILLPNPNPN
     ARRFLFRAAD RRIPRIRILT RQSSNLLGQR IIVSVDAWQR KRRYPEGHFV RRLGPIGDKE
     TESEVLLIEH NVPYQQFSQA VLNDLPTLPW EITDDDAKQR EDLRHLTICS IDPPGCTDID
     DALHLTALEN GNYEVGVHIA DVSHFIRPGT AIDIEAANRG TTVYLAEKRI DMVPELLSSN
     LCSLRSNVDR FAFSCIWELS PDADVIAARF TKSIIKSQAA FTYAEAQLII DDKQRNDDIA
     ISLRSLNVLA QALNKKRLDQ GALSLASPEI RFQVDSETHD PLELVKKELR ETNSLVEEFM
     LLANITVAER IYEIFPQCAL LRRHPSPPLS NFDILLKSAA VKNIQLQVDS AKMLSTSLAQ
     ADLQDNPYFN TLLRILVTRC MMQAVYFCSG TLAYQDYCHY GLATPIYTHF TSPIRRYSDI
     IVHRLLAISI GADKTYPDLM KKDKVQELCN HLNFRHKMAQ YAQRSSVSLY AQLFFRNRVT
     KEEGYILFVR KNAIQVLIPK YGIENTIFLR SADGSELPFI HDEQNLSLTY QDITLQVFDR
     VLVEIAVEHN EIQGSKIRLQ LLEPQVCSFS V
//