ID B3RZ84_TRIAD Unreviewed; 683 AA.
AC B3RZ84;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=G-protein coupled receptors family 2 profile 2 domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=TRIADDRAFT_57362 {ECO:0000313|EMBL:EDV23799.1};
OS Trichoplax adhaerens (Trichoplax reptans).
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV23799.1, ECO:0000313|Proteomes:UP000009022};
RN [1] {ECO:0000313|EMBL:EDV23799.1, ECO:0000313|Proteomes:UP000009022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV23799.1,
RC ECO:0000313|Proteomes:UP000009022};
RX PubMed=18719581; DOI=10.1038/nature07191;
RA Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA Rokhsar D.S.;
RT "The Trichoplax genome and the nature of placozoans.";
RL Nature 454:955-960(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; DS985246; EDV23799.1; -; Genomic_DNA.
DR RefSeq; XP_002113325.1; XM_002113289.1.
DR AlphaFoldDB; B3RZ84; -.
DR STRING; 10228.B3RZ84; -.
DR EnsemblMetazoa; TriadT57362; TriadP57362; TriadG57362.
DR GeneID; 6754538; -.
DR KEGG; tad:TRIADDRAFT_57362; -.
DR CTD; 6754538; -.
DR eggNOG; KOG4193; Eukaryota.
DR HOGENOM; CLU_402993_0_0_1; -.
DR InParanoid; B3RZ84; -.
DR OMA; RTWENIA; -.
DR OrthoDB; 1114672at2759; -.
DR PhylomeDB; B3RZ84; -.
DR Proteomes; UP000009022; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15933; 7tmB2_GPR133-like_Adhesion_V; 1.
DR CDD; cd00037; CLECT; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF437; GPS DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009022};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 359..383
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 395..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 429..451
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 463..484
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 504..530
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 551..573
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 579..602
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 6..69
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 360..603
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 625..650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 683 AA; 77446 MW; DB4F22E2F7643AE9 CRC64;
MQYHGLWIGL RSQHSFNNIS NYAYKWIDGS NTSLFHNWLT TPLVGSISTE LCVATLRPLG
WKWFQYNCNT TFLDGFICEK FAIPVKISPE KHLQYVSNTI RNQIYANETS DKSIGQLEAA
SQLLSRTWEN IAISRKNDTL KFIVLNESIE ITQVLFNKAE TLIRAGWKNA LDPILATMKN
LEKLTVRVAG TPLRNPIVIQ TTRMELRMEK IDTPYSTYIG LQTTTNNWLQ LHYDTNLVNK
SNVVVIIYKN YRLFSELPSE SSLDVNTNIV SCSLVSTINS SKIQPTEFQY LLSNYKERVA
LSDIQCSYWN FNQSNWSTSG CNFVRQYYGR THCRCNHLTH FAALMIVTNT TVNQYHSKIL
GTIGIAGVVT SAVFLLFTLI ILVSLRNLRS DRFFIHKNLC LALLLANVSA VITSQAYLHH
TACKVSAIIQ HFLFTAAFTW MLVEGLHLYL LMVKVFTSGR SKTFLYVFVG WGIPVIIVAT
SIAIRFNDYG SNRICWLSIK NGLIWAFVGP VIAIITINFV IFILVARIIC RSSSPVAIEQ
KTADFATIKS TLRGAVILVP ILGLTWIFGV LTINEQTLFF DYIFVITNSL QGFFIFLFHC
ALNSEVQNAL KNRIGQYDAV KQLNNSPQNN SNGKQGKNTG NNVESWNGHH SSTLNKFKSE
FYQNNTGNHD DLVVVRKSFE SKS
//
