ID   B3S023_TRIAD            Unreviewed;      1359 AA.
AC   B3S023;
DT   02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   02-SEP-2008, sequence version 1.
DT   08-NOV-2023, entry version 63.
DE   RecName: Full=PH domain-containing protein {ECO:0000259|PROSITE:PS50003};
GN   ORFNames=TRIADDRAFT_57658 {ECO:0000313|EMBL:EDV23931.1};
OS   Trichoplax adhaerens (Trichoplax reptans).
OC   Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC   Trichoplax.
OX   NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV23931.1, ECO:0000313|Proteomes:UP000009022};
RN   [1] {ECO:0000313|EMBL:EDV23931.1, ECO:0000313|Proteomes:UP000009022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV23931.1,
RC   ECO:0000313|Proteomes:UP000009022};
RX   PubMed=18719581; DOI=10.1038/nature07191;
RA   Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA   Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA   Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA   Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA   Rokhsar D.S.;
RT   "The Trichoplax genome and the nature of placozoans.";
RL   Nature 454:955-960(2008).
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DR   EMBL; DS985246; EDV23931.1; -; Genomic_DNA.
DR   RefSeq; XP_002113457.1; XM_002113421.1.
DR   EnsemblMetazoa; TriadT57658; TriadP57658; TriadG57658.
DR   GeneID; 6755053; -.
DR   KEGG; tad:TRIADDRAFT_57658; -.
DR   CTD; 6755053; -.
DR   HOGENOM; CLU_257137_0_0_1; -.
DR   InParanoid; B3S023; -.
DR   OrthoDB; 2968233at2759; -.
DR   Proteomes; UP000009022; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0030036; P:actin cytoskeleton organization; IBA:GO_Central.
DR   CDD; cd00821; PH; 3.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR037370; Pleckstrin.
DR   PANTHER; PTHR12092:SF16; PH DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR12092; PLECKSTRIN; 1.
DR   Pfam; PF00169; PH; 2.
DR   SMART; SM00233; PH; 3.
DR   SUPFAM; SSF50729; PH domain-like; 3.
DR   PROSITE; PS50003; PH_DOMAIN; 2.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000009022}.
FT   DOMAIN          545..638
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          1071..1174
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          114..173
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          644..683
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          843..890
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          980..1023
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1040..1069
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1331..1359
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        139..154
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        155..173
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        644..665
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        983..1023
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1342..1359
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1359 AA;  154637 MW;  60427A2A09A46714 CRC64;
     MSRKRHSAHG KILINEKLSA RAEQLRLDLL RLATDLQQVA QASELSRSSR WNSTRGRWSA
     AGQKDAQDFV SVQRQIARGE VARQHAHYKT MPCRIRKPRP QLFQSWLKGD QVEEQEDDSV
     FDQHDSNQDQ SAIAANPEEN EKLNEERYLE VVESDSEKNG TNSPKPQTNT QESIQFKQVN
     DVVAINIDDV VRVATFIGQI CEYRVDGIKE NKLRWCVITK EMDLYLYDTF NQPYVKKMKL
     PGYKLHLISQ YMGSYQHFII KLNHQDRVPK TISFVMDMSV DLVDDENPPS KFQLLQRQKR
     NHHATVRKRN VAIASGVKQP RAKSVESSYD DDTYVYDDIF AQLRKLRMSI FHSSLPINQD
     FENMLTQISE QEQIRVDEEK SKAMRPRSER TSQDPINTTL RTTIENGGTV RSKSANSLRL
     PKPIDRTMSN TTSVSTTDDY YDRSDNISRY EISSGASSDV YLQPKLKPAL IYEDDKYEVP
     VLSELGATDT SVRKEMPILP KLRKPPSPPS FRPRNRIRRF ISDSFSDKFD TRDRNTERFE
     KLAKKSLVSG YLLRSGGANI QRKRWCILTK DRLYFFVKER DYLPRSIMKL KDCHLDESQL
     AEKAIITLIF RKSKRIKLTC TNLNEYNTWL SALKSALEEF RATSSDSESN GSKTPKIVND
     TSDTSDSDNT DVEDSHATTT SSDNTINVSR SITSVSTKSG IVIVDSDPSS GGSVLSFNYQ
     QPSFFRNAFQ GKLDRCIFEN NKYVWQNRWC EINRSILYCY VRERDSIACE FQVSLYQCRV
     EPVNLADKGR PYAFKLISSD NQELATFAHD NREALQSVIR LIRHAAEMSS PVDINEYAKA
     DSDLERNAKT TSAKTKNVKK PKLPMALFQQ RPLPPPASNL GRSKSSQDIS SEDGFYERNL
     QTAQGSIDTE VVYHTPTSAT SKGFSEEIYE DIDKAKNVIL DMYEEASIAT SGVSTINKDK
     NIEDLYEKVD DLRERLRKKS VQVKPITETS SSSNASKSVT PRHQSSDSAK NIPTDSDSDI
     GATSPLFNSA NYASLNKLKN MNRTDSGSSS QKSLEAPFPS RTRSSFSDGE MTVIEGELNL
     PKQSTMNLTF KKRWCVVKAS DSRSRLLIFR RKGDRKPTDE YILSKLQLLV DSKLPNEFKL
     KYISGENAGS SLHFQAFGRE EAAAWAEKLL KHTIIATQSD ASIVASFIAE NSANSGVNTP
     TNFSRTRSKR FFTAIFDNKG RSSSFTDVHS EKKMGKAIQK RLTATIERDE KVSMSINQLM
     QRESQLQAQV EKITSDLKRT KLDLRNAQDT QVKASSTEAK LASKTCEKLF KKMQSLEQSL
     EKTIQDLNKT QSDIKRLQSR RSFGDMQISQ SSPKTKPRK
//