ID B3S050_TRIAD Unreviewed; 181 AA.
AC B3S050;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=60S ribosome subunit biogenesis protein NIP7 homolog {ECO:0000256|ARBA:ARBA00018162, ECO:0000256|PIRNR:PIRNR017190};
GN ORFNames=TRIADDRAFT_50432 {ECO:0000313|EMBL:EDV24330.1};
OS Trichoplax adhaerens (Trichoplax reptans).
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV24330.1, ECO:0000313|Proteomes:UP000009022};
RN [1] {ECO:0000313|EMBL:EDV24330.1, ECO:0000313|Proteomes:UP000009022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV24330.1,
RC ECO:0000313|Proteomes:UP000009022};
RX PubMed=18719581; DOI=10.1038/nature07191;
RA Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA Rokhsar D.S.;
RT "The Trichoplax genome and the nature of placozoans.";
RL Nature 454:955-960(2008).
CC -!- FUNCTION: Required for proper 34S pre-rRNA processing and 60S ribosome
CC subunit assembly. {ECO:0000256|ARBA:ARBA00004087,
CC ECO:0000256|PIRNR:PIRNR017190}.
CC -!- SUBUNIT: Interacts with pre-ribosome complex.
CC {ECO:0000256|PIRNR:PIRNR017190}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}.
CC -!- SIMILARITY: Belongs to the NIP7 family. {ECO:0000256|ARBA:ARBA00009895,
CC ECO:0000256|PIRNR:PIRNR017190}.
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DR EMBL; DS985246; EDV24330.1; -; Genomic_DNA.
DR RefSeq; XP_002113856.1; XM_002113820.1.
DR AlphaFoldDB; B3S050; -.
DR STRING; 10228.B3S050; -.
DR EnsemblMetazoa; TriadT50432; TriadP50432; TriadG50432.
DR GeneID; 6755068; -.
DR KEGG; tad:TRIADDRAFT_50432; -.
DR CTD; 6755068; -.
DR eggNOG; KOG3492; Eukaryota.
DR HOGENOM; CLU_097217_0_0_1; -.
DR InParanoid; B3S050; -.
DR OMA; VVYNMND; -.
DR OrthoDB; 177185at2759; -.
DR PhylomeDB; B3S050; -.
DR Proteomes; UP000009022; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR GO; GO:0042255; P:ribosome assembly; IEA:InterPro.
DR CDD; cd21146; Nip7_N_euk; 1.
DR CDD; cd21151; PUA_Nip7-like; 1.
DR Gene3D; 3.10.450.220; -; 1.
DR Gene3D; 2.30.130.10; PUA domain; 1.
DR InterPro; IPR040598; NIP7_N.
DR InterPro; IPR002478; PUA.
DR InterPro; IPR015947; PUA-like_sf.
DR InterPro; IPR036974; PUA_sf.
DR InterPro; IPR016686; Ribosomal_synth_fac_NIP7.
DR InterPro; IPR005155; UPF0113_PUA.
DR PANTHER; PTHR23415:SF4; 60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7 HOMOLOG; 1.
DR PANTHER; PTHR23415; CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7; 1.
DR Pfam; PF03657; UPF0113; 1.
DR Pfam; PF17833; UPF0113_N; 1.
DR PIRSF; PIRSF017190; Rbsml_synth_fac_NIP7; 1.
DR SMART; SM00359; PUA; 1.
DR SUPFAM; SSF88802; Pre-PUA domain; 1.
DR SUPFAM; SSF88697; PUA domain-like; 1.
DR PROSITE; PS50890; PUA; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR017190};
KW Reference proteome {ECO:0000313|Proteomes:UP000009022};
KW Ribosome biogenesis {ECO:0000256|ARBA:ARBA00022517,
KW ECO:0000256|PIRNR:PIRNR017190};
KW RNA-binding {ECO:0000256|PIRNR:PIRNR017190}.
FT DOMAIN 96..171
FT /note="PUA"
FT /evidence="ECO:0000259|SMART:SM00359"
SQ SEQUENCE 181 AA; 20681 MW; DACCB288C488FD7B CRC64;
MRPLTAEETK TFFEKLAKYI SPENIKLLLD RPDASYCFRL HKDRVFYASE KIMLTANNFA
RKELVSFGTC FGKFTKTGKF RLYMTALDYL APYAQFKVWV KPNGEQSFLY GNHVLKSHLG
RITDSTSKYQ GVIVMSMSDV PLGFGVSAKS TQECRRADPS SIVTFHQADV GEYLRTEETL
L
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