ID   B3S1K7_TRIAD            Unreviewed;      1023 AA.
AC   B3S1K7;
DT   02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   02-SEP-2008, sequence version 1.
DT   27-MAR-2024, entry version 78.
DE   RecName: Full=HECT domain-containing protein {ECO:0000259|PROSITE:PS50237};
GN   ORFNames=TRIADDRAFT_28070 {ECO:0000313|EMBL:EDV23245.1};
OS   Trichoplax adhaerens (Trichoplax reptans).
OC   Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC   Trichoplax.
OX   NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV23245.1, ECO:0000313|Proteomes:UP000009022};
RN   [1] {ECO:0000313|EMBL:EDV23245.1, ECO:0000313|Proteomes:UP000009022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV23245.1,
RC   ECO:0000313|Proteomes:UP000009022};
RX   PubMed=18719581; DOI=10.1038/nature07191;
RA   Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA   Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA   Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA   Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA   Rokhsar D.S.;
RT   "The Trichoplax genome and the nature of placozoans.";
RL   Nature 454:955-960(2008).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DS985247; EDV23245.1; -; Genomic_DNA.
DR   RefSeq; XP_002114155.1; XM_002114119.1.
DR   AlphaFoldDB; B3S1K7; -.
DR   STRING; 10228.B3S1K7; -.
DR   EnsemblMetazoa; TriadT28070; TriadP28070; TriadG28070.
DR   GeneID; 6755368; -.
DR   KEGG; tad:TRIADDRAFT_28070; -.
DR   CTD; 6755368; -.
DR   eggNOG; KOG4427; Eukaryota.
DR   HOGENOM; CLU_002173_2_0_1; -.
DR   InParanoid; B3S1K7; -.
DR   OMA; PNHWLIP; -.
DR   OrthoDB; 1386at2759; -.
DR   PhylomeDB; B3S1K7; -.
DR   Proteomes; UP000009022; Unassembled WGS sequence.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR   GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   CDD; cd00078; HECTc; 1.
DR   Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR   InterPro; IPR044611; E3A/B/C-like.
DR   InterPro; IPR000569; HECT_dom.
DR   InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR   PANTHER; PTHR45700:SF3; UBIQUITIN-PROTEIN LIGASE E3B; 1.
DR   PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR   Pfam; PF00632; HECT; 1.
DR   SMART; SM00119; HECTc; 1.
DR   SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR   PROSITE; PS50237; HECT; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000009022};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW   ECO:0000256|PROSITE-ProRule:PRU00104}.
FT   DOMAIN          655..1023
FT                   /note="HECT"
FT                   /evidence="ECO:0000259|PROSITE:PS50237"
FT   ACT_SITE        991
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ   SEQUENCE   1023 AA;  117825 MW;  D34D8360D08823AC CRC64;
     MYRHLLNVVY SVKTLTIFCE IHELAIEIFN KMRWLLFIFQ DDVDSKRLEM LCHRILSNMT
     VSDSPKLWYV TLAISNQYLP LWLYQAKKLL QVCSEQLANM KINKKNELEA MQLYLTVLVT
     FSSTKSWKLM SSKANKNFRP ILDQICKQVL LHLVNNNFFA NMKNFLWNCT RSGELKLSKV
     TLSGVIVLIQ RTFSASSNNL KLLKQFMESI MAFPALLYHV KKLSPEASLS LAEFRQSHVL
     EVVLETYADG SNLSNLTTKL GGYYTFSLLG NLIQLSHYAD KVSNLENNVR RNKSIIMYLL
     NYCHDQNSVK NSNATVHHPL FGWCSEALAT DLQDSVPLIG KQFQYLWMPS AVQLFFTDIF
     EKSDETPNEA AASVKTGDSV KKKKGLFGRV FSKSQIKGFI LSSTKVKTNS DLIKRICSTC
     AMYNTAISTL PEMRTDVLTG ISYYYGLLEP LWKFIHTLYM EEGPKIFHEN SPNLSDTISL
     TTLFCNCCCH LITIVDDIEL YQENKPFTLD ELIKMVTLLN HMVFYAIWKL DGAKYPYEYR
     QMINAGHMLL MVLYDRDCRR SFTPENHWII KELNFNEFIS ALNEGTNRSH VLLRKIAHVI
     PREKRVDLFR KLVADDKKSL GIFADTLAIR PNYTYININR SRLLEDGYEQ LTQLPPEAIK
     RTIKVQFVNE QGLTEAGIDE SGVFKEFLEE TIKKAFDPAL NLFKVTCGDE PRLYPSPTSY
     IHGNHLPLFE FVGRMLGKAV YEGLVVEVPL ALFFLNNVLG GQHSILYSCI DELPSLDPEL
     YKNLNYVKNY EDDVEDLALT FSFDEDVLGK IITHDLKYGG STIPVTNENK LSYIHLMAHF
     RLRKQLKKQT AAFIRGFHSV IKPEWLQVFS GPELQLLIAG ENTTISILDL KKYTKYLGGY
     HSKHRVIQWL WDILKNDFGE EDRCKFLKFV TSCSKPPLQG FSNLQPPFTI RYVEAENEED
     RESISRVLFR ALSIPNRKSQ STSRLPTSST CFNLLKLPNY HSKHVLREKL RYAIQSNSGF
     ELS
//