ID B3S2B3_TRIAD Unreviewed; 527 AA.
AC B3S2B3;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=DNA polymerase epsilon subunit {ECO:0000256|PIRNR:PIRNR000799};
DE AltName: Full=DNA polymerase II subunit 2 {ECO:0000256|PIRNR:PIRNR000799};
GN ORFNames=TRIADDRAFT_27613 {ECO:0000313|EMBL:EDV23300.1};
OS Trichoplax adhaerens (Trichoplax reptans).
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV23300.1, ECO:0000313|Proteomes:UP000009022};
RN [1] {ECO:0000313|EMBL:EDV23300.1, ECO:0000313|Proteomes:UP000009022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV23300.1,
RC ECO:0000313|Proteomes:UP000009022};
RX PubMed=18719581; DOI=10.1038/nature07191;
RA Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA Rokhsar D.S.;
RT "The Trichoplax genome and the nature of placozoans.";
RL Nature 454:955-960(2008).
CC -!- FUNCTION: Participates in DNA repair and in chromosomal DNA
CC replication. {ECO:0000256|PIRNR:PIRNR000799}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR000799}.
CC -!- SIMILARITY: Belongs to the DNA polymerase epsilon subunit B family.
CC {ECO:0000256|ARBA:ARBA00009560, ECO:0000256|PIRNR:PIRNR000799}.
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DR EMBL; DS985247; EDV23300.1; -; Genomic_DNA.
DR RefSeq; XP_002114210.1; XM_002114174.1.
DR AlphaFoldDB; B3S2B3; -.
DR STRING; 10228.B3S2B3; -.
DR EnsemblMetazoa; TriadT27613; TriadP27613; TriadG27613.
DR GeneID; 6755741; -.
DR KEGG; tad:TRIADDRAFT_27613; -.
DR CTD; 6755741; -.
DR eggNOG; KOG3818; Eukaryota.
DR HOGENOM; CLU_010628_2_0_1; -.
DR InParanoid; B3S2B3; -.
DR OMA; FFCEGCF; -.
DR OrthoDB; 166885at2759; -.
DR PhylomeDB; B3S2B3; -.
DR Proteomes; UP000009022; Unassembled WGS sequence.
DR GO; GO:0008622; C:epsilon DNA polymerase complex; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006261; P:DNA-templated DNA replication; IBA:GO_Central.
DR GO; GO:0042276; P:error-prone translesion synthesis; IBA:GO_Central.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.60.21.60; -; 1.
DR InterPro; IPR007185; DNA_pol_a/d/e_bsu.
DR InterPro; IPR024639; DNA_pol_e_bsu_N.
DR InterPro; IPR016266; POLE2.
DR PANTHER; PTHR12708:SF0; DNA POLYMERASE EPSILON SUBUNIT 2; 1.
DR PANTHER; PTHR12708; DNA POLYMERASE EPSILON SUBUNIT B; 1.
DR Pfam; PF04042; DNA_pol_E_B; 1.
DR Pfam; PF12213; Dpoe2NT; 1.
DR PIRSF; PIRSF000799; DNA_pol_eps_2; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|PIRNR:PIRNR000799};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR000799};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR000799};
KW Reference proteome {ECO:0000313|Proteomes:UP000009022}.
FT DOMAIN 9..76
FT /note="DNA polymerase epsilon subunit B N-terminal"
FT /evidence="ECO:0000259|Pfam:PF12213"
FT DOMAIN 289..488
FT /note="DNA polymerase alpha/delta/epsilon subunit B"
FT /evidence="ECO:0000259|Pfam:PF04042"
SQ SEQUENCE 527 AA; 60116 MW; 3EB7C5705993751A CRC64;
MATNYNGIII KSFKLHGLLL SSEACRYLNE NLPISHGSNK EKLNENLQLI IDALQRQPSS
STIIDKGRVE SAIQECQQNS HDEQSKIFNV INIFKTPKYY YNTEKKKFLR GNDDTNTFGL
AKDKAAYFRE RYNLIYQRTI RHDLFCPSST GNKNIDKYRQ QQQFELKSIE YLLSTSRIED
KIVVLGMITR HREGGFALED ITGIVKLDIS KTLFHAGLFT EACFVLAEGV YEDDVFRASA
IGFPPAEPAK SFYRHFGDIN LFGGPFTRSF KFSINLKAVE EHNSGTMLIF LSDVWLDQSS
VLDKLRTLFA GYSNAPPMAF ILIGNYLSTP YGYKESKIMK ECLQTLADLI CEFPNIKERS
HFVFVPSIHD VGFGNILPRP PLPESVTADI RERLPWVDFA SNPCRIQYCT QDIVIFREDM
IGKVCRNCIH IPEDGEDIPS HFVRTITSQG TLCPLPLNVS PVYWNYSYAL SLYPSPDLVV
LANNYEPFEI SRIGSLFINP GSFSRNDFSF QVYLPSSREA EKRSVLK
//
