ID B3S2C0_TRIAD Unreviewed; 498 AA.
AC B3S2C0;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Choline/carnitine acyltransferase domain-containing protein {ECO:0000259|Pfam:PF00755};
GN ORFNames=TRIADDRAFT_50581 {ECO:0000313|EMBL:EDV23304.1};
OS Trichoplax adhaerens (Trichoplax reptans).
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV23304.1, ECO:0000313|Proteomes:UP000009022};
RN [1] {ECO:0000313|EMBL:EDV23304.1, ECO:0000313|Proteomes:UP000009022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV23304.1,
RC ECO:0000313|Proteomes:UP000009022};
RX PubMed=18719581; DOI=10.1038/nature07191;
RA Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA Rokhsar D.S.;
RT "The Trichoplax genome and the nature of placozoans.";
RL Nature 454:955-960(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(R)-carnitine + 4,8-dimethylnonanoyl-CoA = CoA + O-4,8-
CC dimethylnonanoyl-(R)-carnitine; Xref=Rhea:RHEA:44860,
CC ChEBI:CHEBI:16347, ChEBI:CHEBI:57287, ChEBI:CHEBI:77061,
CC ChEBI:CHEBI:84654; Evidence={ECO:0000256|ARBA:ARBA00024283};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005232}.
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DR EMBL; DS985247; EDV23304.1; -; Genomic_DNA.
DR RefSeq; XP_002114214.1; XM_002114178.1.
DR AlphaFoldDB; B3S2C0; -.
DR STRING; 10228.B3S2C0; -.
DR EnsemblMetazoa; TriadT50581; TriadP50581; TriadG50581.
DR GeneID; 6755744; -.
DR KEGG; tad:TRIADDRAFT_50581; -.
DR CTD; 6755744; -.
DR eggNOG; KOG3719; Eukaryota.
DR HOGENOM; CLU_013513_4_2_1; -.
DR InParanoid; B3S2C0; -.
DR OMA; NRWWDKS; -.
DR OrthoDB; 1429709at2759; -.
DR PhylomeDB; B3S2C0; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000009022; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0004095; F:carnitine O-palmitoyltransferase activity; IBA:GO_Central.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IBA:GO_Central.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 1.10.275.20; Choline/Carnitine o-acyltransferase; 1.
DR Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR InterPro; IPR000542; Carn_acyl_trans.
DR InterPro; IPR042572; Carn_acyl_trans_N.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR039551; Cho/carn_acyl_trans.
DR InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR22589:SF16; CARNITINE O-PALMITOYLTRANSFERASE 2, MITOCHONDRIAL; 1.
DR Pfam; PF00755; Carn_acyltransf; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000009022};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 100..483
FT /note="Choline/carnitine acyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00755"
FT ACT_SITE 263
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ SEQUENCE 498 AA; 56302 MW; D015FEB1B3A27674 CRC64;
MHYQPSLPRL PIPSLEKTCM RYLNGVQPLL SAKEFEQTSR IVKDFEENEG KALHKELVEN
DKKNKHTSYI AKPWMDMYLS DRTAIPINYN PGLIFLNKNP QITDQYKNLF KSTRIPKLNM
DYNQAFPDSN HILVMKNGRF YTFNVIDPID GSPLPPAYIY AQLRNIAESE SSPPEFPINF
LTTENRDTWA NLREELEADE LNAESLKAID SAILALCLDD VGHDDPAKAM LQVLHGNGYN
RWFDKSFQII VNKKGEGAMN FEHAWGDGVA VMRYVIDMID DSSKNLITKE SVSSNVDIES
QTKELQFNLS ENLKSSINVA KENFVALSNT LESQVVQYEK MNKNYIKEKR LSPDSLAYYR
MTGQIPTVYE SCSTAAFKHG RTECLRSVSM LTKACCEAFG RNNPATASEI RELMGKCQGF
DRHLFALRVL AASSLNKLPD IFLDPTFSKA SHFTLSTSTL GTEYITNGGF GPVVKDGLGL
PYMGDSLIEL CVIFLPRR
//
