ID B3S462_TRIAD Unreviewed; 831 AA.
AC B3S462;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=G-protein coupled receptors family 3 profile domain-containing protein {ECO:0000259|PROSITE:PS50259};
DE Flags: Fragment;
GN ORFNames=TRIADDRAFT_816 {ECO:0000313|EMBL:EDV22589.1};
OS Trichoplax adhaerens (Trichoplax reptans).
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV22589.1, ECO:0000313|Proteomes:UP000009022};
RN [1] {ECO:0000313|EMBL:EDV22589.1, ECO:0000313|Proteomes:UP000009022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV22589.1,
RC ECO:0000313|Proteomes:UP000009022};
RX PubMed=18719581; DOI=10.1038/nature07191;
RA Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA Rokhsar D.S.;
RT "The Trichoplax genome and the nature of placozoans.";
RL Nature 454:955-960(2008).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; DS985249; EDV22589.1; -; Genomic_DNA.
DR RefSeq; XP_002115133.1; XM_002115097.1.
DR AlphaFoldDB; B3S462; -.
DR EnsemblMetazoa; TriadT816; TriadP816; TriadG816.
DR GeneID; 6756157; -.
DR KEGG; tad:TRIADDRAFT_816; -.
DR CTD; 6756157; -.
DR eggNOG; KOG1056; Eukaryota.
DR HOGENOM; CLU_005389_1_1_1; -.
DR InParanoid; B3S462; -.
DR OMA; TWEINET; -.
DR OrthoDB; 1011589at2759; -.
DR PhylomeDB; B3S462; -.
DR Proteomes; UP000009022; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001640; F:adenylate cyclase inhibiting G protein-coupled glutamate receptor activity; IBA:GO_Central.
DR GO; GO:0007216; P:G protein-coupled glutamate receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0051966; P:regulation of synaptic transmission, glutamatergic; IBA:GO_Central.
DR CDD; cd13953; 7tm_classC_mGluR-like; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060:SF162; G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009022};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 570..593
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 605..625
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 637..661
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 682..708
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 728..749
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 761..783
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 795..820
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 570..831
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EDV22589.1"
FT NON_TER 831
FT /evidence="ECO:0000313|EMBL:EDV22589.1"
SQ SEQUENCE 831 AA; 94522 MW; B003AF83A12AC9D6 CRC64;
VKPGQFLIAG LFDVHDNYHP ITRKLQSINP RSLQRVQSMI YAIDAINNNS NLLPNITLGL
YLFDSGGSSQ LALTHAIDMI RNDLQKPKAN EKMCNCINTA ADCNAITNLT DIHMIQQTFN
KKIIGVIGPR SSKESIITAT LFTTYKMPQI SYASTSRTLS DKSRFGSFFR TVPSDTYQAQ
AIVDIVKYFG WDYIAVVSTN DQYGNQLRAK IVTLASEYQI CIAINAQFPS QFHDQIISDI
VNRLVNNVKV KTIILICSEA EAKVLLKEAQ YQNLTGRMWL GSDAWGNSPV IARTYSDVVI
GMIGVTLLQS KQKLNKYHEY LKTLNLCNNN INPWFNEYWY QFMSDNVTDY LKCGQMKNLS
NNYSIEFYSK SSLAAYVMDG VYAFAYALHK VLKCNNIFCH SRIIRQEDSL LWRDVTQNLK
RVHFNGYTTT QFKFDHMGNS RPKYDIFQLQ LTKDSDSNKA ESSKHLYFKK IGTWEINETT
NSSWFMISEN NLSRDHVVSS RCSNDCQPGT RQYITTSKCC WQCLPCLKHQ ISSKINADTC
TSCKRGSKPN NNQTDCVEIS PTESKLIDPI PLVVLITTAV SFLLTITTWL IIFKNRSTPI
VKASNIALTY TLLFFIGLCH VSPVMFILPK ALVGCHYIFP VILLPPANLN IVIINKIRII
VKLFKDKSFS RQVNFWNRDI GQFILIIGEI IIINSLILVI TALDPVIIER YVTEDNLVYF
RCKTRYELGA YLSMAILLII TTISAYLTYR ARHIPARFHE AKYVSLASLL ICFFTCIYIP
TIIFAHGPVQ STIGAFGMIG LIIGILLCLF TNKIYVILFV PQVNNRQRTI M
//
