UniProt: B3S5U0

Database: UniProt
Entry: B3S5U0_TRIAD

LinkDB:  B3S5U0_TRIAD 
Original site:  B3S5U0_TRIAD

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Ontology (1)   
   GO (1)   
Gene (2)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (13)   
   InterPro (5)   
   Pfam (2)   
   PROSITE (4)   
   SMART (2)   
Literature (1)   
   PubMed (1)   
All databases (19)   

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ID   B3S5U0_TRIAD            Unreviewed;      4197 AA.
AC   B3S5U0;
DT   02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   02-SEP-2008, sequence version 1.
DT   27-MAR-2024, entry version 68.
DE   RecName: Full=MAM domain-containing protein {ECO:0000259|PROSITE:PS50060};
GN   ORFNames=TRIADDRAFT_64188 {ECO:0000313|EMBL:EDV21958.1};
OS   Trichoplax adhaerens (Trichoplax reptans).
OC   Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC   Trichoplax.
OX   NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV21958.1, ECO:0000313|Proteomes:UP000009022};
RN   [1] {ECO:0000313|EMBL:EDV21958.1, ECO:0000313|Proteomes:UP000009022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV21958.1,
RC   ECO:0000313|Proteomes:UP000009022};
RX   PubMed=18719581; DOI=10.1038/nature07191;
RA   Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA   Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA   Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA   Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA   Rokhsar D.S.;
RT   "The Trichoplax genome and the nature of placozoans.";
RL   Nature 454:955-960(2008).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR   EMBL; DS985251; EDV21958.1; -; Genomic_DNA.
DR   RefSeq; XP_002115595.1; XM_002115559.1.
DR   SMR; B3S5U0; -.
DR   STRING; 10228.B3S5U0; -.
DR   EnsemblMetazoa; TriadT64188; TriadP64188; TriadG64188.
DR   GeneID; 6756806; -.
DR   KEGG; tad:TRIADDRAFT_64188; -.
DR   CTD; 6756806; -.
DR   eggNOG; KOG1095; Eukaryota.
DR   eggNOG; KOG1215; Eukaryota.
DR   HOGENOM; CLU_223673_0_0_1; -.
DR   InParanoid; B3S5U0; -.
DR   OMA; NDWLRSK; -.
DR   OrthoDB; 2905895at2759; -.
DR   PhylomeDB; B3S5U0; -.
DR   Proteomes; UP000009022; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd00112; LDLa; 15.
DR   CDD; cd06263; MAM; 20.
DR   Gene3D; 2.60.120.200; -; 20.
DR   Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 15.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR036055; LDL_receptor-like_sf.
DR   InterPro; IPR023415; LDLR_class-A_CS.
DR   InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR   InterPro; IPR000998; MAM_dom.
DR   PANTHER; PTHR23282; APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR; 1.
DR   PANTHER; PTHR23282:SF101; RT07201P-RELATED; 1.
DR   Pfam; PF00057; Ldl_recept_a; 9.
DR   Pfam; PF00629; MAM; 20.
DR   PRINTS; PR00261; LDLRECEPTOR.
DR   SMART; SM00192; LDLa; 15.
DR   SMART; SM00137; MAM; 20.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 20.
DR   SUPFAM; SSF57424; LDL receptor-like module; 15.
DR   PROSITE; PS01209; LDLRA_1; 8.
DR   PROSITE; PS50068; LDLRA_2; 15.
DR   PROSITE; PS00740; MAM_1; 1.
DR   PROSITE; PS50060; MAM_2; 20.
PE   4: Predicted;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW   ProRule:PRU00124}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009022};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..4197
FT                   /note="MAM domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002798514"
FT   TRANSMEM        4108..4130
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          23..178
FT                   /note="MAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50060"
FT   DOMAIN          180..340
FT                   /note="MAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50060"
FT   DOMAIN          342..507
FT                   /note="MAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50060"
FT   DOMAIN          528..689
FT                   /note="MAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50060"
FT   DOMAIN          691..854
FT                   /note="MAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50060"
FT   DOMAIN          856..1020
FT                   /note="MAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50060"
FT   DOMAIN          1064..1224
FT                   /note="MAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50060"
FT   DOMAIN          1270..1431
FT                   /note="MAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50060"
FT   DOMAIN          1464..1628
FT                   /note="MAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50060"
FT   DOMAIN          1674..1835
FT                   /note="MAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50060"
FT   DOMAIN          1887..2046
FT                   /note="MAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50060"
FT   DOMAIN          2091..2253
FT                   /note="MAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50060"
FT   DOMAIN          2305..2465
FT                   /note="MAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50060"
FT   DOMAIN          2511..2673
FT                   /note="MAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50060"
FT   DOMAIN          2739..2912
FT                   /note="MAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50060"
FT   DOMAIN          2957..3121
FT                   /note="MAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50060"
FT   DOMAIN          3187..3364
FT                   /note="MAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50060"
FT   DOMAIN          3404..3566
FT                   /note="MAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50060"
FT   DOMAIN          3626..3791
FT                   /note="MAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50060"
FT   DOMAIN          3838..4000
FT                   /note="MAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50060"
FT   REGION          4157..4197
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        4168..4182
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        1048..1063
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1251..1266
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1634..1646
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1641..1659
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1653..1668
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        1870..1885
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        2072..2087
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        2289..2304
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        2479..2497
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        2491..2506
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        2722..2737
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        2919..2931
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        2926..2944
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        2938..2953
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        3169..3184
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        3362..3374
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        3369..3387
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        3597..3615
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        3609..3624
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        4039..4054
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT   DISULFID        4081..4096
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ   SEQUENCE   4197 AA;  458650 MW;  6993AF4D9D485FDD CRC64;
     MAAKMIALGL LLLLAVASSQ AQFNCTFESG FCGWTQPVNA PLNWTLNNGS TASFGTGPSQ
     DHTTGSGLYI YIEASFVQSN ILATLLSPLV TSGQACLTFW YHMYGPDVAT LNVSTTVNNQ
     DSLLWQRSGT QGNKWQLARI QFSPNTNYQI KFVAKRGSGF AGDIALDDIS MIPKACPLTT
     NCDFEIGTCK WVQDQTDGFD WIRGRNGNDQ NGQGPPMDHT LQSPVGYYLY TSSSSNPDKT
     ARVMISPPFP PTPPIGKCMN FYYRLTANAG TLRVFNQING ARGTPLWQES GNQQGLWKPG
     QVTMNSTSGT WQPVFQAETA NGQGTIAIDD VSFFDQACPP PGNCNFENGY CTWMNAIAGD
     NFDWIRHQGS VPSTLTGPLS DHTLGTANGY YIYMEATGRQ RGQKTVLQSM VFPPAPNGRC
     LSFWYHMYSP FAFGQASSLS IYIQKVGSNF GSILWLRNSS AGDVWHNAHV AFSSSQSYQI
     LIVATRGQSS LSDVAIDDIS FTTTCNASFT RPTPKPTQAS TALPSTSYDC TFENGFCTWT
     QDLTDSLNWT RHQGPTSSSD TGPRVDHTTS STSGWYAYVE GSHFFSNNTA RLISATITPT
     TGPMCFRFWY YMFGEDIDTF NVYFKFGNVL GSKVWTRKGN QGPSWKLAQL QFQQSIPFQL
     VLETTHISGN YRSDIAVDDI KFNFQQCPPR SLCDFEDSSR CGYTQDINDN FDWTYFTGAG
     VAGQWSPIND HTTYTSSGHS FFANMKSQST GAVARLNSNE QPPTAGSCLS FWYIAYGSNY
     GSLSVYTQIG GTLNKIWSVP TTGITEAARA WLGMQVTVQS QQPYFITFEA ARATGINGTV
     AIDDVNISPG VCPPLGDCSF EKGTCLWRNA VSLDKLDLLR WSGPTPTAGT GPSSDHTLGT
     DAGHFMYLES SLASKGDNAI FFSPEFGPRS TPRCFTFWYH MYARNKDQMG SLLVVFSDIN
     SNSVIKNITG YQGPKWNYAA VPLQSSTLPH WVAFDLIRGS GSYSDIAIDD VIFYDGACPT
     EPATPSPNPC AVRCYSDFSK CIPSNQVCDY NMNCPDGRDE LNCGGCSFES NTCQYTINAG
     SDTWVRGKYD TPKGNIMPQV DHTTKSTTGW YMLVTDATGL NFGDAKLTSK KLPPTSATCQ
     VRFWYFSYGN STRTSDLDVS FIEGPIPKTR MIKIRNVNSN KWQQGIAYMG RRVQPYQLTF
     EGSRDFLGRS YMAIDDISMY ECGMPPKLPS CSSNQFHCGQ TKACVDSNLI CDFQDDCGDG
     TDEAQCAAFN GCNFENGICD WSQVSGSDDF NWDRTSGTTF TSYTGPSRDH TTGTVTGYYL
     YIDGFFESAG AKAQLKSKWF QPNTSGKCKI RLWYHMRGTG IGALNVYAVP NGGKLIKIWS
     RSGQLGDVWL RMEAPVVSSR YFYFMIEAVR GSSDESDIAI DDISFTTDCK YASGTVPSVP
     TGTLPTIVPS QVPSCSSWST PNCGSCNFDQ GQCGWRDTSI GGISGWIRDS AGNGQSFNGP
     LYDHTSNSGL GYYMYTKAKG GSFLTDSKLT SPMMPAAYDT CTISFWYNKT ISSTLGLYVV
     QNGTSTRLWR SSFSFITNPN EPLWANASAG IGHRSQGYKL EFRISGSSFS TSNGVAAIDD
     ISFTGCNMPP SVPCFSGNFQ CKNGRCVSPS VVCDFANDCG DSSDEIGCAA ALPWSCNFEK
     DDCGLIQDQT DTFNWRRDFG GTFSSLSGPN FDHTLASSKG YYMFFSARSS SLNKTARQTI
     PQTFGTPGTG CQMRFWYHMF GPDIGGLNIY ARTNFMGPLI KQYSIIGNQG DIWKKASLTF
     SVNAPFQVVI EAVNGKYLWG DIAIDDISFT SGCTKVNTPL PYAQQTDPGC PTGQRRCGTT
     GPCKPSSVFC DFRNDCGDNS DEASCPSSCT FENGMCGWKS PKELGDIQWR RNRGGTPTQF
     TGPTTDHTNG NGWYMYVEAD NGTFSDNAYL ISPFYQNPGL SCTLSFWYHM YGFDIGSLKV
     QIASPTGTKQ LWSKSNGQGN KWIQATNIPI PRCASAFQIS FIGSTDFFGT AGDIAVDDIS
     LNNCLKTTQT TCASGQLKCA DNSACYPVSS KCDFGQDCCD SSDENSCTGY TRCNFENGLC
     GWMQLKSDNF DWEAEQGSTI SSGTGPQADH TTGTSTGTYY MIETSFPQSP NETASLGSPI
     LSPTSSGCIM RFWYNMLGPD VGSLTVSTRT SYTGSMSQQW SKSGNQGPSW IKASVNLPTS
     SAAYQVVITG KVGPSFQGDI AIDDISFTPG CKFGGVLPGQ PTASPTPAGQ CTTFSCDAGS
     KCLAMSSICN FVTECSDGSD EANCGSCTFE TGQCGWQNSY TDNFNWTRRQ GSTPSISTGP
     SYDHTTFSTS GWYMYTEVSG GRIGHRADLR GPLIQPVPAT CKFTFYSHMY GQDIGSLALY
     MLNAQGQRIA QLWGLSGNRG NYWSRTAVTI GRRQQPFRLQ FEALRGSGFQ GDIALDDLLF
     SSCKVPTQCV TPSSSQIVCP NSFCISKDLL CDFSQDCLDG YDETNCVNYQ QTCNFQAGFC
     GWTNLKDDDF DWSITNGPAA TPNTGPYRDH TLGTYSGNYA YADGSRRNFN DIARLASKPI
     AATTSASNCR IRFFYNMYGS RVRYLRVRYR TSIGGTYTTR LSLYGNKGPS WLRASVPLIS
     SKPFQVVIEA AVSSSFTSDI AIDDISLTPG CQLFTGTFPV TATSTPAPLT TSTPTQRAPN
     TCSSTQFGCY NNGNCIPKSK TCDFIADCGD GSDEWACPSQ CDFEKNMCGM TVTQSTNPLY
     TFKWQYALAH DAAEKQSIRS DHSTGTGNGH YVYYGGVIAP TNPSAGVPYN NLRTNITTGM
     YQHASSQCLL QFWYYYNGNS PGRLQAHILN QGDTQPTILW ETQGTISSGW RNATVGIGAR
     TKPFQIIFYG FHFVAFDGAV AIDDVNFINC AYAPSQPTCS LGQFRCQRGS CIPNDQVCDM
     TNDCGDNSDE ASCSTYKQCN FETPNCAYLT QDLVTDQLNW TRRAGPTFSV YTGPSRDHTL
     GTYKGYYYYL ETSGLLQYGQ VANLLSSVFD LTSTSNCRMT LYYHMYGQTI GNFAILTRTQ
     SNGTMTQLFA RRGPQGDIWR KVTVTLPSGK LTQLVIQATV GDSFSGDIAI DDVSFTSTCK
     STTQSLPYAP PLPPTSAPPP TTAVSHTCNL NTQFNCRSTG KCILLSKVCD FRQDCADNSD
     EVACIQQTCS FEQSMCGWQS QSVNGAFTSV NSTAIKFKWE RHNGATHTGS TGPSVDHTLG
     TSQGYYVYTD ASFGRFTDVA ILTSPIIGGT GSQCVVSFWY HMYGSHVGRL SLNAKRGNTL
     TQLWTRNGGR ANTWYQVSVK VGQRQSFQLQ FRGTRSFLYN GDIALDDIKL NNCIQPIRQP
     VCPQTTFTCG NGYCVDPKYV CDYANDCGGL QDETNSVCSK NAMGRCGFEL DECYFYLDTP
     NKPNWIRRTG LIFNGPSGDV DTGASTGHYM NLNTYYPALS GDVSRFASQP FKAASSNANC
     YLRFYYFMLP ATNGGQLNVY TRTSASANGM NTIFSVANAS VNYWNRVAVK IVSSAPFQVV
     FEGVVGTRYS ARIGIDAISF TSGCAFGGNI QIPGITVRPP NSGFPTPGCS SNSSFGCKNG
     KCIPRSSVCN FKNDCGDNSD EANCGTNCNF DTGTCGWYNA GYGSRRNWTR TLAGSNPISR
     APKIDHTSNS SSGYYMYMRP MTTGASSINR YVGMLESALY AASSPQCTMS FWYAKYRIYT
     YYFIGVYVQT STQTIQMAYF TNGDSKGTAW QKATVNIGIQ QNFRILIGGS TGSSRLYGLA
     MDDIQFNNCF TTQRACTRQE FKCATSGQCI SKLWQCDRQN DCPDGSDEAP SACKYNYADC
     TFDTGFCNFT NLLNGDFNWT RAMTTNSGST GPNNDHTTQS TSTGYFVFTE ASFPRNDYDT
     AFLAGPTLPA SQGVCWIKFW YNMYGASMGT LKVVIMDVTL NRTLSVVWQK SGNQGQSWYR
     GNAMLNSAQP FRAVFQGVLG TSFTSDMAVD DVVFTPGCYV GGSPIVPLPL VNNQCNNPSY
     TFSCPINNKT VCIPNTWRCD GIIDCNNAMD EDRCGVLNRP CTANEFKCGN NGGCINSTLH
     CNGFPDCYDS SDEAGCPQIG SQTANGGAIA GAVIGSLIAV ALIGGIFYMY RADKLGSVTQ
     IFTKRTLGNQ NYEAYQDDDK EPTLRDFSET TESNSGDGQT AVANPLYESK DDADIYQ
//

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