ID   B3S915_TRIAD            Unreviewed;       885 AA.
AC   B3S915;
DT   02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   02-SEP-2008, sequence version 1.
DT   27-MAR-2024, entry version 60.
DE   RecName: Full=Death domain-containing protein {ECO:0000259|PROSITE:PS50017};
GN   ORFNames=TRIADDRAFT_60663 {ECO:0000313|EMBL:EDV20798.1};
OS   Trichoplax adhaerens (Trichoplax reptans).
OC   Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC   Trichoplax.
OX   NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV20798.1, ECO:0000313|Proteomes:UP000009022};
RN   [1] {ECO:0000313|EMBL:EDV20798.1, ECO:0000313|Proteomes:UP000009022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV20798.1,
RC   ECO:0000313|Proteomes:UP000009022};
RX   PubMed=18719581; DOI=10.1038/nature07191;
RA   Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA   Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA   Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA   Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA   Rokhsar D.S.;
RT   "The Trichoplax genome and the nature of placozoans.";
RL   Nature 454:955-960(2008).
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DR   EMBL; DS985257; EDV20798.1; -; Genomic_DNA.
DR   RefSeq; XP_002116739.1; XM_002116703.1.
DR   AlphaFoldDB; B3S915; -.
DR   STRING; 10228.B3S915; -.
DR   EnsemblMetazoa; TriadT60663; TriadP60663; TriadG60663.
DR   GeneID; 6757870; -.
DR   KEGG; tad:TRIADDRAFT_60663; -.
DR   CTD; 6757870; -.
DR   HOGENOM; CLU_015649_0_0_1; -.
DR   InParanoid; B3S915; -.
DR   OrthoDB; 36592at2759; -.
DR   PhylomeDB; B3S915; -.
DR   Proteomes; UP000009022; Unassembled WGS sequence.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd01670; Death; 2.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR032171; COR.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR016729; FADD_DD.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR15077:SF9; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; 1.
DR   PANTHER; PTHR15077; FAS-ASSOCIATING DEATH DOMAIN-CONTAINING PROTEIN FADD; 1.
DR   Pfam; PF16095; COR; 1.
DR   Pfam; PF00531; Death; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS50017; DEATH_DOMAIN; 2.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000009022}.
FT   DOMAIN          1..40
FT                   /note="Death"
FT                   /evidence="ECO:0000259|PROSITE:PS50017"
FT   DOMAIN          813..879
FT                   /note="Death"
FT                   /evidence="ECO:0000259|PROSITE:PS50017"
FT   REGION          197..249
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          770..790
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        209..224
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        233..248
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   885 AA;  102037 MW;  46414A7BA0200AF3 CRC64;
     MAFLKKWHTK YGLSATIDRL NDALLRIGKS GMVDEINRDQ AFLRLNELEK QERNAMSKII
     EEKEYKEAYA KARKEGSCRN DFIRFLITGP QNVGKSCLIQ AFTRQGLIGK IGPTTAAVVT
     KELIKLLTYN VDNKSVDEFI SVLARKVVTA IETIKYQMKL EKSLSDFSSY DTRQAIQLSQ
     VLSDYYKSVL EDEESTFSES VSADEESTFS ESVLEDEEST FSESVSADEE STFSESVLED
     EESTFSESVS ADEETIPLEF LENYFRGHYE SNQNIGIDDC HYGKLWDFAG HSIYHITHQP
     FISCNCIYML VLDMSQDIDK YVVDRDGNDT EMTYLEAIQE WLASIIGSST SNARTVTEIN
     GTLENIAWPI VILVGTHADK IGDNNACQQR FSKFSRCIHN KLPSYSDHIY GSKIIFNCND
     EDNGEEVRLQ RQKNCGQLHN IMRDFVNHQP SIDHFSQIPF KWYIMAAILH TSLDRFNEQA
     AKFSTKLNQK ISRIMAAEEI EQLAKEYQLC DGSEDIHQML LYLHDLGEIV YCQKESAKGK
     VITQVEWLLN IFRTIIQLDE PVCKGLRINA EYEAARDSGI MSSRYINDQF DKLEVEEKDR
     KFLLDLMESY DIICKISNEN DNCPDQYFVP YLFRSNSQEF DDKGYKTSGW LYIGFKPPQM
     PYIPDGILFC LLVSCYKEWQ SSEIEPRYKC AKYRLKEYCC DIIVKKESSW IGIKYRYRMM
     SNKPSLQRQI EDKMLLTRRK SVDITPVVQE SISSQQGGTT TQNGIKPVMQ ESTTSQQGET
     ATQNTMDPIQ DDSNRRSIFI DIADKIESTK LAEFGRKLHL SSNSINEIVD SNNSRFWKVD
     RLLEAWYSEF SSTTKLDTLL KVLCECREGK MAEKLKEEYC IQRKE
//