ID   B3S9T3_TRIAD            Unreviewed;      1306 AA.
AC   B3S9T3;
DT   02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   02-SEP-2008, sequence version 1.
DT   27-MAR-2024, entry version 72.
DE   RecName: Full=Nephrocystin-3 {ECO:0000256|ARBA:ARBA00040387};
GN   ORFNames=TRIADDRAFT_61019 {ECO:0000313|EMBL:EDV20526.1};
OS   Trichoplax adhaerens (Trichoplax reptans).
OC   Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC   Trichoplax.
OX   NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV20526.1, ECO:0000313|Proteomes:UP000009022};
RN   [1] {ECO:0000313|EMBL:EDV20526.1, ECO:0000313|Proteomes:UP000009022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV20526.1,
RC   ECO:0000313|Proteomes:UP000009022};
RX   PubMed=18719581; DOI=10.1038/nature07191;
RA   Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA   Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA   Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA   Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA   Rokhsar D.S.;
RT   "The Trichoplax genome and the nature of placozoans.";
RL   Nature 454:955-960(2008).
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DR   EMBL; DS985259; EDV20526.1; -; Genomic_DNA.
DR   RefSeq; XP_002116952.1; XM_002116916.1.
DR   EnsemblMetazoa; TriadT61019; TriadP61019; TriadG61019.
DR   GeneID; 6758233; -.
DR   KEGG; tad:TRIADDRAFT_61019; -.
DR   CTD; 6758233; -.
DR   eggNOG; KOG1840; Eukaryota.
DR   HOGENOM; CLU_282186_0_0_1; -.
DR   InParanoid; B3S9T3; -.
DR   OrthoDB; 4130451at2759; -.
DR   PhylomeDB; B3S9T3; -.
DR   Proteomes; UP000009022; Unassembled WGS sequence.
DR   GO; GO:0097546; C:ciliary base; IBA:GO_Central.
DR   GO; GO:0097543; C:ciliary inversin compartment; IBA:GO_Central.
DR   GO; GO:0060271; P:cilium assembly; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd01670; Death; 1.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR   InterPro; IPR032171; COR.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR45641:SF1; NEPHROCYSTIN-3; 1.
DR   PANTHER; PTHR45641; TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870); 1.
DR   Pfam; PF16095; COR; 1.
DR   Pfam; PF00531; Death; 1.
DR   Pfam; PF13424; TPR_12; 3.
DR   Pfam; PF13176; TPR_7; 1.
DR   SMART; SM00028; TPR; 10.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF48452; TPR-like; 2.
DR   PROSITE; PS50017; DEATH_DOMAIN; 1.
DR   PROSITE; PS50005; TPR; 4.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000009022};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW   ProRule:PRU00339}; Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT   REPEAT          182..215
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          224..257
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          266..299
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          350..383
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   DOMAIN          1226..1297
FT                   /note="Death"
FT                   /evidence="ECO:0000259|PROSITE:PS50017"
SQ   SEQUENCE   1306 AA;  152135 MW;  1265DF0E5A7173AF CRC64;
     MRHQTRPNPN DYLKPLVDIG FNHFNKGEFD QARICFEKAL QKIQEIGHTS ISHDRLKFDL
     YLQISQTYYK QLKYNDAIEF CQKAENMART FKHRLHIAQA LESRGKIKVK QQLFHAALDD
     YNEALQLKIA VHGSKHIDVA DSYHAIAEIH VLQHQYNHAL TLQENGLKIR LNKMGRDHFL
     VAQSYYSIGY TYYHLQQYDK ALKNYKNCLN IRLKKSDNDY LGLAETYNGL GETYFKLHDD
     ESAISMYQKS LNLKVSVFGD YQIENSNLYY RLSVVYLRQK QFEEAFFAIQ KCLKIKLEYD
     GNNHIDVAKC YNTIACIYTG QGLYHDSAMM FRKSLQIKLN IAGYDQFDIA DSYHNCGNAY
     LKIEEYQQAL LMYQKSLFIL LQIAKNDSHR KHIADLYRVI AKVYSYQCKD AEAIVMLEKY
     CNIILSQHGE CQKVAAIYKE IASKYEKLHQ QNEASRMHQE ALRIIKNFSD ENDSPKSIAL
     AQHAIGDPNY YKAFMKVLKD EKCRSDCTPI VFVGPENSGK TSIMKLFSRQ ELIPNLMPTQ
     IIDNPGIMID LNSYKIFDSD TCDIGRILDR KVVAAIESTK WGMIYQEDMK DSNHSKSSIA
     KTADDSRLNN EKIQASLITP NQLHEESIGN LKPYGDHDYL SNAYTKPVNL KHYLDIFNNY
     YEHSLVIESD VKTHGYNCGK LWDFGGNPMH WIAHQPFMSG NSIYILTYNI AQDINQIVQT
     TDIDPNKMTY LQTIEECITN IVGRHSNQNR IEPCDDDNSD YDNDGISNEY SLPVIILVAS
     HGDCVQNIEE QRRLFEGFEQ ALLASLPQYE KHICSSSIIF NCDPHDTSPA TISQRKQSCH
     HLQQIIQRFY NSLPLLKNFI PIRWQIMSNL ILKSSNRSYH QVNSILVDKI NKIMFVNEIK
     QLSIDCGLYQ GDQDLHDMLK SLHNLGDILY FQDNQGEGII ITQIEWLSDI FRRLFTMGKN
     ARKVIGRRFL INYAARFKGK IPQSYLDNIL KKISITDKHK QIIYHLMEKF DMIYPMEKDE
     NDNSDDLYYF APFTVEPRIS LGHINLARYH VSDWLYIGYD QNELSFIPTS VFISLLVACF
     KQWKNSKVEL YYNCVKYYVK ANQYSYYLIV KKAKRHIGLR YYCEKESNAT KDNITKVIDE
     TRPQDFVYSQ LIAILKEKLP TINCNNCQFS IQCHCNEMVT LNGLDQRDYE AIECHYCHQI
     VRTHYLKDWT IYTRNSEVPQ CYFFKISKHI GIDWTKLAAK LDANIDVDTI KVENQTVFDR
     ALKLLNEWFN RNCSSNATQN LITALRDIDR YDILLKLGIS GNKLDM
//