ID   B3SB46_TRIAD            Unreviewed;       977 AA.
AC   B3SB46;
DT   02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   02-SEP-2008, sequence version 1.
DT   27-MAR-2024, entry version 72.
DE   RecName: Full=APAF-1 helical domain-containing protein {ECO:0000259|Pfam:PF17908};
GN   ORFNames=TRIADDRAFT_61487 {ECO:0000313|EMBL:EDV20044.1};
OS   Trichoplax adhaerens (Trichoplax reptans).
OC   Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC   Trichoplax.
OX   NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV20044.1, ECO:0000313|Proteomes:UP000009022};
RN   [1] {ECO:0000313|EMBL:EDV20044.1, ECO:0000313|Proteomes:UP000009022}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV20044.1,
RC   ECO:0000313|Proteomes:UP000009022};
RX   PubMed=18719581; DOI=10.1038/nature07191;
RA   Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA   Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA   Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA   Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA   Rokhsar D.S.;
RT   "The Trichoplax genome and the nature of placozoans.";
RL   Nature 454:955-960(2008).
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DR   EMBL; DS985263; EDV20044.1; -; Genomic_DNA.
DR   RefSeq; XP_002117428.1; XM_002117392.1.
DR   AlphaFoldDB; B3SB46; -.
DR   STRING; 10228.B3SB46; -.
DR   EnsemblMetazoa; TriadT61487; TriadP61487; TriadG61487.
DR   GeneID; 6758641; -.
DR   KEGG; tad:TRIADDRAFT_61487; -.
DR   CTD; 6758641; -.
DR   eggNOG; KOG4155; Eukaryota.
DR   eggNOG; KOG4658; Eukaryota.
DR   HOGENOM; CLU_304262_0_0_1; -.
DR   InParanoid; B3SB46; -.
DR   OrthoDB; 2937210at2759; -.
DR   PhylomeDB; B3SB46; -.
DR   Proteomes; UP000009022; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:UniProt.
DR   Gene3D; 1.25.40.370; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR   InterPro; IPR041452; APAF1_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR22845; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; 1.
DR   PANTHER; PTHR22845:SF5; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; 1.
DR   Pfam; PF17908; APAF1_C; 1.
DR   Pfam; PF00400; WD40; 5.
DR   SMART; SM00320; WD40; 9.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 2.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000009022};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW   ProRule:PRU00221}.
FT   DOMAIN          225..346
FT                   /note="APAF-1 helical"
FT                   /evidence="ECO:0000259|Pfam:PF17908"
FT   REPEAT          463..504
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          505..546
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          633..664
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ   SEQUENCE   977 AA;  111642 MW;  A3E5F5C7C25B38D3 CRC64;
     MTENQPIRPF VVLDDVREAN QLLYLNFNCD TIVTTRNADI ASKLNREKCV IHIKELLTVE
     HCRNVMASTA KIPISTLPKA VDQFIEIVDH SALILTLFGI LVQHDKDKWN ISDNKWLNQY
     QSQYDTKTML HKLIDMLLSN LNESDLNLIL KLDIFEENTI IPINTLSMYW GVNQHYCISI
     MNSLVHRFLA TENVVNTKNI GYSLNDYMAD YIRSRHCVSD AKANHVTLLD LYKKSCQGDW
     VQLRNDDYIH DHLVDHVIGA DDKKTMKELL TNFKWLQIRL KNKSSYALLH DFIKSRSILD
     FEEWNHLHDY WYLVRDSHSS INLCQDGSLI QLALSRPWWR DFYKEVESKA IEDCKETTFF
     KWNNCYNQRN EFQICIATLE PTSESITSSC FSSDGTMLAC CDKIGNIIIY DTILWTPLYS
     FHSTKGKISN CSFSPDCQKI ALSFHCGKTE VWNINNEKIL IEHGYHTAKV NWSEFSPSGQ
     EVVSCSDDRL IMIWNSNTGN NIVTCRGHKN MVIDCHYSKD GGRILSCSWD KTIQIWDTTF
     GTSLLVCAIT EDWPIFCSFL DHDQHIMCGC EHRVYIWDSS TGDAIDKLTS TCRDRVSLYD
     VTANGKMAVR CLFGSNLVEV IDTSSGQTSI VTDDGHHDLI TCAKISPNSK IIATTSKDTL
     LKLWLVQPFK ENMEKADKKP MHLLDCSFIG NVPHIISGEY EQWEGQAIEV LFWDTFVFDC
     GKDVRFVKET CKEDWKCVKC CSLSHNGNLL AVGFAFGKVK MLHHDNLEVD WSINNLQLHV
     NNLTFNSTDE VLMIVNSING DIVNKFISED QICFYKFLES SNILLIGAAR GEMQAYNIYE
     NSKSIDSLSI PGKIIHHDLA LDDAECAVIL EDKDSKACIV WNCVSFKITH TVDSNTCIST
     CKFSTKCDKL AIGYDYGTFK IWETTSWTLL TSFDGHLGSI QTLYFSADDK IILTGGNQER
     NNAGDYISNH FSHKGLL
//