ID B3SBN3_TRIAD Unreviewed; 414 AA.
AC B3SBN3;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=WW domain-containing oxidoreductase {ECO:0000256|ARBA:ARBA00016094};
GN ORFNames=TRIADDRAFT_32795 {ECO:0000313|EMBL:EDV19893.1};
OS Trichoplax adhaerens (Trichoplax reptans).
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV19893.1, ECO:0000313|Proteomes:UP000009022};
RN [1] {ECO:0000313|EMBL:EDV19893.1, ECO:0000313|Proteomes:UP000009022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV19893.1,
RC ECO:0000313|Proteomes:UP000009022};
RX PubMed=18719581; DOI=10.1038/nature07191;
RA Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA Rokhsar D.S.;
RT "The Trichoplax genome and the nature of placozoans.";
RL Nature 454:955-960(2008).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Golgi
CC apparatus {ECO:0000256|ARBA:ARBA00004555}. Lysosome
CC {ECO:0000256|ARBA:ARBA00004371}. Mitochondrion
CC {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|ARBA:ARBA00006484}.
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DR EMBL; DS985265; EDV19893.1; -; Genomic_DNA.
DR RefSeq; XP_002117635.1; XM_002117599.1.
DR AlphaFoldDB; B3SBN3; -.
DR STRING; 10228.B3SBN3; -.
DR EnsemblMetazoa; TriadT32795; TriadP32795; TriadG32795.
DR GeneID; 6758869; -.
DR KEGG; tad:TRIADDRAFT_32795; -.
DR CTD; 6758869; -.
DR eggNOG; KOG1208; Eukaryota.
DR HOGENOM; CLU_010194_44_0_1; -.
DR InParanoid; B3SBN3; -.
DR OMA; VHPGNMV; -.
DR OrthoDB; 2466675at2759; -.
DR PhylomeDB; B3SBN3; -.
DR Proteomes; UP000009022; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR002347; SDR_fam.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR24320; RETINOL DEHYDROGENASE; 1.
DR PANTHER; PTHR24320:SF269; WW DOMAIN-CONTAINING OXIDOREDUCTASE; 1.
DR Pfam; PF00106; adh_short; 1.
DR Pfam; PF00397; WW; 1.
DR PRINTS; PR00081; GDHRDH.
DR SMART; SM00456; WW; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF51045; WW domain; 2.
DR PROSITE; PS01159; WW_DOMAIN_1; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 2.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000009022};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT DOMAIN 22..55
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 64..97
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 414 AA; 46232 MW; 9F8317889CAC7B5C CRC64;
MQVSNLYSND ADTTSSDADS DPELLPGWEK SKTSTGRTFY VDHNTQTTQW EHPQRSHKKP
HQKIDLPFGW IQIKNENGTI LYVNQRNQKK TYVDPRLAFR MKKNRRVFDA VSTSMDVLQG
RNLSGGIALI TGATSGIGFE TARALALHGA LVIMGCHDIV KGSIAAKKIT KEEPLAKIDV
IEVDLSSLKS IACLADEVLK KYRQLHVIIC NAGVLGLPWR LTTDELEYTF TVNYIGHFYL
VKLLTELLIS SSPARVVVIS SESHRFPTTD GSSFNVENIL PSKQQFIPME AYNQSKLCGI
LFSNEFNRKY SCYGVTSNAV HPGNLLPTSL CRNSWFYTIL FLLARPFAKS TVQGAATTTF
CAAARELNGV GGSYFNNCQR CDPSPESQNE ELARALWKYT ESLLSCRTIR LLPQ
//
