ID B3SCB9_TRIAD Unreviewed; 3527 AA.
AC B3SCB9;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=Spectrin beta chain {ECO:0008006|Google:ProtNLM};
GN ORFNames=TRIADDRAFT_33212 {ECO:0000313|EMBL:EDV19636.1};
OS Trichoplax adhaerens (Trichoplax reptans).
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV19636.1, ECO:0000313|Proteomes:UP000009022};
RN [1] {ECO:0000313|EMBL:EDV19636.1, ECO:0000313|Proteomes:UP000009022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV19636.1,
RC ECO:0000313|Proteomes:UP000009022};
RX PubMed=18719581; DOI=10.1038/nature07191;
RA Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA Rokhsar D.S.;
RT "The Trichoplax genome and the nature of placozoans.";
RL Nature 454:955-960(2008).
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DR EMBL; DS985269; EDV19636.1; -; Genomic_DNA.
DR RefSeq; XP_002117874.1; XM_002117838.1.
DR STRING; 10228.B3SCB9; -.
DR EnsemblMetazoa; TriadT33212; TriadP33212; TriadG33212.
DR GeneID; 6759087; -.
DR KEGG; tad:TRIADDRAFT_33212; -.
DR CTD; 6759087; -.
DR eggNOG; KOG0517; Eukaryota.
DR HOGENOM; CLU_224751_0_0_1; -.
DR InParanoid; B3SCB9; -.
DR OMA; LWCQRNT; -.
DR OrthoDB; 2872403at2759; -.
DR PhylomeDB; B3SCB9; -.
DR Proteomes; UP000009022; Unassembled WGS sequence.
DR GO; GO:0030054; C:cell junction; IBA:GO_Central.
DR GO; GO:0042995; C:cell projection; IBA:GO_Central.
DR GO; GO:0030864; C:cortical actin cytoskeleton; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0030036; P:actin cytoskeleton organization; IBA:GO_Central.
DR CDD; cd21193; CH_beta_spectrin_rpt1; 1.
DR CDD; cd00176; SPEC; 18.
DR Gene3D; 1.20.58.60; -; 18.
DR Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001589; Actinin_actin-bd_CS.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR11915:SF435; SPECTRIN BETA CHAIN, NON-ERYTHROCYTIC 5; 1.
DR PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR Pfam; PF00307; CH; 2.
DR Pfam; PF14604; SH3_9; 1.
DR Pfam; PF00435; Spectrin; 19.
DR SMART; SM00033; CH; 2.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00150; SPEC; 26.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 24.
DR PROSITE; PS00019; ACTININ_1; 1.
DR PROSITE; PS00020; ACTININ_2; 1.
DR PROSITE; PS50021; CH; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000009022};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 15..118
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 132..237
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 816..873
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 778..807
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1079..1100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 496..556
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 983..1010
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1746..1798
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2137..2174
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3110..3144
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3216..3250
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3320..3347
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 778..793
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EDV19636.1"
SQ SEQUENCE 3527 AA; 415508 MW; 51DFE6991725EC7A CRC64;
FGSSRIQELQ QERINIQKKT FTKWMNSFLE QTPFKIGDLF EDLGDGKALH RLLEDITGNS
LGRMNSGRLR VQKMENVSKV LSYIRTMVKL ESIGAEDIVD GNPRLVLGLI WTIILRFQIQ
EVQLDDESAE QRSAKEALLL WCQRNTTGYP GVNVKNFTSS WSNGLAFNAL IHHFRPDLID
FRSLPPEKHL DNLENAFRVA EKDLGIHPLL DPEDVDVVRP DEKSIMTYLI AYYQYFAKMR
TEKTGGKRIG KIIGLIMEVE KMVKDYYMSI DDLLKWISKT IETLSERNFP NTIERIKKEM
IKFNQYRTTE KPPKLSERSN LEVLFFNIQT KLRANNQKVF TPNEGKFISD INRAWEKLEK
VEHGREIALR QEMQRLEHLE NLAAKFGKKI GLHEDWLSDM DILLDESLQY NDKRSVEISI
QRQEAIENDI QGREDRFMRL FSLADELVNG NYHGADDIRQ KTEKLQTRWH DILAKLRPRQ
LIADALKELL VLYREIESAT FELEDLDKRL STKESNQSSL NVEALLERHN LIEKELETLR
ERIDKTSHKI QNYIRSGNPE YTKLRDKHTQ LVRLYNTITD LCLRKRETLS EFLEFRSYRR
SAEAELGWLK EKEQDFRTAS LAKDLSNVPR MQKKQELLVS EMHARRPMFE KTMDDAEKAS
KLNNIDAEKL KDIISEARSK WQTLSRLSQE RLKYLIDIGQ LQQYLADCDD AESWINGKLP
LVSNTDYGRD ESNTETLLQN LSMVRNDVDN FDEDMQRLSN LCRSVIEMLE GLPSTPVQQQ
QQQQQQQMKQ EHIPIQTLDD IDPEESSDGK EMLTEIEVPQ VRALYPFEGK SMTMARDEVL
LLMDKSHPDW WIVKNDEGRV GYAPANYIKE IAPRVLYHVS KDPKSSKKLR KEAKKELNSK
PQQITAAVDL SLLPSINDIR EKQRHLQGLY QQLRSLTGQR YDRLTFTHYY HGFKRDCDDI
EDWINQQITT LSNPIYQSNL DHLSHLEKAF EQLERQLPSK QAQLKTIQDA GKDIIISKKY
RQFDDEIVKS IDHVNQRWQV LLALKNQTGK NIQNLIGVRN VIQQCDELKL WLDQKQSDLT
QDQDDPDQAY SPNETKKYHH QHLDLQKDIA RGQRDMDHLS KLIQELAIEE PQLQQQVQSK
WSELNSIWDQ MQQQSTAKIG TLDYEFRLEQ FMRQSSDLLE WAANMESNID ISHTMIDSVR
QAEEFLEQNK ENEATVVLHR ENYTELIALG QSLKAEHPSH REQLNSRLEQ LAASQDHLNT
CWHDYCKYLS NCLDWQLLNR DYQQISKKYD AMEKLLTQYT DTSCPSNFDT IKRRYNEIEG
PLKMQDDRLT SFNNIAQALL LRGHPQDEVI TIYQRRIIER REQIWNLYDQ LYDKLVVIEE
IASYVKEVDE IIDWVSDKIH LLGQDDFYRD PSHTQSKLSK HENLEAEINA NQDHVDDIVH
YGQQLVKKYH DHGLEAKLSI DLLTEKWSEL IQQTELRRRR LEQNSQLQSF NTNMKDIDDK
ITHIEHFSQY DVDGKDIVAI RHLYQKYKEY ELQLGMINKT LQNINERCQE FVQDENYLAY
KCMQKCQRLI QRYELLSQQI VQRKLRIEAT ALFHQFNQEI HDESTWIEDR LRNLPSLIVV
TDIDGVIASQ KRLNLLQLEL TGHQEIIDQI IHGGDTLQNR SSMMKIKIQP LRNTLLTLLG
KLKTTIQDKK KYLDIEYEVL QYLSKAEELE ATMQDKLNLI HNLDHYQSED TANRSLLLQQ
SIASDSDQYS KQIKALQKEC QQIVQLDENK KDITTRKQSQ LQDKLRQLKV SNVQLKSRLT
SYLKCIYFIH QADELLAFIH NKMKLASSTD YGRNIDHVDD LWHGYEILRQ EFDLKVKTYS
DLKDLSDALI HEESPIQDQV KTARVSVMQS WTVLREEIKK RGENLESAAT THRLYMDLTD
IQHQIDSKRA VLRQDVGRNL NAVLSLLRQH ELFLNSVQAL EDKVKVTVFK VDRMHFPHLS
LLISKINQRA HDVQAQLKTL KLACDDYATR LNVSEQHYRC MNSVKDLASW AVSLNEVITS
ETTPQSRQEL MVQVSSHEAN GLEVRSKDSL IEEVLSQGQL LVNSQGRPAM DLYNALSLLR
ENSDLLKTNW SNRKQRLEQL HKYFLFEQSS QQIVHDLNDI QGKLKQQFQT LDELQQVDHR
IKEVIQQLNQ LNEIKDRIGR LSDSIQLMKD GRLSHKMTDN INHDIKPKYH DVYNHANDKL
KEAKCQHAYL DFTQRVEEVR WRLVEKDECI HEICQYYLDT PSIEIRQNHL FQSLLLPCEK
EKIEVIRHGQ KLLDTGHPLN QEIHKQIGKL QDKWHQLKSS DKKLQHCLIQ SKEMAIFNKD
AQFELLWIEE RLTIYKHPSL GHDLPQNQLI QRQLNEKEEE YRQNELYLKS IVAYGQKLID
HQHPSQDLIQ VKRDQLNYQW SLLQQSIVQF KLLLKQAGQY FSFVIDANVI IQALDKMIEV
LQNQDLGSAA DTTQTYIATY RRLEGEITIL QPRVIDFDQL ATAMLTSCPP YQEQIHAKYD
EVMIKWTQIN QLSDQRKAGL DDQQLYHQFK FEEKYCSSYM DDIDRNMNAP ELPQTLEDSE
NAIMIHNAQV NDLDKCADSL KKLDEMYQQN SHRPQAYEMK DTIQELFQRH DNLTHAWEMR
DKLLDQNRNL HIFMQRADEI EQNFNRLDEH YLTDDMVEDS IDHVDLLQKE LNEVDKNIEE
YDQDRIALEK FALTLIQSGH YDKETILKRL NSLLTIKNRI NSIYLSRRTE LEQLQEVKEF
FATCEELLLW INEKISIIND ASFSVPTNLP LKLEKRQTVE KEVAERRDDV DILINHGSNL
LWKSKHVGQS IAARLNEIDD RWHYLVDTID KLRGLLISSF NGQQLLSQCE DMINWIKEVE
SELNSNQYGH DVSSTTELLD RHHQIENQLQ NNHNQVVVLL DKIGQSLQTE HLLEDSLKNC
QQVLAESFEP LEEIAEYRGA VLEEYLRIHR FIYSCDKEVL WMKEKEPLVN STFYGKELNE
VRKLLHKHEE LQAQMNEHDV LIDAVIRFSS ELTFHYCGDQ YSLEGSDRSC QELMDRWSDF
KYKSSKRREN LQTNVEIQVL IFSMNEIETT LGDMKAEVLS ADLGVNEQMS QVLMQNLEIL
QQKLDNYHER LTNIESEINK FDEQELPELS TMKRKYASLA KLYTEVFDLA RKRHDHLNRV
LQAHQVSKEV DKLYNFLKEK ELSPVLHDPC RDLDHVENIR QKLNEFYDVL EDCRNQVENF
YESMQLLQRL NHPESHNRVL QDQLVKADDQ LHHLYELAER RKQAWILTIL SYHLHTYYHD
VDEIIHWSQE TEKNLNVDEK NAESVNLALL RNKHEQLKED LANSVNLQVE TVFSEKQYLM
QTFPDEANHI SDKHKQLSII WSHLLENIST MDGKIEQIEH YQEFSREYKD ICSWINRMMR
YLSPDLSKSW TSLEDTGKGK RTLENDISEY HDRYIQWIEF GEALLDSGHF ASNAIRDRMA
HVNELWSNLQ QEWLLHKKDL DQSVRDQVCN LGLLSLTSDL ITIRQRT
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