ID B3SCE4_TRIAD Unreviewed; 1146 AA.
AC B3SCE4;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=NB-ARC domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=TRIADDRAFT_61943 {ECO:0000313|EMBL:EDV19577.1};
OS Trichoplax adhaerens (Trichoplax reptans).
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV19577.1, ECO:0000313|Proteomes:UP000009022};
RN [1] {ECO:0000313|EMBL:EDV19577.1, ECO:0000313|Proteomes:UP000009022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV19577.1,
RC ECO:0000313|Proteomes:UP000009022};
RX PubMed=18719581; DOI=10.1038/nature07191;
RA Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA Rokhsar D.S.;
RT "The Trichoplax genome and the nature of placozoans.";
RL Nature 454:955-960(2008).
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DR EMBL; DS985270; EDV19577.1; -; Genomic_DNA.
DR RefSeq; XP_002117910.1; XM_002117874.1.
DR AlphaFoldDB; B3SCE4; -.
DR STRING; 10228.B3SCE4; -.
DR EnsemblMetazoa; TriadT61943; TriadP61943; TriadG61943.
DR GeneID; 6759123; -.
DR KEGG; tad:TRIADDRAFT_61943; -.
DR CTD; 6759123; -.
DR eggNOG; KOG4658; Eukaryota.
DR HOGENOM; CLU_257965_0_0_1; -.
DR InParanoid; B3SCE4; -.
DR OrthoDB; 3599309at2759; -.
DR PhylomeDB; B3SCE4; -.
DR Proteomes; UP000009022; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.370; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR041452; APAF1_C.
DR InterPro; IPR048975; APAF1_WHD.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR22845; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; 1.
DR PANTHER; PTHR22845:SF5; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; 1.
DR Pfam; PF21296; APAF-1-like_WHD; 1.
DR Pfam; PF17908; APAF1_C; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Reference proteome {ECO:0000313|Proteomes:UP000009022}.
FT DOMAIN 161..238
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT DOMAIN 260..323
FT /note="Apoptotic protease-activating factor 1 winged-helix"
FT /evidence="ECO:0000259|Pfam:PF21296"
FT DOMAIN 337..415
FT /note="APAF-1 helical"
FT /evidence="ECO:0000259|Pfam:PF17908"
SQ SEQUENCE 1146 AA; 133111 MW; 425C702E79CECE89 CRC64;
MASPLTPSPS TEIPLRNLPP TPTSHYVVRK EIIDIICDQL KIIDKSSGHI LVHGMAGSGK
TISVCQSVKQ AANMGWFKSN GYYWIKIGNI TNSELFNQLK ILGISLGMEW KPYIQSAGEI
CAGLSNYLKE DHYQYLTFAK KSIATSRFLF SEIELNHYCI HLPEKLTYDE AIELLALHRN
DHDAQILRNN EVVKNVIESC AGLPLAINLI GGLQLQADEA WKEAMAIIAD KSMQIQLANY
SFNLYGTLEL SANSLKNGKK ELFQDLAVFK PADIPTEAIS TLWNLSHQKT NSILMEMNNK
SLLRYITGAR CYCNIHDLMI DYLHRRINAQ TSNQDGLRNL NNKLIDGYRT KCNGEWSTIP
DDGYFYQNII HHAIVAENDE YLENFMTDLN WMTRKIRSDK TIYKLACDLG NYINYKQKKE
VLQQAWLEAN DADVIQLLLW FDMTDSRTRQ RAIQLARSAG NHSSNFIHWT IASYSTTATI
EYTYDACKGF GKNEWDDHIS LSRPQFDHLR IIVTENNKTP DCEILIKDYE RCNIINRIRP
PEPTMCITRI QISADGYSAA FQIFYEEWIV YNIDKKEQIN FINSDEREQY RNIFSSLQFC
PVIDKSYVIM TLSYDHRRVK IWEIKGSQIL PANKEISCDY EIHTCRWIMA QNTSQILLWW
RKYNRFYQES KLTESEKYMN KCQVEIWSLD PWLCQMSVTL PTIVYNKTTS DNYLATADIE
NGLALQYINY INNNGAFIIL VYSFDGKYSN YSSVVGLLKV EDILDVNTYI NEFSKHFQPI
FYPTECIRNI FVSDNQQFIA ISDKNTDGVI VLAVTKGRVQ SYAILNPSDY NQATFIPGTS
RLLVYDCRIK QRIYEYNLQG HNIHWQDIGF AKRVEKYGDL SHRPKNNVKI IDLSMAHINN
IAVAAMLTKD DSDKCKLQVY DYEVKKRRRK LLYSMKNDYQ RCFLYDDFQS AIVICFKGDE
SKTIITEIDN FLRMEDGPLH RELLNYSRPQ CTNLLGIESR YRNIDNTLIF VIEFENDDGY
KSMIIISIDL ATADNLIYKS AWKPESPRKI YMDDNYLYLW QTEKHHDDDR YIDSIKCYKF
GGNKQQTQLL QMDLFDKKKG LICKVNINAN GNGRDPLIKY SPKYKEEDFF IAIWGEKDTN
LIVCLI
//
