ID B3SD12_TRIAD Unreviewed; 984 AA.
AC B3SD12;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 24-JAN-2024, entry version 79.
DE RecName: Full=DNA mismatch repair proteins mutS family domain-containing protein {ECO:0000259|PROSITE:PS00486};
GN ORFNames=TRIADDRAFT_33687 {ECO:0000313|EMBL:EDV19356.1};
OS Trichoplax adhaerens (Trichoplax reptans).
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV19356.1, ECO:0000313|Proteomes:UP000009022};
RN [1] {ECO:0000313|EMBL:EDV19356.1, ECO:0000313|Proteomes:UP000009022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV19356.1,
RC ECO:0000313|Proteomes:UP000009022};
RX PubMed=18719581; DOI=10.1038/nature07191;
RA Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA Rokhsar D.S.;
RT "The Trichoplax genome and the nature of placozoans.";
RL Nature 454:955-960(2008).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|RuleBase:RU003756}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|RuleBase:RU003756}.
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DR EMBL; DS985275; EDV19356.1; -; Genomic_DNA.
DR RefSeq; XP_002118131.1; XM_002118095.1.
DR AlphaFoldDB; B3SD12; -.
DR STRING; 10228.B3SD12; -.
DR EnsemblMetazoa; TriadT33687; TriadP33687; TriadG33687.
DR GeneID; 6759344; -.
DR KEGG; tad:TRIADDRAFT_33687; -.
DR CTD; 6759344; -.
DR eggNOG; KOG0217; Eukaryota.
DR HOGENOM; CLU_002472_1_3_1; -.
DR InParanoid; B3SD12; -.
DR OMA; TPMMAQY; -.
DR OrthoDB; 168255at2759; -.
DR PhylomeDB; B3SD12; -.
DR Proteomes; UP000009022; Unassembled WGS sequence.
DR GO; GO:0032301; C:MutSalpha complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IBA:GO_Central.
DR GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR CDD; cd03286; ABC_MSH6_euk; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF148; DNA MISMATCH REPAIR PROTEIN MSH6; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003756};
KW DNA repair {ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003756};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003756};
KW Reference proteome {ECO:0000313|Proteomes:UP000009022}.
FT DOMAIN 857..873
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EDV19356.1"
SQ SEQUENCE 984 AA; 111450 MW; 6A9797E3783514B7 CRC64;
GNDNYIHQGL KWMQDGFRKD SKGRLQSDPE YDSRTLWLPS GFLKEQTPLM RQWWQIKSEN
FDSVLCFKVG KFYEMYHMDA LIGISELGLI LMRVTQSSTA VAHCGFPEIA FSRYAETLAQ
RGYRVVRVEQ TETPQMMEER VKSSTRPTKF DKVVNREVCG RITKATRTFS VQNYEDPNSE
NAFLLAIIER ERDDLAVGHS LLGVCFLDTT IGKFHLGQFT DDRQCSRLRT LVTHFQPVQI
LYERGKVSSK LQHIFQHDLL SAMKDALAPG SEFWDSNNTL KILSEKSYFT KDGNEADDAS
LDTWPETLRN FVEGDGFGIT AKEDYDLTVS ALGASIWYLT KCFLDYDLMS LKNFEEYVPP
DAPSPDRLVA GNILKHKHMI LDAVTLINLD ILPTASDSGL RGTLLEKLDY CVTPTGKRLF
KHWLCTPLCD PVLINDRLDS VEDLMAMSSA VSDCLNTLRK IPDLEKLINK IHSLGSSRRS
NHPDNKAIFF EDTAYSKRKI LEFISVINGF KTLLQSIESL QTNRDKMKSR LLLQIITYTG
ENFSGIKGKF PQLLEYIQFF QKAFDHEQAK KDGKIIPKPG ADPEYDDAIQ SIAEIKQELE
HYLDSQKKRL NCRNIRYWGQ GRNRYQIEVP ESVLSRYTPN DYELRSRKKG FKRFWTGDIL
NLIESLTNAE ERRDAALKDA MRRIFLKFDE YYENWNVAIQ CVAVLDALCS LASYSSSIES
ESCRPKVAFA GNNDEPYVEI RNGRHPCISQ TFSGGDFIPN DTIIGIKDSN NCNETGNSVL
VTGPNMGGKS TLMRQVGLLA IMAQLGCYVP ATSCCLSPVD RLFTRLGASD RIMSGESTFF
VELSETTTIL RHATKHSLVL LDELGRGTAT YDGTAIAGAV VSHLAHEIKC RTLFSTHYHS
LVEDFVSDPN VRLGHMACMV ENEDDDDPSK ETITFLYKFV AGACPKSYGF NAARLAGLPD
NVIVKAKRKA KEFESSAKKL HLFR
//
