ID B3SEU3_TRIAD Unreviewed; 316 AA.
AC B3SEU3;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 24-JAN-2024, entry version 81.
DE RecName: Full=Myotubularin phosphatase domain-containing protein {ECO:0000259|PROSITE:PS51339};
GN ORFNames=TRIADDRAFT_34687 {ECO:0000313|EMBL:EDV18752.1};
OS Trichoplax adhaerens (Trichoplax reptans).
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV18752.1, ECO:0000313|Proteomes:UP000009022};
RN [1] {ECO:0000313|EMBL:EDV18752.1, ECO:0000313|Proteomes:UP000009022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV18752.1,
RC ECO:0000313|Proteomes:UP000009022};
RX PubMed=18719581; DOI=10.1038/nature07191;
RA Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA Rokhsar D.S.;
RT "The Trichoplax genome and the nature of placozoans.";
RL Nature 454:955-960(2008).
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR EMBL; DS985644; EDV18752.1; -; Genomic_DNA.
DR RefSeq; XP_002118762.1; XM_002118726.1.
DR AlphaFoldDB; B3SEU3; -.
DR STRING; 10228.B3SEU3; -.
DR EnsemblMetazoa; TriadT34687; TriadP34687; TriadG34687.
DR GeneID; 6759976; -.
DR KEGG; tad:TRIADDRAFT_34687; -.
DR CTD; 6759976; -.
DR eggNOG; KOG1089; Eukaryota.
DR HOGENOM; CLU_001839_3_2_1; -.
DR InParanoid; B3SEU3; -.
DR OMA; MRIENIH; -.
DR OrthoDB; 5474662at2759; -.
DR PhylomeDB; B3SEU3; -.
DR Proteomes; UP000009022; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0106018; F:phosphatidylinositol-3,5-bisphosphate phosphatase activity; IBA:GO_Central.
DR GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IBA:GO_Central.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF8; PHOSPHATIDYLINOSITOL-3-PHOSPHATE PHOSPHATASE; 1.
DR Pfam; PF06602; Myotub-related; 1.
DR Pfam; PF21098; PH-GRAM_MTMR6-like; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000009022}.
FT DOMAIN 73..316
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
FT ACT_SITE 285
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR630564-1"
FT BINDING 222..223
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR630564-2"
FT BINDING 285..291
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR630564-2"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EDV18752.1"
SQ SEQUENCE 316 AA; 36064 MW; 734C6AA73FA8BB14 CRC64;
HIATVEKQQI SIKGAPLKIV CKDFRVLNFV FYKEPDCQDV YVSLQNLTKP VNYAELHAFT
YEPPGSKWPR SDGWNIFEFE AEMARLEVPS DLWRKTDINK DYKLCPTYPE VLYVPATATE
ETLTGSASFR SRGRLPVLTY YHKYNKTALC RSSQPLTGMR GRSVDDEQLL QAVIQSNPKS
PVMYIVDTRP KINAMANKAA GKGYENLDNY PNVLYRFRGI QNIHVMRESL QKLSEVIENP
ALNAGEFFDS LDSSSWLKHI RSVIDTSRFI ALAMLMDNAS VLCHCSDGWD RTAQTCALAS
LFLDPYYRTI KGYQVQ
//