ID B4D8A5_9BACT Unreviewed; 408 AA.
AC B4D8A5;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Acetyl-CoA acetyltransferase {ECO:0000313|EMBL:EDY17298.1};
DE EC=2.3.1.16 {ECO:0000313|EMBL:EDY17298.1};
GN ORFNames=CfE428DRAFT_5145 {ECO:0000313|EMBL:EDY17298.1};
OS Chthoniobacter flavus Ellin428.
OC Bacteria; Verrucomicrobiota; Spartobacteria; Chthoniobacterales;
OC Chthoniobacteraceae; Chthoniobacter.
OX NCBI_TaxID=497964 {ECO:0000313|EMBL:EDY17298.1, ECO:0000313|Proteomes:UP000005824};
RN [1] {ECO:0000313|EMBL:EDY17298.1, ECO:0000313|Proteomes:UP000005824}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ellin428 {ECO:0000313|EMBL:EDY17298.1,
RC ECO:0000313|Proteomes:UP000005824};
RX PubMed=21460085; DOI=10.1128/JB.00295-11;
RA Kant R., van Passel M.W., Palva A., Lucas S., Lapidus A.,
RA Glavina Del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S.,
RA Larimer F.W., Land M.L., Hauser L., Sangwan P., de Vos W.M., Janssen P.H.,
RA Smidt H.;
RT "Genome sequence of Chthoniobacter flavus Ellin428, an aerobic
RT heterotrophic soil bacterium.";
RL J. Bacteriol. 193:2902-2903(2011).
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EDY17298.1}.
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DR EMBL; ABVL01000021; EDY17298.1; -; Genomic_DNA.
DR RefSeq; WP_006982466.1; NZ_ABVL01000021.1.
DR AlphaFoldDB; B4D8A5; -.
DR STRING; 497964.CfE428DRAFT_5145; -.
DR GeneID; 78184315; -.
DR eggNOG; COG0183; Bacteria.
DR InParanoid; B4D8A5; -.
DR Proteomes; UP000005824; Unassembled WGS sequence.
DR GO; GO:0003988; F:acetyl-CoA C-acyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020610; Thiolase_AS.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR18919:SF107; 3-KETOACYL-COA THIOLASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR18919; ACETYL-COA C-ACYLTRANSFERASE; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00737; THIOLASE_2; 1.
DR PROSITE; PS00099; THIOLASE_3; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW ECO:0000313|EMBL:EDY17298.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005824};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:EDY17298.1}.
FT DOMAIN 6..276
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 284..406
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 89
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 364
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 394
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 408 AA; 42944 MW; 77B238FD4C45907C CRC64;
MNERMVIVDG VRTPFCKMGT DLATFPADDL GRIAVNALLT RTGLDPALVD EVIFGCVSQP
AEAANIARVI ALRAGIPQSV PAATVHRNCA SGFESFTTAY ERMCAGRGSV YIVGGAESMS
HVPMLFQETT AQKFTDLARS KTTAQKVSAL ASFRVGDFEP RAGLKLGLTD PVCGLNMGET
AELLAKENEI TREQQDAFAL HSHEKAIAGE AKLSEEMCPV YVNGKPLLKD NGPRANQSMA
ILGGLKPVFE KYGTVTAGNS SQITDGAVAL LVMTESRARE LGYTPLGVLV GYAYAGTDPA
RMGLGPVAAI EKLGKSNSLT LADADLIEIN EAFAAQVLAV LQRLKPEVPP DKLNVNGGAI
ALGHPVGATG ARLVLTSLKE LARRNAKRAL VSLCVGGGQG GAIWLERI
//
