ID   B4DCK3_9BACT            Unreviewed;       657 AA.
AC   B4DCK3;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   24-JAN-2024, entry version 47.
DE   SubName: Full=Squalene-hopene cyclase {ECO:0000313|EMBL:EDY15838.1};
GN   ORFNames=CfE428DRAFT_6644 {ECO:0000313|EMBL:EDY15838.1};
OS   Chthoniobacter flavus Ellin428.
OC   Bacteria; Verrucomicrobiota; Spartobacteria; Chthoniobacterales;
OC   Chthoniobacteraceae; Chthoniobacter.
OX   NCBI_TaxID=497964 {ECO:0000313|EMBL:EDY15838.1, ECO:0000313|Proteomes:UP000005824};
RN   [1] {ECO:0000313|EMBL:EDY15838.1, ECO:0000313|Proteomes:UP000005824}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Ellin428 {ECO:0000313|EMBL:EDY15838.1,
RC   ECO:0000313|Proteomes:UP000005824};
RX   PubMed=21460085; DOI=10.1128/JB.00295-11;
RA   Kant R., van Passel M.W., Palva A., Lucas S., Lapidus A.,
RA   Glavina Del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S.,
RA   Larimer F.W., Land M.L., Hauser L., Sangwan P., de Vos W.M., Janssen P.H.,
RA   Smidt H.;
RT   "Genome sequence of Chthoniobacter flavus Ellin428, an aerobic
RT   heterotrophic soil bacterium.";
RL   J. Bacteriol. 193:2902-2903(2011).
CC   -!- PATHWAY: Secondary metabolite biosynthesis; hopanoid biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004999}.
CC   -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC       {ECO:0000256|ARBA:ARBA00009755}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EDY15838.1}.
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DR   EMBL; ABVL01000052; EDY15838.1; -; Genomic_DNA.
DR   RefSeq; WP_006983961.1; NZ_ABVL01000052.1.
DR   AlphaFoldDB; B4DCK3; -.
DR   STRING; 497964.CfE428DRAFT_6644; -.
DR   GeneID; 78186936; -.
DR   eggNOG; COG1657; Bacteria.
DR   InParanoid; B4DCK3; -.
DR   UniPathway; UPA00337; -.
DR   Proteomes; UP000005824; Unassembled WGS sequence.
DR   GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR   GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR   GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR   CDD; cd02892; SQCY_1; 1.
DR   Gene3D; 1.50.10.20; -; 2.
DR   InterPro; IPR006400; Hopene-cyclase.
DR   InterPro; IPR032696; SQ_cyclase_C.
DR   InterPro; IPR032697; SQ_cyclase_N.
DR   InterPro; IPR018333; Squalene_cyclase.
DR   InterPro; IPR002365; Terpene_synthase_CS.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   NCBIfam; TIGR01507; hopene_cyclase; 1.
DR   NCBIfam; TIGR01787; squalene_cyclas; 1.
DR   PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR   PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR   Pfam; PF13243; SQHop_cyclase_C; 1.
DR   Pfam; PF13249; SQHop_cyclase_N; 1.
DR   SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
DR   PROSITE; PS01074; TERPENE_SYNTHASES; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005824};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          19..308
FT                   /note="Squalene cyclase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13249"
FT   DOMAIN          318..645
FT                   /note="Squalene cyclase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13243"
SQ   SEQUENCE   657 AA;  75275 MW;  92A496DAB782DAC0 CRC64;
     MIFTDTPTGS TQNRLDVAIR RAQQNLLRLQ HNEGYWCGEL FVDSTLCSDY VLFMHWADEI
     DPVMEEKCVA HIRRRQLEDG GWNIYEGGPS DVNATVKAYF ALKLAGHAPT QPWMQEARAC
     ILRLGGIPKM NTYAKLYLAL LGQFPWRYLP TVPVEIMFMP RWFFFDIYEV SSWSRAMLMP
     LAILNHYKPT KHLPADKQLH ELYPIGSEES DLGLGMQKPR FSWPNFFLFC DRLIKIMHSL
     PWKPWKRAAL ARAEAWMTQR MGEGSDGLAA IFPAMLNSMI ALRTLRYSRE HPLYVKAKND
     FAGLFVDDPQ DFRIQPCLSP VWDTAINLVA LLESGLDPHD PKIEAAVNWL KEKEVRINGD
     WYVKNHHVPP SGWAFEFNNV YYPDTDDTMM VLAALARAGA HEESAPVETK AMFERALKWL
     LSFQCRDGGW AAFDKDVTQG WLEDVPFADH NAILDPTCSD LTGRVLELLG LIDYDRNCTP
     VRRALKFLRD TQEDDGSWYG RWGVNYIYGT WQVLRGLRSI GEDMRQQWIV RARDWLESCQ
     NEDGGWGETC ASYDDPTLKG KGPSTASQTA WALMGLIAAA DPTEPGAFDR KSIRQGVDYL
     LSTQVADGSW VEPEVTGTGF PRVFYLRYDM YRNNFPLMAL ATYRKAREGK LPVRQRE
//