GenomeNet

Database: UniProt
Entry: B4DKC9
LinkDB: B4DKC9
Original site: B4DKC9 
ID   B4DKC9_HUMAN            Unreviewed;       491 AA.
AC   B4DKC9;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   07-OCT-2020, entry version 35.
DE   RecName: Full=Metavinculin {ECO:0000256|ARBA:ARBA00015999};
DE   AltName: Full=Vinculin {ECO:0000256|ARBA:ARBA00014125};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG59141.1};
RN   [1] {ECO:0000313|EMBL:BAG59141.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Thalamus {ECO:0000313|EMBL:BAG59141.1};
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA   Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA   Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA   Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project focused on splicing variants.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell junction, adherens junction
CC       {ECO:0000256|ARBA:ARBA00004536}. Cell membrane, sarcolemma
CC       {ECO:0000256|ARBA:ARBA00004278}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004278}; Cytoplasmic side
CC       {ECO:0000256|ARBA:ARBA00004278}. Cytoplasm, cytoskeleton
CC       {ECO:0000256|ARBA:ARBA00004245}.
CC   -!- SIMILARITY: Belongs to the vinculin/alpha-catenin family.
CC       {ECO:0000256|ARBA:ARBA00008376}.
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DR   EMBL; AK296509; BAG59141.1; -; mRNA.
DR   PeptideAtlas; B4DKC9; -.
DR   GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell.
DR   GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR   InterPro; IPR036723; Alpha-catenin/vinculin-like_sf.
DR   InterPro; IPR017997; Vinculin.
DR   InterPro; IPR006077; Vinculin/catenin.
DR   PANTHER; PTHR46180; PTHR46180; 2.
DR   Pfam; PF01044; Vinculin; 2.
DR   SUPFAM; SSF47220; SSF47220; 4.
PE   2: Evidence at transcript level;
KW   Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490}.
FT   REGION          282..312
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          449..469
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        284..298
FT                   /note="Pro-rich"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   491 AA;  54278 MW;  185E38B6B9BCC636 CRC64;
     MPVFHTRTIE SILEPVAQQI SHLVIMHEEG EVDGKAIPDL TAPVAAVQAA VSNLVLVGKE
     TVQTTEDQIL KRDMPPAFIK VENACTKLVQ AAQMLQSDPY SVPARILLRN PGNQAAYEHF
     ETMKNQWIDN VEKMTGLVDE AIDTKSLLDA SEEAIKKDLD KCKVAMANIQ PQMLVAGATS
     IARRANRILL VAKREVENSE DPKFREAVKA ASDELSKTIS PMVMDAKAVA GNISDPGLQK
     SFLDSGYRIL GAVAKVREAF QPQEPDFPPP PPDLEQLRLT DELAPPKPPL PEGEVPPPRP
     PPPEEKDEEF PEQKAGEVIN QPMMMAARQL HDEARKWSSK GNDIIAAAKR MALLMAEMSR
     LVRGGSGTKR ALIQCAKDIA KASDEVTRLA KEVAKQCTDK RIRTNLLQVC ERIPTISTQL
     KILSTVKATM LGRTNISDEE SEQATEMLVH NAQNLMQSVK ETVREAEAAS IKIRTDAGFT
     LRWVRKTPWY Q
//
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