ID B4DY31_HUMAN Unreviewed; 420 AA.
AC B4DY31;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 103.
DE SubName: Full=cDNA FLJ51386 {ECO:0000313|EMBL:BAG63593.1};
DE SubName: Full=von Willebrand factor C and EGF domains {ECO:0000313|Ensembl:ENSP00000442570.1};
GN Name=VWCE {ECO:0000313|Ensembl:ENSP00000442570.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG63593.1};
RN [1] {ECO:0000313|Ensembl:ENSP00000442570.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [2] {ECO:0000313|EMBL:BAG63593.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Testis {ECO:0000313|EMBL:BAG63593.1};
RA Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA Sugano S., Nomura N., Isogai T.;
RT "NEDO human cDNA sequencing project focused on splicing variants.";
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSP00000442570.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AP003037; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK302241; BAG63593.1; -; mRNA.
DR Antibodypedia; 52915; 115 antibodies from 17 providers.
DR Ensembl; ENST00000535710.1; ENSP00000442570.1; ENSG00000167992.14.
DR UCSC; uc058byo.1; human.
DR HGNC; HGNC:26487; VWCE.
DR VEuPathDB; HostDB:ENSG00000167992; -.
DR GeneTree; ENSGT00940000161089; -.
DR HOGENOM; CLU_653738_0_0_1; -.
DR ChiTaRS; VWCE; human.
DR Proteomes; UP000005640; Chromosome 11.
DR Bgee; ENSG00000167992; Expressed in right uterine tube and 119 other cell types or tissues.
DR Gene3D; 6.20.200.20; -; 3.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR47333; VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR47333:SF1; VON WILLEBRAND FACTOR C AND EGF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00093; VWC; 2.
DR SMART; SM00214; VWC; 3.
DR SUPFAM; SSF57603; FnI-like domain; 3.
DR PROSITE; PS01208; VWFC_1; 2.
DR PROSITE; PS50184; VWFC_2; 3.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:B4DY31};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 31..91
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 92..150
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 150..208
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT REGION 277..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 368..420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..337
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 383..402
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 420 AA; 43749 MW; 5DE2E85356359081 CRC64;
MPCPELACPR EEWRLGPGQC CFTCQEPTPS TGCSLDDNGV EFPIGQIWSP GDPCELCICQ
ADGSVSCKRT DCVDSCPHPI RIPGQCCPDC SAGCTYTGRI FYNNETFPSV LDPCLSCICL
LGSVACSPVD CPITCTYPFH PDGECCPVCR DCNYEGRKVA NGQVFTLDDE PCTRCTCQLG
EVSCEKVPCQ RACADPALLP GDCCSSCPDS LSPLEEKQGL SPHGNVAFSK AGRSLHGDTE
APVNCSSCPG PPTASPSRPV LHLLQLLLRT NLMKTQTLPT SPAGAHGPHS LALGLTATFP
GEPGASPRLS PGPSTPPGAP TLPLASPGAP QPPPVTPERS FSASGAQIVS RWPPLPGTLL
TEASALSMMD PSPSKTPITL LGPRVLSPTT SRLSTALAAT THPGPQQPPV GASRGEESTM
//
