ID B4DZ85_HUMAN Unreviewed; 448 AA.
AC B4DZ85;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE SubName: Full=Nuclear receptor coactivator 4 {ECO:0000313|EMBL:BAG63997.1, ECO:0000313|Ensembl:ENSP00000462352.1};
GN Name=NCOA4 {ECO:0000313|Ensembl:ENSP00000462352.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|EMBL:BAG63997.1};
RN [1] {ECO:0000313|Ensembl:ENSP00000462352.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [2] {ECO:0000313|EMBL:BAG63997.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Testis {ECO:0000313|EMBL:BAG63997.1};
RA Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K., Sugiyama A.,
RA Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y., Kumagai A., Oishi Y.,
RA Yamamoto S., Ono Y., Komori Y., Yamazaki M., Kisu Y., Nishikawa T.,
RA Sugano S., Nomura N., Isogai T.;
RT "NEDO human cDNA sequencing project focused on splicing variants.";
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSP00000462352.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL450342; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK302794; BAG63997.1; -; mRNA.
DR IntAct; B4DZ85; 2.
DR ProteomicsDB; 5581; -.
DR Antibodypedia; 72715; 485 antibodies from 34 providers.
DR Ensembl; ENST00000580070.5; ENSP00000462352.1; ENSG00000266412.6.
DR UCSC; uc010qhf.3; human.
DR HGNC; HGNC:7671; NCOA4.
DR VEuPathDB; HostDB:ENSG00000266412; -.
DR GeneTree; ENSGT00390000008403; -.
DR ChiTaRS; NCOA4; human.
DR Proteomes; UP000005640; Chromosome 10.
DR Bgee; ENSG00000266412; Expressed in jejunal mucosa and 215 other cell types or tissues.
DR GO; GO:0003713; F:transcription coactivator activity; IEA:InterPro.
DR GO; GO:0006879; P:intracellular iron ion homeostasis; IEA:InterPro.
DR InterPro; IPR022174; ARA70.
DR InterPro; IPR039947; NCoA-4.
DR PANTHER; PTHR17085; NUCLEAR RECEPTOR COACTIVATOR 4; 1.
DR PANTHER; PTHR17085:SF5; NUCLEAR RECEPTOR COACTIVATOR 4; 1.
DR Pfam; PF12489; ARA70; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:B4DZ85,
KW ECO:0007829|MaxQB:B4DZ85}; Receptor {ECO:0000313|EMBL:BAG63997.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 33..161
FT /note="Nuclear coactivator"
FT /evidence="ECO:0000259|Pfam:PF12489"
FT REGION 335..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 448 AA; 50712 MW; B0B1F3FD79570242 CRC64;
MAHASSANIG PFLEKRGCIS MPEQKSASGI VAVPFSEWLL GSKPASGYQA PYIPSTDPQD
WLTQKQTLEN SQTSSRACNF FNNVGGNLKG LENWLLKSEK SSYQKCNSHS TTSSFSIEME
KVGDQELPDQ DEMDLSDWLV TPQESHKLRK PENGSRETSE KFKLLFQSYN VNDWLVKTDS
CTNCQGNQPK GVEIENLGNL KCLNDHLEAK KPLSTPSMVT EDWLVQNHQD PCKVEEVCRA
NEPCTSFAEC VCDENCEKEA LYKWLLKKEG KDKNGMPVEP KPEPEKHKDS LNMWLCPRKE
VIEQTKAPKA MTPSRIADSF QVIKNSPLSE WLIRPPYKEG SPKEVPGTED RAGKQKFKSP
MNTSWCSFNT ADWVLPGKKM GNLSQLSSGE DKWLLRKKAQ EVLLNSPLQE EHNFPPDHYG
LPAVCDLFAC MQLKVDKEKW LYRTPLQM
//
