ID B4EKF6_BURCJ Unreviewed; 337 AA.
AC B4EKF6;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Low-specificity L-threonine aldolase {ECO:0000313|EMBL:CAR56535.1};
DE EC=4.1.2.5 {ECO:0000313|EMBL:CAR56535.1};
GN Name=ltaE {ECO:0000313|EMBL:CAR56535.1};
GN ORFNames=BCAM2671 {ECO:0000313|EMBL:CAR56535.1};
OS Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 /
OS NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315)).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX NCBI_TaxID=216591 {ECO:0000313|EMBL:CAR56535.1, ECO:0000313|Proteomes:UP000001035};
RN [1] {ECO:0000313|EMBL:CAR56535.1, ECO:0000313|Proteomes:UP000001035}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 /
RC CF5610 {ECO:0000313|Proteomes:UP000001035};
RX PubMed=18931103; DOI=10.1128/JB.01230-08;
RA Holden M.T., Seth-Smith H.M., Crossman L.C., Sebaihia M., Bentley S.D.,
RA Cerdeno-Tarraga A.M., Thomson N.R., Bason N., Quail M.A., Sharp S.,
RA Cherevach I., Churcher C., Goodhead I., Hauser H., Holroyd N., Mungall K.,
RA Scott P., Walker D., White B., Rose H., Iversen P., Mil-Homens D.,
RA Rocha E.P., Fialho A.M., Baldwin A., Dowson C., Barrell B.G., Govan J.R.,
RA Vandamme P., Hart C.A., Mahenthiralingam E., Parkhill J.;
RT "The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of
RT cystic fibrosis patients.";
RL J. Bacteriol. 191:261-277(2009).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- SIMILARITY: Belongs to the threonine aldolase family.
CC {ECO:0000256|ARBA:ARBA00006966}.
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DR EMBL; AM747721; CAR56535.1; -; Genomic_DNA.
DR RefSeq; WP_006490800.1; NC_011001.1.
DR AlphaFoldDB; B4EKF6; -.
DR KEGG; bcj:BCAM2671; -.
DR eggNOG; COG2008; Bacteria.
DR HOGENOM; CLU_029381_0_3_4; -.
DR BioCyc; BCEN216591:G1G1V-6784-MONOMER; -.
DR Proteomes; UP000001035; Chromosome 2.
DR GO; GO:0004793; F:threonine aldolase activity; IEA:UniProtKB-EC.
DR GO; GO:0006520; P:amino acid metabolic process; IEA:InterPro.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR001597; ArAA_b-elim_lyase/Thr_aldolase.
DR InterPro; IPR023603; Low_specificity_L-TA-like.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR NCBIfam; NF041359; GntG_guanitoxin; 1.
DR PANTHER; PTHR48097:SF9; L-THREONINE ALDOLASE; 1.
DR PANTHER; PTHR48097; L-THREONINE ALDOLASE-RELATED; 1.
DR Pfam; PF01212; Beta_elim_lyase; 1.
DR PIRSF; PIRSF017617; Thr_aldolase; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000313|EMBL:CAR56535.1}.
FT DOMAIN 3..283
FT /note="Aromatic amino acid beta-eliminating lyase/threonine
FT aldolase"
FT /evidence="ECO:0000259|Pfam:PF01212"
FT MOD_RES 197
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR017617-1"
SQ SEQUENCE 337 AA; 35813 MW; 063B2332192F5C5F CRC64;
MIDLRSDTVT RPSQAMLAAM TAAETGDDVW GDDPTVLRLQ AVTAERAGKE AGLFFPSGTQ
SNLAALMSHC ERGDEYIVGQ LAHTYKYEGG GAAVLGSIQP QPIENAPDGT LPLAKIAAAI
KPLDNHFART RLLALENTIG GQVLPEGYVQ EAVAFARSRG LSTHLDGARV CNAAVASGRP
IAALCAPFDT VSICFSKGLG APVGSVLVGS RALIERAQRW RKVLGGGMRQ SGILAAACLY
ALDHNVERLA DDHANAAHLA DGLARIDSVK VLSHATNMVF AQFPEADCAP LEAWLKERGI
LTQMLYASRF VTHCDVSRAD IDTFLGAVGE YFSQRRA
//
