ID B4EUL8_PROMH Unreviewed; 654 AA.
AC B4EUL8;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE SubName: Full=Metalloprotease {ECO:0000313|EMBL:CAR40763.1};
GN OrderedLocusNames=PMI0283 {ECO:0000313|EMBL:CAR40763.1};
OS Proteus mirabilis (strain HI4320).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Morganellaceae; Proteus.
OX NCBI_TaxID=529507 {ECO:0000313|EMBL:CAR40763.1, ECO:0000313|Proteomes:UP000008319};
RN [1] {ECO:0000313|EMBL:CAR40763.1, ECO:0000313|Proteomes:UP000008319}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HI4320 {ECO:0000313|EMBL:CAR40763.1,
RC ECO:0000313|Proteomes:UP000008319};
RX PubMed=18375554; DOI=10.1128/JB.01981-07;
RA Pearson M.M., Sebaihia M., Churcher C., Quail M.A., Seshasayee A.S.,
RA Luscombe N.M., Abdellah Z., Arrosmith C., Atkin B., Chillingworth T.,
RA Hauser H., Jagels K., Moule S., Mungall K., Norbertczak H.,
RA Rabbinowitsch E., Walker D., Whithead S., Thomson N.R., Rather P.N.,
RA Parkhill J., Mobley H.L.;
RT "Complete genome sequence of uropathogenic Proteus mirabilis, a master of
RT both adherence and motility.";
RL J. Bacteriol. 190:4027-4037(2008).
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR EMBL; AM942759; CAR40763.1; -; Genomic_DNA.
DR RefSeq; WP_012367537.1; NC_010554.1.
DR AlphaFoldDB; B4EUL8; -.
DR EnsemblBacteria; CAR40763; CAR40763; PMI0283.
DR GeneID; 6801189; -.
DR KEGG; pmr:PMI0283; -.
DR PATRIC; fig|529507.6.peg.272; -.
DR eggNOG; COG2931; Bacteria.
DR HOGENOM; CLU_025059_1_1_6; -.
DR Proteomes; UP000008319; Chromosome.
DR GO; GO:0031012; C:extracellular matrix; IEA:InterPro.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 2.150.10.10; Serralysin-like metalloprotease, C-terminal; 2.
DR InterPro; IPR001343; Hemolysn_Ca-bd.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR001818; Pept_M10_metallopeptidase.
DR InterPro; IPR013858; Peptidase_M10B_C.
DR InterPro; IPR003995; RTX_toxin_determinant-A.
DR InterPro; IPR011049; Serralysin-like_metalloprot_C.
DR PANTHER; PTHR38340; S-LAYER PROTEIN; 1.
DR PANTHER; PTHR38340:SF1; S-LAYER PROTEIN; 1.
DR Pfam; PF00353; HemolysinCabind; 2.
DR Pfam; PF00413; Peptidase_M10; 1.
DR Pfam; PF08548; Peptidase_M10_C; 1.
DR PRINTS; PR00313; CABNDNGRPT.
DR PRINTS; PR01488; RTXTOXINA.
DR SUPFAM; SSF51120; beta-Roll; 2.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00023049, ECO:0000313|EMBL:CAR40763.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW ECO:0000313|EMBL:CAR40763.1};
KW Protease {ECO:0000256|ARBA:ARBA00023049, ECO:0000313|EMBL:CAR40763.1};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Toxin {ECO:0000256|ARBA:ARBA00022656};
KW Virulence {ECO:0000256|ARBA:ARBA00023026}.
FT DOMAIN 139..302
FT /note="Peptidase M10 metallopeptidase"
FT /evidence="ECO:0000259|Pfam:PF00413"
FT DOMAIN 355..645
FT /note="Peptidase M10 serralysin C-terminal"
FT /evidence="ECO:0000259|Pfam:PF08548"
FT COILED 74..116
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 654 AA; 73837 MW; 4CF394010BEFB9D2 CRC64;
MKLIKNTKKP TFFYLLDGVI STGAISGWPK NSIDGTTHLT YTFPNYSERS ENIRNKHPIT
ESQKKEALKE LAEYYKLDYE IEKMKKELKA IEDKDSEGFQ KRIEEINQDI KSKSERSGQI
IKNIPLYFLA TPMTIFPHQQ EVITEILQLA SDFADLTFTR VPIQKNANLK FGYFNHFYKD
STTFFMTRGN GGFAQYPNYN GTPIKEIGPN EDYDIPGTIF INLATHEFYK WENGDNIDKY
IENEANPGDL YNYHDNNQVA IIKSTDVLLN ETMKSKHKLG SYEYLCFIHE LGHALGLMHI
NVYLKNIKND VILTYKYSVM AYQFADIKDA DFAGLYPMTF MLVDILLLQY LYGPNMTTRL
ENNTYGFHSN TGRAAYSLNS IEDKLVSCIW DAGGIDTLDF SLYTVNQVIN LNEGCFSDIG
GLRSNISIAY KTIIENAIGG KGDDTLIGNP FDNNLIGGDG NDLFYGGDGN DLFYGGSGND
VIYGELGNDV LYGDDGDDML IDYYGANMLD GGKGNDRICV ASTDRGLPGR NIILGGEGDD
EIYLGTGTHR ITGGQGNDTF NFFCYESVES NSFIWDFEKN KDKITLITRD YRKIDITKMK
KVDKLSGSKN EFSLNYNKPA NKTIIDVSTS SNDDNTIVHI EIVGIFNHDE LFAI
//
