ID B4F021_PROMH Unreviewed; 499 AA.
AC B4F021;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 80.
DE RecName: Full=Phosphate transporter {ECO:0000256|RuleBase:RU363058};
GN Name=pitA {ECO:0000313|EMBL:CAR45930.1};
GN OrderedLocusNames=PMI3011 {ECO:0000313|EMBL:CAR45930.1};
OS Proteus mirabilis (strain HI4320).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Morganellaceae; Proteus.
OX NCBI_TaxID=529507 {ECO:0000313|EMBL:CAR45930.1, ECO:0000313|Proteomes:UP000008319};
RN [1] {ECO:0000313|EMBL:CAR45930.1, ECO:0000313|Proteomes:UP000008319}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HI4320 {ECO:0000313|EMBL:CAR45930.1,
RC ECO:0000313|Proteomes:UP000008319};
RX PubMed=18375554; DOI=10.1128/JB.01981-07;
RA Pearson M.M., Sebaihia M., Churcher C., Quail M.A., Seshasayee A.S.,
RA Luscombe N.M., Abdellah Z., Arrosmith C., Atkin B., Chillingworth T.,
RA Hauser H., Jagels K., Moule S., Mungall K., Norbertczak H.,
RA Rabbinowitsch E., Walker D., Whithead S., Thomson N.R., Rather P.N.,
RA Parkhill J., Mobley H.L.;
RT "Complete genome sequence of uropathogenic Proteus mirabilis, a master of
RT both adherence and motility.";
RL J. Bacteriol. 190:4027-4037(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+)(in) + phosphate(in) = H(+)(out) + phosphate(out);
CC Xref=Rhea:RHEA:29939, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474;
CC Evidence={ECO:0000256|ARBA:ARBA00034281};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU363058}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU363058}.
CC -!- SIMILARITY: Belongs to the inorganic phosphate transporter (PiT) (TC
CC 2.A.20) family. Pit subfamily. {ECO:0000256|ARBA:ARBA00005342}.
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DR EMBL; AM942759; CAR45930.1; -; Genomic_DNA.
DR RefSeq; WP_004246659.1; NC_010554.1.
DR AlphaFoldDB; B4F021; -.
DR EnsemblBacteria; CAR45930; CAR45930; PMI3011.
DR GeneID; 6803373; -.
DR KEGG; pmr:PMI3011; -.
DR eggNOG; COG0306; Bacteria.
DR HOGENOM; CLU_015355_4_0_6; -.
DR Proteomes; UP000008319; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005315; F:inorganic phosphate transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006817; P:phosphate ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR047818; Phos_trans_PitA_PitB.
DR InterPro; IPR001204; Phos_transporter.
DR NCBIfam; NF033774; phos_trans_PitA; 1.
DR PANTHER; PTHR11101:SF65; LOW-AFFINITY INORGANIC PHOSPHATE TRANSPORTER 1-RELATED; 1.
DR PANTHER; PTHR11101; PHOSPHATE TRANSPORTER; 1.
DR Pfam; PF01384; PHO4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363058};
KW Phosphate transport {ECO:0000256|RuleBase:RU363058};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU363058};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU363058};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU363058}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 52..76
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 96..116
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 155..177
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 208..227
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 233..252
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 378..399
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
FT TRANSMEM 471..497
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363058"
SQ SEQUENCE 499 AA; 53602 MW; 69AD89AA5205A6F4 CRC64;
MLHLFTDLEF HTGLMLVLAL IFVLFYEAIN GFHDTANAVA TVIYTRAMRA QFAVVMAGVF
NFLGVLLGGL SVAYAIVHLL PTDLLLNVSS AHGLAMVFSL LLAAIIWNLG TWYFGIPASS
SHTLIGAIIG IGLTNAIVTD SSIVDALNIP KMISIFLSLI LSPIIGLVIA GAMIFLLRRY
WSGTKKRRRI HLTPAEREKK DGKRKPPFWT RTALILSAVG VSFSHGANDG QKGIGLIMLV
LIGVAPAGFV VNMNASGYDI TKTHDAVVHL QQYYEKHQPA LQHAIENTPV VSAQADPNDT
DFHCNSARTP IVLNQTEQML SGISSYDELS ADQRAQMRRL LMCIADTATE VAKLPETSAQ
DARFLKTLSR DLLNTVEYAP IWIIISVALA LSIGTMVGWK RVAVTIGEKI GKKGMTYAQG
VSAQVTAAVS IGVASYTGMP VSTTQVLSSA VAGTMIVDGG GVQTKTVKNI ALAWILTLPV
SIALSGVLYW ISLSLLVNS
//
