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Database: UniProt
Entry: B4F6U4
LinkDB: B4F6U4
Original site: B4F6U4 
ID   PRD10_XENTR             Reviewed;        1173 AA.
AC   B4F6U4;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   16-JAN-2019, entry version 53.
DE   RecName: Full=PR domain zinc finger protein 10;
DE            EC=2.1.1.-;
DE   AltName: Full=PR domain-containing protein 10;
GN   Name=prdm10;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC   Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- DOMAIN: The SET domain is degenerated, suggesting that it has lost
CC       methyltransferase activity.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU00190}.
DR   EMBL; BC168013; AAI68013.1; -; mRNA.
DR   RefSeq; NP_001135541.1; NM_001142069.1.
DR   UniGene; Str.58567; -.
DR   UniGene; Str.78031; -.
DR   SMR; B4F6U4; -.
DR   STRING; 8364.ENSXETP00000062917; -.
DR   PaxDb; B4F6U4; -.
DR   GeneID; 100216084; -.
DR   KEGG; xtr:100216084; -.
DR   CTD; 56980; -.
DR   Xenbase; XB-GENE-985864; prdm10.
DR   eggNOG; KOG1721; Eukaryota.
DR   eggNOG; COG5048; LUCA.
DR   HOVERGEN; HBG053664; -.
DR   InParanoid; B4F6U4; -.
DR   OrthoDB; 1318335at2759; -.
DR   Proteomes; UP000008143; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000979; F:RNA polymerase II core promoter sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 3.
DR   SMART; SM00355; ZnF_C2H2; 10.
DR   SUPFAM; SSF57667; SSF57667; 3.
DR   PROSITE; PS50280; SET; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10.
PE   2: Evidence at transcript level;
KW   Complete proteome; DNA-binding; Metal-binding; Methyltransferase;
KW   Nucleus; Reference proteome; Repeat; S-adenosyl-L-methionine;
KW   Transcription; Transcription regulation; Transferase; Zinc;
KW   Zinc-finger.
FT   CHAIN         1   1173       PR domain zinc finger protein 10.
FT                                /FTId=PRO_0000363966.
FT   DOMAIN      248    366       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
FT   ZN_FING     395    417       C2H2-type 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     559    581       C2H2-type 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     589    611       C2H2-type 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     617    639       C2H2-type 4. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     645    668       C2H2-type 5. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     673    695       C2H2-type 6. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     701    724       C2H2-type 7. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     756    779       C2H2-type 8. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     801    824       C2H2-type 9. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   ZN_FING     863    886       C2H2-type 10. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00042}.
FT   COMPBIAS    174    184       Poly-Asp.
FT   COMPBIAS    943   1058       Gln-rich.
FT   COMPBIAS   1157   1160       Poly-Thr.
SQ   SEQUENCE   1173 AA;  132140 MW;  03B08ECC73CD1BE3 CRC64;
     MDTKEGSPHV WPTSVEHQSN TAQVHFVPDG GSVAQIVYSD DQDRAQQQVV YTADASSFTS
     VDASEHTLVY IHPVDGSQTL FTDQPQVAYV QQDATTQQVT VLLPAAQSMN AANLAVLSGV
     SESAQTMSLD PVSQINRASL TVHDHRLPPM EGADSSTTIN SLPSPNAHSD GKEDDDDDDD
     DDDDEEEEDD DGEDSDLDDW EAEPPRPFDP NDLWCEECNN AHPSVCPKHG ALHPIPNRPV
     LTRARASLPL VLYIDRFLGG VYSKRRIPKR TQFGPLEGPL VKKTELKDSY IHLKVALNSP
     VDSEGAFQED LWFELSEESL CNWMMFVRPA QNHLEQNLVA YQYGQHIYFT TIKNIEPKQE
     LKVWYAASYA EFVNEKIHDI TQEERKVLRE QEKNWPCYEC NRRFMSSEQL QQHLNSHDEK
     LDFISRTKPR GRTRTRRKFG PGRRPGRPPK FLRFDISSEN REKIDLGTQD LLQFHNKGPH
     FEDCGHSTLN GLEQSELTLG TSTQGTPNQQ QATQLLPPNE ISTPVATTSI LTAEDMRRAK
     RIRNAALQHL FIRKSFRPFK CLQCGKAFRE KEKLDQHLRF HGRDGNYPLT CDICNKGFIS
     TSSLENHMKF HLDQKTYSCI FCPESFDRLD LLKDHVVVHI IDGCFSCPTC KKRFTDFIQV
     KKHVRSFHSE KIYQCTECDK AFCRPDKLRL HMLRHSDRKD FLCSTCGKQF KRKDKLREHM
     QRMHNPEREA KKADRTGRAK AFKPRLASTD YESFMFKCRV CMMGFRRRGM LVNHLSKRHP
     EMKIDEVPEL TLPIIKPNRD YYCQYCEKVY KSASKRKAHI LKNHPGAELP PSIRKLRPAG
     PGEPDPMLST HTQLTGTIAT PPVCCPHCSK QYSSKTKMVQ HIRKKHPEFS LLPISVQAPV
     LGTAPAVLTA DGTSGETVVT TDLLTQAMTE LSQTLTTEYR TPQGDFQRIQ YIPVSQTTGG
     MQQPQHIQLQ VVQVAQAQSP NQSQHSTVDM GQLHESQGYM QHAIQVQHIQ VAEPTSGTQS
     TPQVGGQALS PSSQEAEEVN PSQLQTPASQ AQANSAVQHA YLPSGWNSFR GYPSEIQMMA
     LPQGQYVIAE AAVGTPVTPV SSGQVKAVTQ THYVISEGQG VLDMKKSSSL AEEATPNPDH
     MEQPASNSSQ TTQYIITTTT NMNGSSEVHI SKP
//
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