ID B4F6V2_XENTR Unreviewed; 894 AA.
AC B4F6V2; F6UY60;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 99.
DE SubName: Full=Nuclear factor of activated T-cells, cytoplasmic 3 {ECO:0000313|RefSeq:NP_001135546.1};
DE SubName: Full=Nuclear factor of-activated T cells 3 {ECO:0000313|Ensembl:ENSXETP00000012789};
DE SubName: Full=Solute carrier family 2, facilitated glucose transporter member 10 {ECO:0000313|Ensembl:ENSXETP00000007515};
GN Name=nfatc3 {ECO:0000313|Ensembl:ENSXETP00000012789,
GN ECO:0000313|RefSeq:NP_001135546.1,
GN ECO:0000313|Xenbase:XB-GENE-493918};
GN Synonyms=nf-at {ECO:0000313|RefSeq:NP_001135546.1}, nfat4
GN {ECO:0000313|RefSeq:NP_001135546.1}, nfatx
GN {ECO:0000313|RefSeq:NP_001135546.1}, slc2a10
GN {ECO:0000313|Ensembl:ENSXETP00000007515};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:AAI68023.1};
RN [1] {ECO:0000313|RefSeq:NP_001135546.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAI68023.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testes {ECO:0000313|EMBL:AAI68023.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUL-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSXETP00000007515}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000007515};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [4] {ECO:0000313|Ensembl:ENSXETP00000012789}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [5] {ECO:0000313|RefSeq:NP_001135546.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BC168023; AAI68023.1; -; mRNA.
DR RefSeq; NP_001135546.1; NM_001142074.1.
DR RefSeq; XP_017948436.1; XM_018092947.1.
DR STRING; 8364.ENSXETP00000007515; -.
DR PaxDb; 8364-ENSXETP00000012789; -.
DR Ensembl; ENSXETT00000007515; ENSXETP00000007515; ENSXETG00000003471.
DR Ensembl; ENSXETT00000012789; ENSXETP00000012789; ENSXETG00000005812.
DR Ensembl; ENSXETT00000120224; ENSXETP00000108019; ENSXETG00000005812.
DR GeneID; 100216091; -.
DR KEGG; xtr:100216091; -.
DR AGR; Xenbase:XB-GENE-493918; -.
DR CTD; 4775; -.
DR Xenbase; XB-GENE-493918; nfatc3.
DR Xenbase; XB-GENE-950490; slc2a10.
DR eggNOG; ENOG502QWQ4; Eukaryota.
DR HOGENOM; CLU_010185_0_0_1; -.
DR OMA; QGHKSYE; -.
DR OrthoDB; 5405363at2759; -.
DR TreeFam; TF326480; -.
DR Proteomes; UP000008143; Chromosome 4.
DR Bgee; ENSXETG00000003471; Expressed in ovary and 12 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043229; C:intracellular organelle; IEA:UniProt.
DR GO; GO:0043227; C:membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR CDD; cd01178; IPT_NFAT; 1.
DR CDD; cd07881; RHD-n_NFAT; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR008366; NFAT.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR12533; NFAT; 1.
DR PANTHER; PTHR12533:SF6; NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR Pfam; PF00554; RHD_DNA_bind; 1.
DR PRINTS; PR01789; NUCFACTORATC.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS50254; REL_2; 1.
PE 2: Evidence at transcript level;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143}.
FT DOMAIN 401..582
FT /note="RHD"
FT /evidence="ECO:0000259|PROSITE:PS50254"
FT REGION 225..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 280..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 225..249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 894 AA; 98976 MW; 76B03628DE2AE161 CRC64;
MSAAHCGWED LDFRAIFGEE TLENRESVDI APDDCASFFI FSRDQANSSV SQPVCIPHNE
HQIHSSTHSS ASCLQDYRTY DSSSEIQDYT CSSSFGPKSF ECPSIQITSI SPSCHQDIGT
FENAENNRPE RDYMDRPLRD HLCLHLEPSF REPSLSPSPG SSISSRSWIS DASSCESLSH
IYDDLDSELN EAAARFTLGS PLTSPSGSPR EHPVEKTWHV CSVSPSSRQS PCHSPRNSIT
DENWLSPRPS SKPPSRPTSP CGKRRHSSAD IFYSGLVSPH YSPATSPGPS PRGSITEDSW
LNASPHPVPS LSLYQCWQET AIPLKTRKTS EDHSARLAGK TELNTEDLAC LSPTVDMPTD
ESACSQHPVI QDSSTDQFLS VPSHFTWNKH KSGHTPVFRT SSLPPLDWAL PSRYGQYELK
VDVQPKTHHR AHYETEGSRG AVKAVTGNHP IVKLTGYTEK PLNLQMFIGT ADDRYVRPHA
FYQVHRITGK TVATASQEIV ITNTKVLEIP LLPENNMTAS IDCAGILKLR NSDIELRKGE
TDIGRKNTRV RLVFRVHIPQ TSGKVLSLQA ASVPIECSQR SAQELPQVEK YSINSCSVNG
GLELVITGSN FMPDSKVIFL EKGQDGCTHW EAEGKTVFKK CQMNNIVVEI PAYHNKTIAA
DVQVQFYVCN GKRKRSQSQR FNYTPVLLKQ ENLEDGDLQE ATAVSLAKGR GISDLRMIHT
SLLFQDQRSI CKTLKSSSPP GVECPTQPTF TSSLKHEIPQ ISKIQEPCTS SSPSTADPET
MENYPVSIYS SPQKQSMPYQ CFSPDIPVLP SSSLTAMPHT GQPSSHTHDC RLRGISLSPT
ITHPRQNSAS SHPTDMSLGI KAELVDHDIN FQTKDLEDIT LDDVAEIIRR DMSH
//
