ID CLU_DROPE Reviewed; 1435 AA.
AC B4GAM1;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Protein clueless {ECO:0000255|HAMAP-Rule:MF_03013};
DE AltName: Full=Clustered mitochondria protein homolog {ECO:0000255|HAMAP-Rule:MF_03013};
GN Name=clu {ECO:0000255|HAMAP-Rule:MF_03013}; ORFNames=GL11405;
OS Drosophila persimilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7234;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MSH-3 / Tucson 14011-0111.49;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC distribution of mitochondria. {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03013}.
CC -!- SIMILARITY: Belongs to the CLU family. {ECO:0000255|HAMAP-
CC Rule:MF_03013}.
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DR EMBL; CH479181; EDW31973.1; -; Genomic_DNA.
DR RefSeq; XP_002016083.1; XM_002016047.1.
DR AlphaFoldDB; B4GAM1; -.
DR SMR; B4GAM1; -.
DR STRING; 7234.B4GAM1; -.
DR EnsemblMetazoa; FBtr0177020; FBpp0175512; FBgn0149014.
DR GeneID; 6590515; -.
DR KEGG; dpe:6590515; -.
DR eggNOG; KOG1839; Eukaryota.
DR HOGENOM; CLU_003256_1_0_1; -.
DR OMA; HPVWDKD; -.
DR OrthoDB; 927222at2759; -.
DR PhylomeDB; B4GAM1; -.
DR Proteomes; UP000008744; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:EnsemblMetazoa.
DR GO; GO:0031315; C:extrinsic component of mitochondrial outer membrane; IEA:EnsemblMetazoa.
DR GO; GO:0005794; C:Golgi apparatus; IEA:EnsemblMetazoa.
DR GO; GO:0072686; C:mitotic spindle; IEA:EnsemblMetazoa.
DR GO; GO:0098799; C:outer mitochondrial membrane protein complex; IEA:EnsemblMetazoa.
DR GO; GO:0003729; F:mRNA binding; IEA:EnsemblMetazoa.
DR GO; GO:0043022; F:ribosome binding; IEA:EnsemblMetazoa.
DR GO; GO:0055059; P:asymmetric neuroblast division; IEA:EnsemblMetazoa.
DR GO; GO:0051646; P:mitochondrion localization; IEA:EnsemblMetazoa.
DR GO; GO:0007005; P:mitochondrion organization; IEA:UniProtKB-UniRule.
DR CDD; cd15466; CLU-central; 1.
DR Gene3D; 3.30.2280.10; Hypothetical protein (hspc210); 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR HAMAP; MF_03013; CLU; 1.
DR InterPro; IPR033646; CLU-central.
DR InterPro; IPR025697; CLU_dom.
DR InterPro; IPR028275; CLU_N.
DR InterPro; IPR027523; CLU_prot.
DR InterPro; IPR007967; GSKIP_dom.
DR InterPro; IPR023231; GSKIP_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR12601:SF6; CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG; 1.
DR PANTHER; PTHR12601; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3; 1.
DR Pfam; PF13236; CLU; 1.
DR Pfam; PF15044; CLU_N; 1.
DR Pfam; PF12807; eIF3_p135; 1.
DR Pfam; PF05303; GSKIP_dom; 1.
DR Pfam; PF13374; TPR_10; 1.
DR Pfam; PF13424; TPR_12; 1.
DR SUPFAM; SSF103107; Hypothetical protein c14orf129, hspc210; 1.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS51823; CLU; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Phosphoprotein; Reference proteome; Repeat; TPR repeat.
FT CHAIN 1..1435
FT /note="Protein clueless"
FT /id="PRO_0000366384"
FT DOMAIN 420..662
FT /note="Clu"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01167"
FT REPEAT 1096..1129
FT /note="TPR 1"
FT REPEAT 1222..1255
FT /note="TPR 2"
FT REPEAT 1257..1290
FT /note="TPR 3"
FT REGION 1..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 719..762
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 952..998
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1407..1435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..95
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 721..762
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 976..998
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 266
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 1435 AA; 160351 MW; 8095C6B00A9D349E CRC64;
MALEMDSKNS NSAVTGDAAA ATTKTNKAKE NNNLAGSKKN QSQNLVNGNG TAADGPATKK
KGKKNRNKSP PVSTDEAALS NGHVEEKKPE GDGDADADAN ANVVAVKDEK AEGGDEADAA
ELDTEDIDLD ALHDAGIHVN ISCPGSELLT VQLSSMELVQ EIHQLLMDRE ESCHRTCFSL
QLDNVTLDNF AELKTIEQLE SGSTIKVVEE PYTMREARIH VRHVRDLLKN LDPADAYNGI
ECTSLTYLNT ITQGDLLDKK KTRPDSVDCT PPDYVTPGVF EPPLLPLHPN FKNAKGPQAL
KVLTTSAWNP PPGPRKLHGD LMYLYVITME EKRYHISACS RGFFINQSTD DTFNPKPDNP
SYLSHSLIDL LSHISPSFRR AFQAIQKRRT LRHAFERVAT PYQVYQWAAP NLEHTVDAIR
AEDAFSSKLG YEEHIPGQTR DWNEELQTTR ELPRKTLPER LLRERAIFKV HGDFVTAATR
GAMAVIDGNV LAINPGEDSK MQMFIWNNIF FSLGFDVRDH YKELGGDYAA YVAPRYDLHG
VRVYNAVDVE GLYTLGTVVI DYRGYRVTAQ SIIPGILERE QEQSVVYGSI DFGKTVLSHP
KYLELLRQAG KHLKILPHSV YNERDEPVEL CSSVECKGII GNDGRHYILD LLRTFPPDVN
FLKLQEVKLS TELVEMGFPI EHRHKLCCLR QELLEAFVED RYVNFIRIAA VHLQQLNAKK
PEETQSEEKK QLPAIEEAEK ENKENLNVNE TPNEKEKDTP VETKNAEAMV NAIREAQSNV
ATSNEIQAAE VVKQACAAVG SMKEKEFDFR FNPDVFSPGI RHVDGEEGTS GSVAKQKLLV
QDAAEFLVVK QIPAFVKEHL SHSSPPIDGQ NLTESLHSHG INVRYLGKVI KTLGQMPRMD
YLYRIAVMEL IVRATKHIYY TYMQSTDPMH LSVAISHFLN CLLTNGPINP VVSNDEMHKK
RGGNGGKHNK HKSSKGGKGQ QQPAINQNGG STTSSSSSAN AYDWTLVTPR SLWQQIRKES
KAYWDWDLDC DSMDSAMNKF GIMRICLLRA FCLKVGIQVL LREYNFDSKH KPTFGDDDIV
NVFPVVKHIS PRASDAYNFY TTGQAKIQQG LFKEGYELIS EALNLLNNVF GAMHQENGSC
LRMLARLSYL LGDAQDALAI QQRAVIMSER VNGIDNPSTI LEYTHLSLYS FANGHVGMSL
KLLYRARYLL VLTCGEDHPE VALIDSNISL ILHALGEYEL SLRFIEHALK LNLKYFGNKA
MHVAVSYHLM ARTQSCMGDF RSALNNEKET YSIYKSQLGE KHEKTRDSAE CLRLLTQQAV
LLQRKMNDIY SNGKLTSDLP PIHITPPSMG SVLEMLNTIN GILFVQISQR DIVKVRSEIE
KRMKANTDVN EAIKSMVAAA NNNGESEVLA PQDNNKEQAA TAQQLTNGDK VAVSS
//
