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Database: UniProt
Entry: B4GD21_DROPE
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Original site: B4GD21_DROPE 
ID   B4GD21_DROPE            Unreviewed;      1219 AA.
AC   B4GD21;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   28-MAR-2018, entry version 63.
DE   SubName: Full=GL11199 {ECO:0000313|EMBL:EDW31559.1};
GN   Name=Dper\GL11199 {ECO:0000313|EMBL:EDW31559.1};
GN   ORFNames=Dper_GL11199 {ECO:0000313|EMBL:EDW31559.1}, GL11199
GN   {ECO:0000313|FlyBase:FBgn0148809};
OS   Drosophila persimilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7234 {ECO:0000313|Proteomes:UP000008744};
RN   [1] {ECO:0000313|EMBL:EDW31559.1, ECO:0000313|Proteomes:UP000008744}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MSH-3 / Tucson 14011-0111.49
RC   {ECO:0000313|Proteomes:UP000008744};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 Genomes Consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
RA   Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
RA   Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
RA   Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
RA   Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
RA   Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
RA   Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
RA   Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
RA   Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
RA   Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
RA   Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
RA   Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
RA   Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
RA   Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
RA   Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
RA   Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
RA   Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
RA   Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
RA   Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
RA   Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
RA   Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
RA   Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
RA   Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
RA   McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
RA   Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
RA   Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
RA   Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
RA   Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
RA   Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
RA   Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
RA   Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
RA   Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
RA   Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
RA   Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
RA   Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
RA   Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
RA   Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
RA   Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
RA   Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
RA   Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
RA   Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
RA   Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
RA   An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
RA   Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
RA   Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
RA   Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
RA   Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
RA   DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
RA   Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
RA   Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
RA   LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
RA   Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
RA   Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
RA   Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
RA   Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
RA   Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
RA   Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
RA   Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
RA   Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
RA   Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
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DR   EMBL; CH479181; EDW31559.1; -; Genomic_DNA.
DR   RefSeq; XP_002015669.1; XM_002015633.1.
DR   EnsemblMetazoa; FBtr0176814; FBpp0175306; FBgn0148809.
DR   GeneID; 6590079; -.
DR   KEGG; dpe:Dper_GL11199; -.
DR   FlyBase; FBgn0148809; Dper\GL11199.
DR   KO; K21862; -.
DR   OMA; LQIAVEX; -.
DR   OrthoDB; EOG091G01WJ; -.
DR   PhylomeDB; B4GD21; -.
DR   Proteomes; UP000008744; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR   Gene3D; 1.20.120.350; -; 2.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR027359; Volt_channel_dom_sf.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 3.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008744};
KW   Membrane {ECO:0000256|SAAS:SAAS00085096, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008744};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00084820,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00084701,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    133    151       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    158    176       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    196    216       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    251    271       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    379    405       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    631    655       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    675    706       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    764    789       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1009   1035       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      131    410       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      566    796       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      953   1044       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1086   1138       GPHH. {ECO:0000259|Pfam:PF16905}.
FT   COILED      814    834       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1219 AA;  140389 MW;  8F10907805B06DDF CRC64;
     MHANSPNQAK TVHSQPNLSV AKHQVVAYTQ RSQVKHENRH IQLVREYGFH PRTKASVEDG
     DVLPRKFEPF PEDMYGKPLE EIDTFIYEET FCVVSKRFRK NYIHRFTGTK SLFLFHPWSP
     ARRVCVYIAT NQFFDYCVMA TILFNCIFLA MTETVEEAEY IFLAIYSIEM VIKIIAKGFL
     LNKYTYLRNP WNWLDFVVIT SGYATIGMEV GNLAGLRTFR VLRALKTVSI MPGLKTIINA
     LLHSFRQLAE VMTLTIFCLM VFALFALQVY MGELRNKCVR HVPSEWSNVS HLDWHMWVND
     TDNWLFDDEE MPVLCGNLTG ARHCPFGYMC ICVGENPNHG YTNFDNFMWS MLTTFQLITL
     DYWENVYNMV LATCGPMSVI FFTVVVFFGS FYLINLMLAV VALSYEEEAE ITNEERKKDL
     LDHRDDSTFS FDPSVLNVKK LNKNNKKRID SRKGVLLASG VNRESSQDDS GVVDDHEEQD
     PANELGHVST VELALSPREV RLIKCNGNIA RIKNHNVYAL HQEFSSEVVV IDDLPDRNCD
     RCVHCCADYE SWLQFQNCLY KVVRDPLFEL AITLCIVLNT AFLAMEHHGM SESFRNALDV
     GNKVFTSIFT FECIVKLMAL SKDFFLCGWN IFDLLIVTAS LLDIIFELVD GLSVLRGLRL
     LRVLKLAQSW TTMKVLLSII ISTIGALGNL TLILVIVIYI FAVIGMQLFS KDYTAEKFDP
     DPVPRWNFND FFHSFMMIFR ILCGEWIEPL WDCMRAEEEQ GASTCFAIFL PTLVMGNFMV
     LNLFLALLLN SFNSEELKSK KEEVGEESKL ARSIERVRDL IRKKRQERKD RKERKFAEKF
     QQIVLEAQAQ AHAQSQGQAQ GGMEMDKSNL LAETKFHRLS YQPSAFTRLT EKPWHCLVSY
     VDDLTVGGRR NSQGAYNDPM TFPSYGQAKP PKVPDDCFPQ KCYDTEVNDK WDCIEQNYTW
     INSKITFDHV GMGYLALLQV ATFEGWMEVM ADAVDARGVD LQPQREANLY AYIYFVIFIV
     CGSFFTLNLF IGVIIDNFNM LKKKVRDCDL CTDFSQHAYH GHRALRSTAC GLLYTGSEQR
     LLHHGLWSGY DPHATQFIHF SQLSDFIASL DPPLGISKPN NVALVSFNLP ISKGNKIHCL
     DILHALVKHV LGHVEETDNF KQLQEQMDVK FKKQFPTRKE LEIVSSTRIW KRQEKAAKTI
     QTGWKDYLRY YILHHQSTT
//
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