ID B4GD85_DROPE Unreviewed; 1241 AA.
AC B4GD85;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE SubName: Full=GL10366 {ECO:0000313|EMBL:EDW32580.1};
GN Name=Dper\GL10366 {ECO:0000313|EMBL:EDW32580.1};
GN ORFNames=Dper_GL10366 {ECO:0000313|EMBL:EDW32580.1};
OS Drosophila persimilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7234 {ECO:0000313|Proteomes:UP000008744};
RN [1] {ECO:0000313|EMBL:EDW32580.1, ECO:0000313|Proteomes:UP000008744}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MSH-3 / Tucson 14011-0111.49
RC {ECO:0000313|Proteomes:UP000008744};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; CH479181; EDW32580.1; -; Genomic_DNA.
DR RefSeq; XP_002016690.1; XM_002016654.1.
DR AlphaFoldDB; B4GD85; -.
DR STRING; 7234.B4GD85; -.
DR EnsemblMetazoa; FBtr0175981; FBpp0174473; FBgn0147976.
DR eggNOG; KOG4641; Eukaryota.
DR HOGENOM; CLU_004280_0_0_1; -.
DR OMA; CCEYEQC; -.
DR PhylomeDB; B4GD85; -.
DR Proteomes; UP000008744; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:EnsemblMetazoa.
DR GO; GO:0019731; P:antibacterial humoral response; IEA:EnsemblMetazoa.
DR GO; GO:0003401; P:axis elongation; IEA:EnsemblMetazoa.
DR GO; GO:0007155; P:cell adhesion; IEA:EnsemblMetazoa.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0060026; P:convergent extension; IEA:EnsemblMetazoa.
DR GO; GO:0030703; P:eggshell formation; IEA:EnsemblMetazoa.
DR GO; GO:0007297; P:follicle cell of egg chamber migration; IEA:EnsemblMetazoa.
DR GO; GO:0007165; P:signal transduction; IEA:EnsemblMetazoa.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 6.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24369; ANTIGEN BSP, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR24369:SF210; CHAOPTIN-RELATED; 1.
DR Pfam; PF13855; LRR_8; 4.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00364; LRR_BAC; 5.
DR SMART; SM00365; LRR_SD22; 5.
DR SMART; SM00369; LRR_TYP; 15.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52047; RNI-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 7.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008744};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1241
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002803427"
FT TRANSMEM 844..866
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 892..1029
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 1078..1098
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1138..1160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1186..1241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1241 AA; 139245 MW; 2456D47377F61369 CRC64;
MLAFCLLLLL TAAAVPVRSA HAQQCAWEFV RTTMDIKCNV RALDAAAPLD LQVAETANRL
ELQCSQDLLH ASELSAGLFG RLQKLEELQV DACKLQRIPA NAFEGLLSLK RLSLQTHNAM
WGPGKTLDLH AQSFHGLRDL SELHLADNNG LLHRLEQLLV LDLSGNQLTS HHVDNNTFAG
LIRLIVLNLS NNALTRIGAK TFKELYFLQI LDMRNNSIGH VEEGAFLPLY NLHTLNLAEN
RLHTLDNKIF NGLYVLTKLT LNNNLISIVE TQAFRNCSDL KELDLSSNQL MEVPEAVQDL
SMLKTLDLGE NQISDFKNNT FRNLNQLTGL RLIDNRIGNI TVGMFQDLPR LSVLNLAKNR
IQNIERGAFD KNTEIEAIRL DKNFLTDING IFATLASLLW LNLSENHLVW FDYAFIPSNL
KWLDIHGNYI EALGNYYKLQ EEIRVTTLDA SHNRITEIGA MSVPNSIELL FINNNIIGQI
QANTFVDKTR LARVDLYANV LSKISLNALR VAPVSAEKPV PEFYLGGNPF ECDCSMEWLQ
RINNLTTRQH PRVVDLANIE CLMPHSRNAP LRPLSSLAST DFVCKYDSHC PPTCHCCEYE
QCECEVICPN NCSCFHDATW STNIVDCGKQ DLVSLPARIP QDVSDLYLDG NNIPVLEAGQ
LAGKRNLRAL YLNSSNLMTL QNGSLSQLSN LRVLHLENNK LTALEGTEFQ PLNLLRELYL
HNNMLTHISN GSFEPLVSLK VLRLDNNRLS SLPNLQYRNS LQGLTLGRNA WSCRCQQLRE
LAQFVSDNAM VVRDSADIYC IDAGIKRELE LLGNVAGGPD CSELLDASAS NISSSQDIAG
GYRLPLLAAV LVLIFLVVVL IIVFVFRESV RMWLFAHYGV RVCEPRFEDA GKLYDAIILH
SEKDYEFVCR NIAAELEHGR PPFRLCIQQR DLPPQASHLQ LVEGARASRK IILVLTRNLL
ATEWNRVEFR NAFHEALRGL AQKLVIIEET SVSSEAEDVA ELSPYLKSVP SNRLLTCDRY
FWEKLRYAIP IELSPRGNNY TLDHHERFKQ PVSPGMIFRQ APPPPAYYCT EDMEANYSSA
TTATPSPRPT RPGGPARIVD SMPMPMRPPS EHIYHSIESE YSAYDQHEAL SMIPTGLMHH
HQHQQQQLAR HHQQQQQQRL LQPQFRAVGA AMPVPQQATA PVHLRSGSGL SQASTSTQST
AQASTSAAAA QQQQQQQQQQ QQQQTAANGE TANKNGQAFL V
//
