ID B4GKY9_DROPE Unreviewed; 1355 AA.
AC B4GKY9;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=GL26191 {ECO:0000313|EMBL:EDW37305.1};
GN Name=Dper\GL26191 {ECO:0000313|EMBL:EDW37305.1};
GN ORFNames=Dper_GL26191 {ECO:0000313|EMBL:EDW37305.1};
OS Drosophila persimilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7234 {ECO:0000313|Proteomes:UP000008744};
RN [1] {ECO:0000313|EMBL:EDW37305.1, ECO:0000313|Proteomes:UP000008744}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MSH-3 / Tucson 14011-0111.49
RC {ECO:0000313|Proteomes:UP000008744};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
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DR EMBL; CH479184; EDW37305.1; -; Genomic_DNA.
DR RefSeq; XP_002019109.1; XM_002019073.1.
DR STRING; 7234.B4GKY9; -.
DR ESTHER; drope-b4gky9; Neuroligin.
DR EnsemblMetazoa; FBtr0191806; FBpp0190298; FBgn0163773.
DR GeneID; 6593731; -.
DR KEGG; dpe:6593731; -.
DR eggNOG; KOG1516; Eukaryota.
DR HOGENOM; CLU_006586_5_0_1; -.
DR OMA; CCDCLHG; -.
DR OrthoDB; 4386at2759; -.
DR PhylomeDB; B4GKY9; -.
DR Proteomes; UP000008744; Unassembled WGS sequence.
DR GO; GO:0031594; C:neuromuscular junction; IEA:EnsemblMetazoa.
DR GO; GO:0045211; C:postsynaptic membrane; IEA:EnsemblMetazoa.
DR GO; GO:0042043; F:neurexin family protein binding; IEA:EnsemblMetazoa.
DR GO; GO:0007628; P:adult walking behavior; IEA:EnsemblMetazoa.
DR GO; GO:0002121; P:inter-male aggressive behavior; IEA:EnsemblMetazoa.
DR GO; GO:0008345; P:larval locomotory behavior; IEA:EnsemblMetazoa.
DR GO; GO:0048790; P:maintenance of presynaptic active zone structure; IEA:EnsemblMetazoa.
DR GO; GO:0045433; P:male courtship behavior, veined wing generated song production; IEA:EnsemblMetazoa.
DR GO; GO:0050805; P:negative regulation of synaptic transmission; IEA:EnsemblMetazoa.
DR GO; GO:0007274; P:neuromuscular synaptic transmission; IEA:EnsemblMetazoa.
DR GO; GO:2000331; P:regulation of terminal button organization; IEA:EnsemblMetazoa.
DR GO; GO:0035176; P:social behavior; IEA:EnsemblMetazoa.
DR GO; GO:0060074; P:synapse maturation; IEA:EnsemblMetazoa.
DR GO; GO:0051124; P:synaptic assembly at neuromuscular junction; IEA:EnsemblMetazoa.
DR GO; GO:0048499; P:synaptic vesicle membrane organization; IEA:EnsemblMetazoa.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR002018; CarbesteraseB.
DR InterPro; IPR019819; Carboxylesterase_B_CS.
DR PANTHER; PTHR43903:SF30; FI21425P1; 1.
DR PANTHER; PTHR43903; NEUROLIGIN; 1.
DR Pfam; PF00135; COesterase; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR PROSITE; PS00941; CARBOXYLESTERASE_B_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008744};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1064..1090
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 277..798
FT /note="Carboxylesterase type B"
FT /evidence="ECO:0000259|Pfam:PF00135"
FT REGION 17..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 175..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 788..807
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1287..1355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..53
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 178..208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 788..806
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1309..1349
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1355 AA; 148813 MW; 10DA01D5466DC0F9 CRC64;
MDVLHVLDVV DVAQAASLHQ PQPQSQSQSQ TPSKSPTGSG HGQLILTATR TKTRRTTRTS
RTRTRSKLRQ TKIIQSRFLH IYGYFFFGSL MSYIKTICAS MVQQMAAEAD KETEVEVAVA
LPAAKAKRKP VTETETATGM GVGMGTGTDA RIVATGICII RLITLKRFLE ISTTDKHNQK
HQQQQQQQQQ HQHQPWQSAA SAMSPTSVEA SAVGGGGGEA DPVQNRRHSH PHTPSHSHIR
HPQACWRHQL TPGILLMLLL LSSLWPDCCD CLHGGGNTVK TKYGLLRGIV VRSTPLVEAF
LGIPYASAPV GSLRFMPPIT PSTWKTVRNA DRFSPVCPQN VPIPPNGPEA LLEVPRARLA
QLRRLLPLLK NQSEDCLYLN IYVPYETRRS KRNVDADVES AETTATKLST VVFIHGESFD
WNSGNPYDGS ELAAHGNVIV VTINFRLGIF GFLKTGGKES AQGNFGLMDL VAGLHWLKEN
LPAFGGDPQS ITLLGYGTGA VLANILVVSP VSSDLIQRTV LVSGSALSPW AIQKNPLFVK
RRVAEQTGCH GDMLYDDLAP CLRTKSVAEL LAVKVDHPRF LVGFAPFVDG TVISPVANPL
GSTTLPLGSA IVSTSGIEYA NFPKRDLIFC LSSVESYLDL SAQDLEFGFN ETRRDRILRT
FVRNNFHYHL NEIFAVLKNE YTDWEKAIRN PLSSRDATLQ FLSDGHTASP LIKLGYMHSL
RGGRTYFLHF KHKTVEEEYP QRTGSVRGED VPFWLGLPIS PLFPHNYTTQ ERQIGRLMLR
YLSNFAKTGN PNQSTEKTAL GNSEDATLHQ QKKRSAAVVP NPHLSDAMTL AVLYNQRRSN
AMHEKRSYIR RRLRSNNDGA FTQLGLASER DVGSYEGDDL PFWDAYDVVN QLYVELGNKA
NIQSHYRGHK LSMWLNLIPQ LHRHFNINDQ SMRHHQFQDD MNNRDLYEGV VRPQLQTKPA
EDDNIIIIQK SRTTTTTPPP PKTPSANVTQ ALNPMISGTA TTTECGIDGA MSVSELTTTQ
APKDNRTGGH TRVETQKDLA TASTGIIGNL ELLRRLSGKQ FQSYTTALIA TVAVGCFLLI
LNVLIFAGIY HQREKRARDA KTKEELQESD TSKSSSMLKL NALIGGGGGG PGGCGSGDHA
DAYSLSGTVV DSKGGVGVVF GEYSCYDEKT KQLKEEKLIV ELPPSSSVSV SGQTSLMMDS
WGACSTSTLD LLKTKPGIGM ADSHLEMVSY NALPTLMEST SALSSKRGSF VENSLQFNSP
QQFDYAVQSS DQMSFKAIEE AVKAAAIQDS EIMRDDDIPE PPPPPRSFLA AQQQQQQQQQ
QQQGILRQTG TAGSATTGPG SSGSKKRVHI QEISV
//
