ID B4GQT1_DROPE Unreviewed; 2094 AA.
AC B4GQT1;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE SubName: Full=GL16615 {ECO:0000313|EMBL:EDW39953.1};
GN Name=Dper\GL16615 {ECO:0000313|EMBL:EDW39953.1};
GN ORFNames=Dper_GL16615 {ECO:0000313|EMBL:EDW39953.1};
OS Drosophila persimilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7234 {ECO:0000313|Proteomes:UP000008744};
RN [1] {ECO:0000313|EMBL:EDW39953.1, ECO:0000313|Proteomes:UP000008744}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MSH-3 / Tucson 14011-0111.49
RC {ECO:0000313|Proteomes:UP000008744};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR EMBL; CH479187; EDW39953.1; -; Genomic_DNA.
DR RefSeq; XP_002020960.1; XM_002020924.1.
DR SMR; B4GQT1; -.
DR STRING; 7234.B4GQT1; -.
DR EnsemblMetazoa; FBtr0182230; FBpp0180722; FBgn0154219.
DR eggNOG; KOG1997; Eukaryota.
DR eggNOG; KOG4260; Eukaryota.
DR HOGENOM; CLU_000624_0_0_1; -.
DR OMA; FPHQFND; -.
DR PhylomeDB; B4GQT1; -.
DR Proteomes; UP000008744; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0035011; P:melanotic encapsulation of foreign target; IEA:EnsemblMetazoa.
DR GO; GO:0006909; P:phagocytosis; IEA:EnsemblMetazoa.
DR GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:EnsemblMetazoa.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd08696; C2_Dock-C; 1.
DR CDD; cd00064; FU; 2.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR037808; C2_Dock-C.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF76; LD20667P; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR SMART; SM00261; FU; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01248; EGF_LAM_1; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000008744}.
FT DOMAIN 593..762
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1612..2094
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 418..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 434..468
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2094 AA; 237122 MW; 461FBE92E18CFB2A CRC64;
MSNAQRSFVQ KVSKQPAADV RKNVCNYHIQ SKSADTSLCS SALSPTDPLD YEEFLVQHMN
IVNRDPLKLI LDFPQGDVTV KTIPRKIRTI DHITPNEEIT DLPQHVQECV NCYTRPWKVV
EYAQRHYSSS CYIREHIDRG TISPSAYQQE FEIDKDFASF DETFTYKSES CTPSSRQSIA
SLASVSSCTD TLTPRGSWAS FDLRRSVNDP LIPNLLNNVP PEQIDQTNEV RRQQDRQVAL
FSLYPESEAE EERIERRLLA EIPMEHMGHR IQVKCLQLRL ELEVEPIFAS MALYDAKERQ
KLSENFYFDM NSDGLKRMLS SHVQCADIST QSHSAIFEIS YPSNDLFLVI RLEKVLQGDI
NNSVEPYLKE DKDKYREKVK SNAADYCERL GKYRMPFAWT GIYLTNVFNG DSFEHKDVGG
GERDSAGSGN VCGGLGTAPS SNSLDRKSST SSFDQLRRKA NDMSGTLTRR GSLERKEKRR
SWSPDDFANV VENFRPITIS VPSFFKQEAD KMKDEDLYKI LPELKRPSSV MKKYKCIPGS
IKLEISPCVE EVKNSLTPEL AKINPQSGEN IRPIKEILEF PQSAIYNPHY SYRNLLFVSP
KELNFSSRAG SARNIAVRVQ LMAGETSKDA VNAIFGKSSC PKFSSEAFTA VNYHNKCPSF
YDEIKIALPA SIKQHHHLLF TIYHVSCQKK PQDLQPSVET PIGYTWLPLL EDGKLKVGEF
NLPVMVETPP ENYSFIPPNV HLPGIKWLDN HRAVFAINVE AVTAIHTLDS FLDRFFLLCE
YVDTRNIPSH IGEGNMEAEL KKCLLDIEHA NREPLVRHLP LVLDKLIELL VTTHKIGGQT
MSLGSTVFEV LCLVSSLLSI LSDDLIVDQY GRQSLFSTYV QFQCKIPHPL LSKQRFTCRR
SNTEDLQLSN SYSLYDNVST SGRSLDRKDP ASNMLHSIVG RDVQERLLHE ELALHWVVAS
GKAAELAMAN SWFLFELIVK SMIEHLHNSN TLNAPRKNRF PHQYNDDLST LVHLVTTKVV
GYHSNEPKLA QSLNASLSFF IFDVLSIMDR GFVFGLIKTY TKVLISKNAS IPDLMNYKID
FLRIVCSHEH FVALNLPFGT SYTMISAPCS PTPSTTSSNS QTSCGSLERA VQADLSQEFL
QQHFLVGLVL SDLASVMKVP NPQLHGKAIR CIRNLMTSHD LDTRYSETEA RARVASLYIP
LLFIVMDSIP QLHQHGIDHD RLHQIGQLED YQGPQQTIAA ATISPEVAYA ISGSRPYYMS
EQVKNKSPLS SENTRHLLVC FLWVLKNLER NILYRWLLGL TPHRVHQMLQ VVNVCLKTFE
YTGQKYIPTL KRTNTQSFRK NASTDVKEKL EECIRGTNSA RYDLINRRKD RNSTEKFRWR
KDQMPYRSPY TDSVGKNEHD LELSHFIEGS LATEITLVLL DTLEILVHVA ANIHHNLLGT
LLKVLLHALS RNQSTLALQN LFASQRALIF KFPNLLFDEE TDICADLCLI LLKHCGSLLP
GIRSQAAASL YLLMRQNFEI GNNFARVKMQ VTMSLSSLVG TSTVFSEQSL RRALKTVLVY
AESDSDLQDT SFPEQVQDLL FNLHMILSDT VKMKEYQEDP EMLLDLMNRI AKGYQNNPDL
RLTWLENMAK KHRERANHTE AAMCYVHAAA LVSEYLSMLE SQTHLPVGAV SFQRISPNTL
MESAVSDDVL SPGEDGICLG NHFTETGLKA LLEEASNSFQ VAGMYEAMNE VYKILIPICE
ANRDFLKLGK VHGKLQEAFN RISQLQGKRV FGTYFRVGFY GSKFGDLDQQ EFIYKEPTLT
KLPEIFSRLQ NFYTERFGPD SVHIIKDSNT VDVNSLDAEK AYIQITYVEP YFETYEMRHR
ETYFERNFNI SKCKGAGTRK GNGKCLCDAG YAGSNCKECA LQYYESFRDE KKLLCTQCHA
ACGDGGCTGA GPKSCRKCKD GWHMDSETGC VDINECLYQQ RPTACRPQQF CVNNEGSFSC
LECDRSCNGC DGDGPDMCKQ CADGFVLKDG KCQDQSAEER DSYVNFTRLL TYFGMCVATC
VIFQSSTHIG WGCVVGAAVA VYIAASEYWL NSPQAGHKPE IDTKQLEELI MKSL
//
