ID B4H179_DROPE Unreviewed; 2787 AA.
AC B4H179;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE SubName: Full=GL22532 {ECO:0000313|EMBL:EDW30056.1};
GN Name=Dper\GL22532 {ECO:0000313|EMBL:EDW30056.1};
GN ORFNames=Dper_GL22532 {ECO:0000313|EMBL:EDW30056.1};
OS Drosophila persimilis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7234 {ECO:0000313|Proteomes:UP000008744};
RN [1] {ECO:0000313|EMBL:EDW30056.1, ECO:0000313|Proteomes:UP000008744}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MSH-3 / Tucson 14011-0111.49
RC {ECO:0000313|Proteomes:UP000008744};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
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DR EMBL; CH479202; EDW30056.1; -; Genomic_DNA.
DR RefSeq; XP_002024608.1; XM_002024572.1.
DR SMR; B4H179; -.
DR STRING; 7234.B4H179; -.
DR EnsemblMetazoa; FBtr0188147; FBpp0186639; FBgn0160124.
DR eggNOG; KOG4261; Eukaryota.
DR HOGENOM; CLU_000364_1_1_1; -.
DR OMA; VDMTQHY; -.
DR PhylomeDB; B4H179; -.
DR Proteomes; UP000008744; Unassembled WGS sequence.
DR GO; GO:0071944; C:cell periphery; IEA:UniProt.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0005925; C:focal adhesion; IEA:InterPro.
DR GO; GO:0001726; C:ruffle; IEA:InterPro.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
DR GO; GO:0009887; P:animal organ morphogenesis; IEA:UniProt.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR GO; GO:0030182; P:neuron differentiation; IEA:UniProt.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd10569; FERM_C_Talin; 1.
DR CDD; cd17089; FERM_F0_TLN; 1.
DR CDD; cd17090; FERM_F1_TLN; 1.
DR CDD; cd12150; talin-RS; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.20.120.230; Alpha-catenin/vinculin-like; 5.
DR Gene3D; 1.20.1410.10; I/LWEQ domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.20.1420.10; Talin, central domain; 7.
DR InterPro; IPR036723; Alpha-catenin/vinculin-like_sf.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR032425; FERM_f0.
DR InterPro; IPR035964; I/LWEQ_dom_sf.
DR InterPro; IPR002558; ILWEQ_dom.
DR InterPro; IPR002404; IRS_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR037438; Talin1/2-RS.
DR InterPro; IPR015224; Talin_cent.
DR InterPro; IPR036476; Talin_cent_sf.
DR InterPro; IPR049108; Talin_R4.
DR InterPro; IPR015009; Vinculin-bd_dom.
DR PANTHER; PTHR19981:SF1; RHEA, ISOFORM B; 1.
DR PANTHER; PTHR19981; TALIN; 1.
DR Pfam; PF16511; FERM_f0; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF01608; I_LWEQ; 1.
DR Pfam; PF02174; IRS; 1.
DR Pfam; PF09141; Talin_middle; 1.
DR Pfam; PF21692; Talin_R4; 1.
DR Pfam; PF08913; VBS; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM00307; ILWEQ; 1.
DR SMART; SM01244; IRS; 1.
DR SUPFAM; SSF109880; A middle domain of Talin 1; 1.
DR SUPFAM; SSF47220; alpha-catenin/vinculin-like; 4.
DR SUPFAM; SSF109885; I/LWEQ domain; 5.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50945; I_LWEQ; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000008744}.
FT DOMAIN 4..347
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 2219..2460
FT /note="I/LWEQ"
FT /evidence="ECO:0000259|PROSITE:PS50945"
FT REGION 2451..2470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2504..2653
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2703..2728
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2756..2787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 816..843
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1728..1776
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 2504..2522
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2564..2580
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2597..2638
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2767..2787
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2787 AA; 300738 MW; 4C96FF758E28D42D CRC64;
MSTLSLRIQL EGGRVTKTIQ FQPNTTVFDA CKIIRDKFAE AVQGQPSEYG LFISDEQNQQ
GVWLEAGRTL GYYILHNQDT LEYRRKLRTL RVRMLDGAVK TILVDDSQPV SQLMVVICTK
IGITNHEEYG LVREDNEAQN ENLPDNKFGT LTLKRKIMEK DRDAKWKVSA EAQTDDETCE
FAGIQVHIQF GPHNEAKHKP GFLDLKDFLP QSYVRVKGIE KKVFVEHKKH SDLSEIDAKV
LYTKTARELP TYGTTFFLVK EKMNGKNKLV PRLLGVTKDS VLRLDERTKE ILISWPLTTV
RRWGASPNTF TLDFGDYANQ YYSVQTTEAE QIVQLIAGYI DIILKKKQTK DHFGIEGDEG
STMVEESVAP SKATFLQHET NRVEQLNVES LAHPGIMRPY DGERSFTQNE VQTVQYGAFV
GQVNHAHQPP TTKEVRISSV NLTEPQRALL GYISAGQDVL IRADEELRTK APIQELGSDL
RSIEWRENTL DTSKQAVSSH VATMSAATAQ IITASQPDEV DTEAISASVS QIAQTIPEVT
REVRLIAALM ENDTNGDQLL EAARNLCNAF SDLLKAAEPE SKEPPQNLIN AASRVGEATT
HVLSSIAEEE VPENRDLHDM LLALAKAVAN TTAALVLRAK NIAASCEDEQ ARNRVIGAAS
QCALATSQLV ACAKVVAPTL HNAACREQLE AAARNVARAV NSLCEVCNEA SNDPKLKADL
LAAARDVSKS LTDMLEHVKL SSRENASRTS TELSPVENVI IGTDILVSTH DPQEMVRHAR
TLGKTTAQLI QSIKGEAEQQ QDMDMQRRLL SAAKQLADAT AKLVEAAQRL RRAAEELREI
TTTAANTPAM KRSLIQRLEY CSKQAATAAT QCISAAQNAV QHSQDHQTKE SLLQDCKRVA
DTIPRLVTSL KTTRAQPDEP HAQLNLIEAA EQFIEPALQV SKSSRALQPT VTDIPSATQL
SKSALHLGQS VSELHSVAQR ARDACGGQEL ESALEAVRKL HDVLDDTRQA ALAGQLRPLP
GETVENTADE LRKSAKNVGI ALSQLLSSVL QNQRSYAGAA GRDTALALGD FTKSVHGVAA
TTQNPAIIDC ADDVVTSSTR LIEQAQRTLQ GISDPQALTQ AGRDVTGALS ATVDCIPGQR
EVDVALRNVS DLSEILSMSE FPPSGRPYAT LQSELKQVAE HLSSSGGQIV VSYASPALLA
ETSQNFAANY RDLLSVSMEM AGQTQEDSVR SQIIECLRHV STQSCSLLST AKSIAADPGQ
PNAKNLLHAA ARGVTESINQ LVDASIQSAP GQKECDNAMR NIEALRRMLD YPHEPINEQG
YFDCVEQATG KSRNLGYAIS EMINNAKQSQ HVEFSQSVNN VNDSIQGLIE SSSQAAYLIG
VSHPSSVAGR PGIIDQAQLT WAYQGIRQHC DIVSSQQSAK PQMISALTVI AKHTSYLCSI
CRQASMNTSN PVAKNEFIVL AKQVATATSD LVQAIKAIEE QPQGGSRERL VEPLLEAVKA
VRQYASSPEF ISIPAKISAE GRKAQEPVIQ AGRGVIDGVV EMVKAAKSLA LSPDNPPVWQ
QLSMHSTPVS ESVKRLVDNI RDKAPGQAQC EQVLHTLGTC TRELDSCALA VNAQGLSQRR
DNNLHGFSGQ TLNSAAELVD KLEPIRVAGK NNAEQLGHAV GEISRYVVPM VNGAIGACTH
IVHSQQQMSL INQTRSVVES AITLVQSAKD SAGNPRATHA HPRLDEAIDG TREAIQELQQ
TVEKINAETG IVTGLMEQIN RSITRLTDKR QSLLNASYSD TFVDYQTRMV ARAKEIASLA
NEMNAKSSVE PAALPQLAID MTQHYQQLTQ DSVGASTTTS SQDVGMRIRT TVIDLGRSVT
SMIQSSAGGA RPNDVGAQKD IARNAREVSE KVAQVLAALQ AGSRGTQACI NAAHTVSGII
GDLDTTIMFA TAGTLHSEGD GSFADHREHI LQTAKALVED TKVLVTGAAG SQDQLASAAQ
NAVSTITQLA EAVKRGACSL GSSQPDSQVM VINAVKDVAS ALGDLINCTK LASGKSISDP
SMQDLKESAR VMVLNVSSLL KTVKAVEDEH TRGTRAMEAT VEAISQEIRA MQAPPPVGST
QVGPEDLIRV TMNVTAATAK AVAAGASNLQ ADIVSAANLG RRAISDMLIV CRSVAWNCAE
TEELRVRTLE AGTSVGESYR DLLNGILHNC SADDRMHLSR RVAKCVTDLV AMARLLKGSD
WIDPEDPTVI AENELLGAAA SIDAAAKKLA SLRPRRQADV KIELDENMKF DEMILEAAKG
IMAASAALVR AANAAQRELI DQGKVARRPL TSSDDGQWSE GLISAARLVA AATHSLVEAA
QNLVRGVGTE EMLISTAKQV AASTAQLLIA CKVKSNPNSE AGRRLQAAGN AVIKSTDNLV
HAAQQGLEAE EEHSLKINTS MVDGMAQEIN ARSAVLRKEK ELEEARQRLK HVRQAQRYAK
NPQGFTTDES DTEYAYGTLN KSQNNTLGRS GYYASGEIPS SPSYFSGGGG SSSQQKHHYN
YASPQPQHFH HPGAVSPPPA NYPGMDDHDT IGDFPPPPPP LSTTISNMQT ATSGHSFRPN
PKLTANAVPR PYPGSPGGSN GLSSAPTGVG LTPTNANYQH SFESSSTKTQ NSSSSAAAPA
PAAAPAPPAV PQKPQVNRNL EACVQDLHDK TFGQGGVVQL TGGNGYPGQS YEGYTSRYET
RNFDKSANSN NTTSSSEQQQ QQALVKPLES SFSQMTLNTD GGKISIVDQG SERLTSMTQR
VMERKSFTTT TESRSETKTE KHSFRLE
//
