ID B4HH61_DROSE Unreviewed; 1954 AA.
AC B4HH61;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE SubName: Full=GM26622 {ECO:0000313|EMBL:EDW43537.1};
GN Name=Dsec\GM26622 {ECO:0000313|EMBL:EDW43537.1};
GN ORFNames=Dsec_GM26622 {ECO:0000313|EMBL:EDW43537.1};
OS Drosophila sechellia (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7238 {ECO:0000313|Proteomes:UP000001292};
RN [1] {ECO:0000313|EMBL:EDW43537.1, ECO:0000313|Proteomes:UP000001292}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Rob3c / Tucson 14021-0248.25
RC {ECO:0000313|Proteomes:UP000001292};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; CH480815; EDW43537.1; -; Genomic_DNA.
DR RefSeq; XP_002032551.1; XM_002032515.1.
DR SMR; B4HH61; -.
DR STRING; 7238.B4HH61; -.
DR EnsemblMetazoa; FBtr0209607; FBpp0208099; FBgn0181475.
DR GeneID; 6607793; -.
DR KEGG; dse:6607793; -.
DR HOGENOM; CLU_231302_0_0_1; -.
DR OMA; DFGIIRY; -.
DR OrthoDB; 53079at2759; -.
DR PhylomeDB; B4HH61; -.
DR Proteomes; UP000001292; Unassembled WGS sequence.
DR GO; GO:0005813; C:centrosome; IEA:EnsemblMetazoa.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005875; C:microtubule associated complex; IEA:EnsemblMetazoa.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000922; C:spindle pole; IEA:EnsemblMetazoa.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0008017; F:microtubule binding; IEA:EnsemblMetazoa.
DR GO; GO:0032027; F:myosin light chain binding; IEA:EnsemblMetazoa.
DR GO; GO:0030954; P:astral microtubule nucleation; IEA:EnsemblMetazoa.
DR GO; GO:0048854; P:brain morphogenesis; IEA:EnsemblMetazoa.
DR GO; GO:0051298; P:centrosome duplication; IEA:EnsemblMetazoa.
DR GO; GO:0051642; P:centrosome localization; IEA:EnsemblMetazoa.
DR GO; GO:0007282; P:cystoblast division; IEA:EnsemblMetazoa.
DR GO; GO:0051295; P:establishment of meiotic spindle localization; IEA:EnsemblMetazoa.
DR GO; GO:0000132; P:establishment of mitotic spindle orientation; IEA:EnsemblMetazoa.
DR GO; GO:0048132; P:female germ-line stem cell asymmetric division; IEA:EnsemblMetazoa.
DR GO; GO:0030706; P:germarium-derived oocyte differentiation; IEA:EnsemblMetazoa.
DR GO; GO:0051383; P:kinetochore organization; IEA:EnsemblMetazoa.
DR GO; GO:0007052; P:mitotic spindle organization; IEA:EnsemblMetazoa.
DR GO; GO:0007097; P:nuclear migration; IEA:EnsemblMetazoa.
DR GO; GO:0030723; P:ovarian fusome organization; IEA:EnsemblMetazoa.
DR CDD; cd21223; CH_ASPM_rpt1; 1.
DR Gene3D; 1.20.5.190; -; 2.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR InterPro; IPR031549; ASH.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR PANTHER; PTHR22706:SF1; ABNORMAL SPINDLE-LIKE MICROCEPHALY-ASSOCIATED PROTEIN ISOFORM X1; 1.
DR PANTHER; PTHR22706; UNCHARACTERIZED; 1.
DR Pfam; PF15780; ASH; 1.
DR Pfam; PF00612; IQ; 5.
DR SMART; SM00033; CH; 1.
DR SMART; SM00015; IQ; 16.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50096; IQ; 5.
PE 4: Predicted;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000001292}.
FT DOMAIN 836..968
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REGION 170..206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 476..500
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 512..549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 529..546
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1954 AA; 230269 MW; 84E2946ADAFEA4BF CRC64;
MSAFEITVTP SRLKQKKRAE GREPAVVVMA PFSAKAIVQF EDVPITKTAR RQVRVLNPSE
DDIEVKVMKA IREEHNLSLE WMEHTVPARD EVSMELVWSP VLEVACKETL QLIDNRNFRK
EVMIILKSKS NQPVKNPRKF PTVGKTLQLK SPTGVGKTMK SVVSAAVQQK RRMSAAAAPP
SKQPWRVTAP SRHAARPHPP PQAPLVEKNV YKTPQEEPVY ISPQPRSLKE NLSPMTPGNL
LDVIDNLRFT PLTETRGKEQ ATIMPDNLAA WPTPTLKGNV RQCANDMRPR RITPDDLEDQ
PATNKTFDVK HSETINISLD TLDCSRIDGQ PHTPLNKTTT IVHATHTRAL ACIHEEEGPS
PPRTPTKSAI HDLKRDIKLV GSPLRKYSES MKDLSLLSPQ TKYAIQGSMP NLNEMKIRSI
EQNRYYQEQQ IQIKTKDLNS SSSSEASLAG QQEFLFNHSE ILAQSSRFNL HEVGRKSVKG
SPVKNPHKRR SHELSFSDAP SNESLYRNET IAISPPKKQR VEDTTLPRSA APANASARSS
SAHAWPHAQS KKFKLAQTMS LMKKPTTPRK ARETSVQPSV KLYDSELYMQ TCINPDPFAA
TTTIDPFLAS TMYLDEQAVD RHQADFKKWL NALVSIPADL DADLNNKIDV GKLFNEVRNK
ELVVAPTKEE QSMNYLTKYR LETLRKAAVE LFFSEQMRVP CSKVAVYVNK QALRIRSDRN
LHLDVVMQRT ILELLLCFNP LWLRLGLEVV FGEKIQMQSN RDIVGLSTFI LNRLFRNKCE
EQRYSKAYTL TEEYAETIKK HSLQKILFLL LFLDQAKQKR IVKHNPCLFV KKSPHKETKD
ILLRFSSELL ANIGDITREL RRLGYVLQHR QTFLDEFDYA FNNLAVDLRD GVRLTRVMEV
ILLRDDLTRQ LRVPAISRLQ RIFNVKLALG ALGEANFQLG GDIAAQDIVD GHREKTLSLL
WQLIYKFRSP KFHAAATVLQ KWWRRHWLYV VIHRRIRHKE LMRRHRAATV IQAVFRGHQM
RKYVKLFKAE RTQAAIVLQK FTRRYLAQKQ LYQSYHSIIT MQRWWRAQQL GKQYRQRFLE
LREAAIFLQR IWRRRLFAKK LLAAAETARL QRSQKQQAAA SYIQMQWRSY QLGKVQRQRF
LRQRDLIMFV QRRMRSKWSM LEQRKEFQKL KRAAINVQQR WRAKLSMRKC NSEYLALRSS
VLKVQAYRKA IIQMRIERNH YYSVRKNVIC LQQRLRATIK MREQRENYLR LRNALILVQK
RYRMRQQMIQ DRKAYLKTRQ CIINVQRRWK ATLQMRQDRK NYLQLQSTTK LIQIKFRAKR
EMEKQRAQFL ELKKVSLVVQ QRRRALLQMR KERQEYLHLR EVTIKLQRRF HAQKSMRFIR
AKYRGTQAAV SCLQMHWRSH LLRKRQRNSF LQLRQAAITL QRRYRARLSM IKQLKSYAQL
KQAATTTQTR YRAKKAMQKQ VVLYQKQREA IIKVQRRYRG KLEMRRQIEV YQKQRQAVIR
LQKWWRSIRD MRLCKAGYRR IRLSSLSIQR KWRATVQARR QREIFLSTIR KVRLMQAFIR
ATLLMRQQRR EFETKRVAAI VLQRRFRARC AMLKARQDYQ LIQSSVILVQ RKFRANRSMK
QARQEFVQLR TITVHLQQKF RGKRLMIEQR NCFELLRRSM PDFQARARGF MARKRFQALM
TPEMIDLIRQ KRAAKVIQRY WRGYLIRRRQ KHQGLLAIRK RIAQLRQEAK AVNSVRCKVQ
EAVRFLRGRF IASDALAVLT RLDRLSRTVP HLLMWCSEFM STFCYGIMAQ AIRSEVDKQL
IERCSRIILN LARYNSTTVN TFQEGGLVTI AQMLLRWCDK DSEIFNTLCT LIWVFAHCPK
KRKIIHDYMT NPEAIYMVRE TKKLVARKEK MKQNARKPPP ITTGRYKSQK INFTPCSLPS
LEPDFGIIRY SPYTFISSVY AFDTILCKLQ IDMF
//
