ID B4HLZ6_DROSE Unreviewed; 2181 AA.
AC B4HLZ6;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 24-JAN-2024, entry version 85.
DE RecName: Full=U5 small nuclear ribonucleoprotein 200 kDa helicase {ECO:0000256|ARBA:ARBA00034541};
GN Name=Dsec\GM24241 {ECO:0000313|EMBL:EDW42033.1};
GN ORFNames=Dsec_GM24241 {ECO:0000313|EMBL:EDW42033.1};
OS Drosophila sechellia (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7238 {ECO:0000313|Proteomes:UP000001292};
RN [1] {ECO:0000313|EMBL:EDW42033.1, ECO:0000313|Proteomes:UP000001292}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Rob3c / Tucson 14021-0248.25
RC {ECO:0000313|Proteomes:UP000001292};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
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DR EMBL; CH480815; EDW42033.1; -; Genomic_DNA.
DR RefSeq; XP_002031047.1; XM_002031011.1.
DR SMR; B4HLZ6; -.
DR STRING; 7238.B4HLZ6; -.
DR EnsemblMetazoa; FBtr0207226; FBpp0205718; FBgn0179105.
DR HOGENOM; CLU_000335_2_1_1; -.
DR OMA; MCSATEF; -.
DR OrthoDB; 57056at2759; -.
DR PhylomeDB; B4HLZ6; -.
DR Proteomes; UP000001292; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProt.
DR CDD; cd18020; DEXHc_ASCC3_1; 1.
DR CDD; cd18022; DEXHc_ASCC3_2; 1.
DR CDD; cd18795; SF2_C_Ski2; 2.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041094; Brr2_helicase_PWI.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR47961; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR PANTHER; PTHR47961:SF13; SEC63 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00270; DEAD; 2.
DR Pfam; PF00271; Helicase_C; 2.
DR Pfam; PF18149; Helicase_PWI; 1.
DR Pfam; PF02889; Sec63; 2.
DR PIRSF; PIRSF039073; BRR2; 1.
DR SMART; SM00382; AAA; 2.
DR SMART; SM00487; DEXDc; 2.
DR SMART; SM00490; HELICc; 2.
DR SMART; SM00973; Sec63; 2.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 2.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 2.
DR PROSITE; PS51194; HELICASE_CTER; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001292}.
FT DOMAIN 494..677
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 712..926
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 1344..1520
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1556..1748
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 2181 AA; 248896 MW; CFA1F16FB3DC5B8F CRC64;
MWEPPRLSAS LRAKTELEAR SRRLNVLRQA RTTSAASTTT NSQNKEEQTI ARLLAQMPTE
KQPAAKVQLQ KLRNLVQECM GYEEQPQVVE HAALFLFWLL LDQRVLLVAT TQRLHGMFGQ
TFDRKKNQIH DCVQAIGDML EDHERSALKR WRQTHHKANG VGLLWGAHIH VKCTPSEWMD
ISLLTDLAPD ALLKNRTVNK FSMKHKTKAA PAASTSSESA KLSPELQTLL EISEKLDDEH
LISRVGDILG SQRSSEVLQN ELMEILGFDH FELVEKLLQD RNKIARQLDQ FATRSRRVME
VKQKRIETAA SGGAAERRPT VASAVVVQSA QEKQLGKMQR REEKKLQRIM RSIKDDELED
DPNCAVAVSV QQLRMQHQRK LLEAAQREPL LFSTKAEFKQ SKQYNQPIHY PYVFDSQLLA
KQHAGFIGGS RITLPDNAQR IDNKQWEEVK IPASEPPPLS VGNKRVQIEE LDDVGRLAFA
NCKELNRIQS VVYPVAYHSN ENMLVCAPTG AGKTNVAMLS IVHTIRCHLE QGIINRDEFK
IVYIAPMKAL AAEMVDNFSK RLKSLQIVVR ELTGDIQLTK AEMAATQILV TTPEKWDVVT
RKGSGDVGLI SLVELLIIDE VHLLHGERGP VVEALVARTL RLVESSQSMI RIVGLSATLP
NYIDVAHFLR VNPMKGLFYF DSRFRPVPLD TNFVGIKSVK PLQQIADMDQ CCYQKCVEMV
QEGHQIMVFV HARNATVRTA NVIRELAQQN NTSALFLPKD SAAHGLATRS IQRSRNKQLV
ELFSSGLAMH HAGMLRADRQ MVEKYFVEGH ISVLVCTATL AWGVNLPAHA VIIRGTDIYD
AKHGSFVDLG ILDVLQIFGR AGRPQFDKSG VGTIITSYDK LNHYLSLLTN QFPIESNFVN
CLADNLNAEI GLGTITNVDE AIEWLSYTYL FVRMRINPHV YGIEYSELEK DPTLEARRRA
LIMSAAMSLD KARMMRFNQR TMDMNITDLG RTASYFYIKY DTVETFNELM KPFMTQAEIL
AMISQAQEFQ QLKVRDDEME ELDELKSAYC KIKPYGGSEN VHGKVNILIQ TYLSNGYVKS
FSLSSDMSYI TTNIGRISRA LFSIVLRQNN AVLSGNMLQL CKMFERRQWD FDCHLRQFPA
INAETIDKLE RRGLSVYRLR DMEHRELKEW LRSSTYADLV IRSAHELPLL EVEASLQPIT
RTVLRIKVDI WPSFTWNDRV HGKTCQSFWL WIEDPESNYI YHSELFQVTR KLVMSGQSQQ
LVMTIPLKEP LPPQYYIRVS SDNWLGSTTC VPLSFQHLVL PEHHPPLTEL LPLRPLPVSC
LKNVLYESLY KFTHFNPIQT QIFHCLYHTD NNVLLGAPTG SGKTIVAEIA IFRALNQNPK
CKVVYIAPLK ALVKERIADW EQRFQRSSLG LKVVELTGDV TPDIQAIRES QLIVTTPEKW
DGISRSWQTR EYVQHVSLIV IDEIHLLGED RGPVIEVIVS RTNFISSHTG RDIRIVGLST
ALANAQDLAN WLGIKKMGLY NFKPSVRPVP LQVHINGFPG KHYCPRMATM NRPTFQAIRT
YSPCEPTIVF VSSRRQTRLT ALDLITFVAG ESNPKQFLHM AEDEIELILQ NIREQNLKFC
LAFGIGLHHA GLQEQDRKCV EELFLNRKIQ VLVATATLAW GVNLPAHLVV IKGTEYFDGK
VKKYVDMPIT DVLQMMGRAG RPQFDNEGVA VVLVHDEKKN FYKKFLYDPF PVESSLLGVL
PEHINAEIVA GTVQSKQAAL DYLTWTYFFR RLLRNPSYYQ LQDIEPENVN KFMSNLVERV
VYELSAAACL VERDGCLVPT FLGRISSYYY LSYRTMQHFL EDLQPGMSTK KVLLAIADSY
EFDQLPVRHN EDKHNEQMAE VSRFRPPSSS WDSSYTKTFL LLQAHFARQS LPNSDYLTDT
KSALDNATRV MQAMVDYTAE RGWLSTTLVV QQLMQSVIQA RWFDGSEFLT LPGVNEDNLD
AFLNIPHDDY DYLTLPVLKE LCKQEYEVLA KPLRDAFEEH EIEQMYKVIK DLPEIALQIF
VEGRHMENEY AKRPLSLSHD TRGEWMSLHA NEDYVLIVNL QRLNVSGQRR GGGQSYTVHC
PKYPKPKNEA WFLTLGSQAN DELLAMKRVS IRGQRCTNRI SFQATPRLGR LQLTLYLMSD
CLLGFDQQYD LHFEIIDAKE A
//
