ID B4HX35_DROSE Unreviewed; 2008 AA.
AC B4HX35;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 92.
DE SubName: Full=GM18973 {ECO:0000313|EMBL:EDW52580.1};
GN Name=Dsec\GM18973 {ECO:0000313|EMBL:EDW52580.1};
GN ORFNames=Dsec_GM18973 {ECO:0000313|EMBL:EDW52580.1};
OS Drosophila sechellia (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7238 {ECO:0000313|Proteomes:UP000001292};
RN [1] {ECO:0000313|EMBL:EDW52580.1, ECO:0000313|Proteomes:UP000001292}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Rob3c / Tucson 14021-0248.25
RC {ECO:0000313|Proteomes:UP000001292};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR EMBL; CH480818; EDW52580.1; -; Genomic_DNA.
DR RefSeq; XP_002036657.1; XM_002036621.1.
DR STRING; 7238.B4HX35; -.
DR EnsemblMetazoa; FBtr0201958; FBpp0200450; FBgn0173876.
DR GeneID; 6612140; -.
DR KEGG; dse:6612140; -.
DR HOGENOM; CLU_231123_0_0_1; -.
DR OMA; SEYNFKM; -.
DR OrthoDB; 3456149at2759; -.
DR PhylomeDB; B4HX35; -.
DR Proteomes; UP000001292; Unassembled WGS sequence.
DR GO; GO:0015630; C:microtubule cytoskeleton; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47968; CENTROMERE PROTEIN E; 1.
DR PANTHER; PTHR47968:SF36; CENTROMERE-ASSOCIATED PROTEIN E; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF57997; Tropomyosin; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000001292}.
FT DOMAIN 8..313
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT REGION 388..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1911..1938
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 494..535
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 627..801
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 934..968
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1046..1073
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1124..1158
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1182..1281
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1340..1388
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1445..1605
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1729..1883
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 83..90
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 2008 AA; 229681 MW; 246EB64F59066395 CRC64;
MSAKNASSIQ VCIKVRPCEP GLTSLWQVKE GRSIHLADSH AEPYVFDYVF DEGASNQDVF
DRMARHIVHA CMQGFNGTIF AYGQTSSGKT YTMMGDEQNP GVMVLAAKEI FQQITSETER
DFLLRVGYIE IYNEKIYDLL NKKNQDLMIH ESGNGIVNVN CKESIVTSED DLLRLLCMGN
KERIVGENNM NERSSRSHAI FRIIIESRKS DHSDDDTVNQ SVLSLVDLAG SEQVEHADAL
GHASSLMIFR NLVKSRSENV DIKPNSFRDS KLPRIMLPSL GENVLTSIIC TITPSFVEES
SSTISFATCA IKIRCKPQVC KMDSESTMMG RLDRGICMLK KKLAEKKIKN ESQLVLQELE
GRIKRDKLKI ISSASLNDYR LQKRRRTWTL SASGSEGDSS VPALPEPEES RLPRPSKLTN
LPKPNTTHSQ RREIAPKTKG IYKSLKEKTF QTDNMNTMPV QAKQRETASR IPSVMMPKKD
QESVPNCDAL QIEISALTAS NQVAKETIEK YEEQVKRLKE TIERLEMENG KAVNLGEQFE
THKAKSKQMK EELLSSIFEK DSTIESLQLS LKELSRDVLR NSKEDFMRSM CPELESSCER
ICNKCLELER LLPIASASGL ESIACQCDQL RSEIADTRIK LESMQSAFSQ ASCEVSQKTT
DCKRLSEQIS TAQDDFGQLQ EKYNNLEHKL SSQQLAIGTM QADYTSIQQR YLQLQEEYKH
LELRSDEQCQ QLQDENSKLQ AEIGTLKERV EEVQSKLLEV PNPGSHPGEM ELQNRQLKKR
LSELESEFNE IRRNYECLST QLMDSIQESD VLREELKQRT TNGDLESMKR SGVGAQCSDP
ENDLLQQFAK LSKSIQQIEL SDYSGGRRLF IHNHAEQDQS VPSFKLCLEP ADYLKGDGKQ
QDTSDSVFLK GSQIVKINQE QNCVKEEDRM CDIILQLKQE VDEKKNLIEE EKGVIDKLRA
QITSLKQIET VVNQNGKTKI LCDELQTEDN VQTTMKQSLL SIPHGDDTIT IPSSANEQES
HEVLTLKTSL AHLKSKVCEL QKKLENQSED EKISELQADI GEISERCLSM EQKLADFVNW
QAQELRPLDQ LQDSGAELQH SSTTAEESLK LEKPIQEQTD RTLTTEYERR IEQLEESLQR
AQEELRILEK RKTDENKSLQ LEYMAKIETS ENENRSKFRA YCLELEETKK RYEEQLQQAS
EKLTSVTTQC QADLDVIKGS LQEKITQAEK ERNELAARHK AELEKINETL KEKESSYKEK
LSQAEEERDK EVSILEAMRN TIAELHKTNS KREVELEGVK MEKCQLKELY DKSLLELKEL
QRTADQKSSD LLAGSSKEDI DELQRKCDQY VMDLELLRGE KAELLSEIQK INAQHSKTLK
KLEEIEAEMI TLTTQKDLER CDIKEKLETF KSKEADLKEA LHCAQLRFHA YDELVCEHER
LKGCLSDSNK MSANLQKKVA DLQAELLSLQ EGISGRDSEI KQLRAELKDA LDENTTARKA
KVDLENSLKE VQENMSTQAG EVKRKIANLK GSVDELQLKL KSLQEVKDNL ESENEKLKIK
LNDAQNLQNK VDKEQKLNSS LREDLGKLEQ TKLGLEEQLR AKKVEIDRRS KELGELTQEC
GNIRSHLAAQ TNDFLKEKET LNLTISNLQL HYQQLGEKLT IHREKDKCQC QLKTKLESLL
ETSKDHVSNK AAENNLNLQM KKDILDLTKE CEILRSDLQS KIEYFRTHEQ LLDKTISNLK
EENRKMEEKF STVNKALNED CEKLRSTLKS KELIMQQNRQ ELEERLTVID EKNGINARLV
AQLKSNEDAL KSLREDSIKQ SLAIEAANKR SHEMEQKVNK RAREYEELRS TLKTREIHFR
SEKERMDGTI SILLEDKRNL EEKVCTVTEL LAKLERKHAQ KVNGGDVSFE LNSSNGSPTP
VAVPATKKPL DCNSADSVPK KSISLDTAER KNRRMTAYDE HRKQFCWNDL RNGGTTTVPV
DGNCHCEQLS CKQRLSSDWR QNDNKKDD
//
