ID B4HXF7_DROSE Unreviewed; 2682 AA.
AC B4HXF7;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE SubName: Full=GM15516 {ECO:0000313|EMBL:EDW51737.1};
DE Flags: Fragment;
GN Name=Dsec\GM15516 {ECO:0000313|EMBL:EDW51737.1};
GN ORFNames=Dsec_GM15516 {ECO:0000313|EMBL:EDW51737.1};
OS Drosophila sechellia (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7238 {ECO:0000313|Proteomes:UP000001292};
RN [1] {ECO:0000313|EMBL:EDW51737.1, ECO:0000313|Proteomes:UP000001292}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Rob3c / Tucson 14021-0248.25
RC {ECO:0000313|Proteomes:UP000001292};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix, basement membrane {ECO:0000256|ARBA:ARBA00004302}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR EMBL; CH480818; EDW51737.1; -; Genomic_DNA.
DR RefSeq; XP_002035814.1; XM_002035778.1.
DR SMR; B4HXF7; -.
DR STRING; 7238.B4HXF7; -.
DR EnsemblMetazoa; FBtr0198501; FBpp0196993; FBgn0170434.
DR GeneID; 6611259; -.
DR KEGG; dse:6611259; -.
DR HOGENOM; CLU_000301_0_1_1; -.
DR OMA; TVRQHVH; -.
DR OrthoDB; 90222at2759; -.
DR PhylomeDB; B4HXF7; -.
DR Proteomes; UP000001292; Unassembled WGS sequence.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0007502; P:digestive tract mesoderm development; IEA:EnsemblMetazoa.
DR GO; GO:0010669; P:epithelial structure maintenance; IEA:EnsemblMetazoa.
DR GO; GO:0008406; P:gonad development; IEA:EnsemblMetazoa.
DR CDD; cd00055; EGF_Lam; 13.
DR CDD; cd00110; LamG; 4.
DR Gene3D; 2.60.120.200; -; 5.
DR Gene3D; 2.10.25.10; Laminin; 12.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR000034; Laminin_IV.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR10574:SF365; NETRIN-A-RELATED; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00052; Laminin_B; 2.
DR Pfam; PF00053; Laminin_EGF; 12.
DR Pfam; PF02210; Laminin_G_2; 4.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 7.
DR SMART; SM00180; EGF_Lam; 13.
DR SMART; SM00281; LamB; 1.
DR SMART; SM00282; LamG; 5.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 5.
DR SUPFAM; SSF57196; EGF/Laminin; 10.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01248; EGF_LAM_1; 5.
DR PROSITE; PS50027; EGF_LAM_2; 11.
DR PROSITE; PS50025; LAM_G_DOMAIN; 4.
DR PROSITE; PS51115; LAMININ_IVA; 2.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000001292};
KW Secreted {ECO:0000256|ARBA:ARBA00022530}.
FT DOMAIN 1..121
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 159..208
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 281..324
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 325..371
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 372..416
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 457..505
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 506..553
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 601..646
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 647..701
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 742..934
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 977..1024
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1025..1079
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1080..1127
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1891..2079
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2083..2302
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2314..2492
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 2497..2675
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DISULFID 178..187
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 298..307
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 325..337
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 327..344
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 346..355
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 394..403
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 457..469
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 459..476
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 478..487
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 506..518
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 508..525
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 527..536
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 601..613
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 603..620
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 622..631
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 672..681
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 996..1005
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1008..1022
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1049..1058
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1080..1092
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1082..1099
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1101..1110
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 2648..2675
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00122"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EDW51737.1"
SQ SEQUENCE 2682 AA; 298443 MW; 2FD31E19D6148A48 CRC64;
GKPTTGPNVI LVGKNGLKIA FGDESLDGLG VNLNITLTEV GWYHVPPTVV DIKTRLRRTE
GGDYHGESVT RSQFLSVLVS LDAVLIRAAF HTDQGETSLE RAVIYSGGVE LGGKSSSQVE
QCLCPAGYTG LSCEGCAFGF KRIYENTSDH QILSKCIPCP CNGHSNSCDL QSGNCGDCMH
NTFGDRCERC QLGYYGNPLQ GTPNDCKRCA CPLPEDSNNF SPSCQLKSYN YMDLNPQFEL
IEHAEYICTQ CPEGYTGDHC QVCDDGYFGN PRQLGSSCQR CDCAGGPCNV TTGECITCRG
NTEGWHCERC KLGYWGDPAV GCDPCHCHTE GSESGLCDST DGQCLCKPRY AGQKCDECDV
GYANVELRCP SCNCDPLGSL DQDRCDPHTG QCHCKEGVMG AKCHECQDGY FGMNAVADRM
DDLAALRQNS DSDDDDWELV PDTEDPNSES AVACEECHCS SVGSLSSDCD KRTGQCACLA
NVTGRRCDKC RPGHWNLTAG EGCRDCRCDP HGSRGHECNP WTGQCDCKIG VGGQHCNECT
EGFFGFSTEG CQRCSACRSE GQVCDPHNGR CICPKFTRGL GCGQCVPGTW GWQARLGCRE
CECDHIGSIG QQCSTGDGQC QCREGYSGRK CDTCAIGYFG YPECRRCGCD AEGSFTQADG
SIACDSNGQC PCKSLVVGLK CDTCMQSTFG LSALNPEGCT RCFCFGRSGE CEQSDLSWGH
IRMAESRNLS VQQIRPHSVP SSDYEYIVVV QMEGSSFHRE DAEIQRMNDL SLVPKSTGNV
SIGAYGQFYH PLYFQLPPQF YGDRTSSYGG FLYFTLITEG AHKPLERNIL GQYPLVQLHA
HSKLLLDFYE YEEFEYSLNV THRVPLHESF WKYHHTSQAV DRNTLMAALQ NIRHIFIRAF
AFADFQEVVL QNVHMDAAIY IKGSTNLIAK GVERCRCPKR FDGLSCQDPG RSFYRWRNTT
VVESVFIEDL IGRAAPCHCN GRSSDCDRET GVCQNCRGNT GGDHCHQCAE GFYGDPNSPH
GCQACPCPET NRNFARGCNV WDGEVSCVCK PGYTGRLCER CQAGYFGDPM RYPNTTCQPC
NCHPDGIQTE GCDVETGRCF CREGVTGHKC DKCQAERHHL VDNGCKICDN CTLLLLDYVE
LVGNKLRRGM HNMDLTGIPA PYRKLSEYES AYEKWNGRHW DFSQTKRRLK DYDSADILKL
EAHAENLKFQ SRKAVATIGK REFAIKSMRE DAVTQQHSVG LLRSEILQTL SDLHGYGKSA
HYLSLPTALK QARFYLQAIR EHDQMVQGIR STNDCAWKHF YAMGNASDAS FDESGRLEML
WRDLNQTNHR VVDMRLQVDR VQEVENEAED VLEHVRNLSI HVGESHQELD ELNQRISDHL
DPGYLEQGEG LLRLTVQRQI LLNGHLNQLD GYRVLLNTTL GVKTEQQREV RKHWLPKAEK
HANHLLARSN EYARKFQPTR NGARIAMLAS SAHSNITKAI NDARLASILA KERVYEAQRT
LYPSDGSSMI ERAKHSLHRS KQLQQEALKQ MHKSNVLKDK LHRQEQQVEG IKSSIYDSGL
RTNNISGQLQ GLSDGSARRQ AKDSLEMADR TGEQMRAELR KAKDMQESIQ NMRSSFSNLE
PDWEIKLGMA QENISLTQTN LRLANVSLSY LEQQAEKEQQ VFEVWNNSMA QQLQQLRDQI
AKARHAAEAI DVSLESLGPK CIRSYLPASY GLSTSNKIRM SFALSNHLES SPLIHLASSE
GRHITLELYK RRVRLVWNLG GTTATVTHPM VVHTRDPKYD DAWYHVEANR TLNLGSLVVR
RMNNYGELTP PNPVTITGST DTEHTRFYQS RSDRISLGGF ASKDLQFTPG LNVVVHQVEV
DNKPLGLWNF VTSEGSCGGS MVGAKESSAS STARHFNGLG YAQLMKTRPR PTRKNLFSVQ
MTFRTLDENA LLFLAVDDKN NRSVSVTLSR GRIMFRIDYG DESKLEINTT KKYNVGQWIK
IEAAREFSAK RSTENGMLRV NNDRPISGAP TLPVNIHLLP DLSKTVYYLG GVPPGFTSGT
SKAPGADNPF LGCMKDVQVN GETYDPLESS SYYGVEPSCK DMITKAGFSG NGYLELPSQS
LRKRSNTALV FRTLQPDCLL LLAAYPPEIL GDYDAKDIKG NFSISLVDGQ LHVWVNSGRS
FIKMSSNSSQ MNDGEFHVVH LIKTGRKLEL MVDDELQEIR NLNGNPTVVS LPRDAGGLYI
GGAPAHESYT PLAPTFVNLE GAIRDVVFNN RTINFNDALT FSNVQIGRNG PLMGSLKGGL
YDVLLKTEPM IGKSFTASPE GCKRIGSYSY EPNAFKFGDD IYSYSQLKLP ERHFWQRNFH
LSFDFRSFYP NGMLYLSPGS KEKPKHYVAL VLKDGQLVLV VRGRRREELQ LTAKLNDGEW
HRVTISCHDR KVTMSVEIGR TDQKTSAQMK LPKKIGASQL LLVGGLPQSP VKVSSDLYVR
LEPFKGCLRR VSINNNTQDL ARPGKHSNVG QCFPTVERGS YFPGDAYAIY KKNFNVGKYL
DLETEFRTSE LSGILLSVSD PNGFPALSLE LHNGNIIFSC DPGNGAPMRV ESSLPTKYAL
CDNKWHNISA LYDGEQIVLR IDQLPAVISV GNQGNAGKVQ TRSPLYIGGL PESAPSGSLI
SRENFKGCIR HVSIRNERRD WIEMEDLRNV LLSECLVSSD ES
//
