ID B4HXM8_DROSE Unreviewed; 1380 AA.
AC B4HXM8;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=GM14522 {ECO:0000313|EMBL:EDW51808.1};
GN Name=Dsec\GM14522 {ECO:0000313|EMBL:EDW51808.1};
GN ORFNames=Dsec_GM14522 {ECO:0000313|EMBL:EDW51808.1};
OS Drosophila sechellia (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7238 {ECO:0000313|Proteomes:UP000001292};
RN [1] {ECO:0000313|EMBL:EDW51808.1, ECO:0000313|Proteomes:UP000001292}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Rob3c / Tucson 14021-0248.25
RC {ECO:0000313|Proteomes:UP000001292};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
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DR EMBL; CH480818; EDW51808.1; -; Genomic_DNA.
DR RefSeq; XP_002035885.1; XM_002035849.1.
DR STRING; 7238.B4HXM8; -.
DR EnsemblMetazoa; FBtr0197507; FBpp0195999; FBgn0169444.
DR HOGENOM; CLU_006060_1_0_1; -.
DR OMA; ECDCEIA; -.
DR PhylomeDB; B4HXM8; -.
DR Proteomes; UP000001292; Unassembled WGS sequence.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 10.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45712; AGAP008170-PA; 1.
DR PANTHER; PTHR45712:SF22; LEUCINE RICH REPEAT FAMILY PROTEIN; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13516; LRR_6; 1.
DR Pfam; PF13855; LRR_8; 7.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00364; LRR_BAC; 15.
DR SMART; SM00365; LRR_SD22; 9.
DR SMART; SM00369; LRR_TYP; 33.
DR SUPFAM; SSF52058; L domain-like; 4.
DR PROSITE; PS51450; LRR; 10.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000001292};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..1380
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002806320"
FT REGION 21..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1380 AA; 156094 MW; 790089A92CC9E649 CRC64;
MHLYLVLISC LVSSSHCWQF DGGGGHRRPR NTGRGPASST GGRGSAALLG SQQQDILYAC
PLNSMCQCAG LPNETSTLIE INCNEVALYK FPGSARILCL WLDRKTSTES KAWLHRRRGI
GLDYGPWTMC HGLGPLWSTG LAEFMHSSVR YIEMSNTHLQ SVDDETFQGL RLKTLKLIDN
ELQDISERSF STMTHSLMTL DISGNKMQHL PLDALQRLHS LSRLVAQRNH ITTLDGNWDA
QHDTLRSLHL SDNDITEVAP GGGSIEVVSQ NDNSSQPSSL AAVQTRLETS NSIYPPSPSS
GDRVTGGRPF EQLQKLLWLD LSNNRIYNVA GNYLPRSLVT MDLSSNLLTV FPQQLFEQLP
ELRIVSLRDN LIRSVQWKEL QVRPLRMHLE RLDLGQNCIE NLESDYFQQN YSDVHLRALN
LEQNFVTQLP EAVFKATGIA HLVLAFNAIS RVHPSAFEGL TETLEYLDLE RNRLTTVPVA
LSSLHHLKYL YLTSNQISQL NNLPSFTENL RVLSLSGNNF TMIPVLGLKN YTQLSYLNMG
YNSITDIPEG IFAVDSWGSN LQTILLRNNK ITHLHLGSFA GLEQIQEISL SFNDITIHHP
LVFENVSRTL KILELSFAVF PARSLESLDP LDALLPLSQL IWLGLDNNNL KQVSNESFAQ
MRELSYINLS FNQLKTLPRG LFQSDAHSHL VEIDLSYNGL ERLEAQTFHS LGDLQTLNLQ
SNRLRTIARH AFHNLEFLRY LDLSYNRLVN ISHGAFTVLP NLAALDLMHN QLCSLSLKSF
LYVSNTTTPL RLNVSHNHIA SFYDELSSYM YIYQLDISHN HVTKSDSFTN LANTLRFLNL
AHNQLGSLQS HAFGDLEFLE ILNVAHNNIT SLRRRSFQGL NSLQELDLSH NQLDQLQVEQ
FSNLRKLRIL RINSNRLRAL PREVFMNTRL EFLDIADNQL SVWPVPAFTD IGFTLRSIQM
SHNNLEYLDA SMFINSQFLY DISLARNRIT ILPDNTFSFL NNLTNLDLSQ NPLVTTNLRE
VFVHTPRLRK LSLHHMGLYV LPPLKLPLLS YLDVSGNYLQ ELSPLGSLRH LRHVNVSHNK
LTNASCAAEH LPPSVRVLDL AHNPLRRISL HDLASLRHLA ELNILDVKVT NPQAFSKLRS
LRKLHASSHA NLGEIVARMP GLQQLRVHCL EPNIGQQLFA KLANNTKIRL LELYGSNVQT
IAPDVFTGLS RSQRLQVKIS HTRISDLPPG IFYALREVPH LSIDISHNRI NALAADSFYP
NKSYWDAVGT RSIMGGLITS HNPLECECGL VWFGHWLRRW LRESAQIKVI QKDDLKRMVQ
RARANTCHDP TSGRHLPILE IFPEDLLCQA SALSSSGQRI FLLSFAMALL IPIVMTTMTL
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