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Database: UniProt
Entry: B4I2V4_DROSE
LinkDB: B4I2V4_DROSE
Original site: B4I2V4_DROSE 
ID   B4I2V4_DROSE            Unreviewed;      3089 AA.
AC   B4I2V4;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   23-MAY-2018, entry version 73.
DE   SubName: Full=GM18393 {ECO:0000313|EMBL:EDW54099.1};
GN   Name=Dsec\GM18393 {ECO:0000313|EMBL:EDW54099.1};
GN   ORFNames=Dsec_GM18393 {ECO:0000313|EMBL:EDW54099.1}, GM18393
GN   {ECO:0000313|FlyBase:FBgn0173300};
OS   Drosophila sechellia (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7238 {ECO:0000313|Proteomes:UP000001292};
RN   [1] {ECO:0000313|EMBL:EDW54099.1, ECO:0000313|Proteomes:UP000001292}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Rob3c / Tucson 14021-0248.25
RC   {ECO:0000313|Proteomes:UP000001292};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 Genomes Consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
RA   Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
RA   Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
RA   Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
RA   Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
RA   Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
RA   Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
RA   Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
RA   Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
RA   Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
RA   Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
RA   Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
RA   Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
RA   Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
RA   Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
RA   Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
RA   Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
RA   Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
RA   Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
RA   Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
RA   Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
RA   Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
RA   Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
RA   McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
RA   Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
RA   Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
RA   Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
RA   Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
RA   Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
RA   Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
RA   Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
RA   Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
RA   Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
RA   Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
RA   Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
RA   Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
RA   Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
RA   Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
RA   Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
RA   Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
RA   Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
RA   Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
RA   An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
RA   Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
RA   Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
RA   Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
RA   Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
RA   DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
RA   Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
RA   Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
RA   LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
RA   Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
RA   Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
RA   Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
RA   Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
RA   Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
RA   Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
RA   Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
RA   Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
RA   Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
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DR   EMBL; CH480820; EDW54099.1; -; Genomic_DNA.
DR   RefSeq; XP_002037681.1; XM_002037645.1.
DR   ProteinModelPortal; B4I2V4; -.
DR   EnsemblMetazoa; FBtr0201378; FBpp0199870; FBgn0173300.
DR   GeneID; 6613200; -.
DR   KEGG; dse:Dsec_GM18393; -.
DR   FlyBase; FBgn0173300; Dsec\GM18393.
DR   KO; K00665; -.
DR   OMA; CHAEGTL; -.
DR   OrthoDB; EOG091G003K; -.
DR   PhylomeDB; B4I2V4; -.
DR   Proteomes; UP000001292; Unassembled WGS sequence.
DR   GO; GO:0004312; F:fatty acid synthase activity; IEA:EnsemblMetazoa.
DR   GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0071329; P:cellular response to sucrose stimulus; IEA:EnsemblMetazoa.
DR   GO; GO:0005977; P:glycogen metabolic process; IEA:EnsemblMetazoa.
DR   GO; GO:0019432; P:triglyceride biosynthetic process; IEA:EnsemblMetazoa.
DR   Gene3D; 1.10.1200.10; -; 1.
DR   Gene3D; 1.10.1470.20; -; 1.
DR   Gene3D; 3.40.366.10; -; 2.
DR   Gene3D; 3.40.47.10; -; 2.
DR   Gene3D; 3.40.50.1820; -; 2.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR013149; ADH_C.
DR   InterPro; IPR023102; Fatty_acid_synthase_dom_2.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR032821; KAsynt_C_assoc.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020801; PKS_acyl_transferase.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR020807; PKS_dehydratase.
DR   InterPro; IPR020843; PKS_ER.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR001031; Thioesterase.
DR   InterPro; IPR016039; Thiolase-like.
DR   Pfam; PF00698; Acyl_transf_1; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   Pfam; PF16197; KAsynt_C_assoc; 2.
DR   Pfam; PF00109; ketoacyl-synt; 2.
DR   Pfam; PF02801; Ketoacyl-synt_C; 2.
DR   Pfam; PF08659; KR; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   Pfam; PF14765; PS-DH; 1.
DR   Pfam; PF00975; Thioesterase; 1.
DR   SMART; SM00827; PKS_AT; 1.
DR   SMART; SM00826; PKS_DH; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SMART; SM00825; PKS_KS; 2.
DR   SMART; SM00823; PKS_PP; 1.
DR   SUPFAM; SSF47336; SSF47336; 1.
DR   SUPFAM; SSF50129; SSF50129; 1.
DR   SUPFAM; SSF51735; SSF51735; 2.
DR   SUPFAM; SSF52151; SSF52151; 3.
DR   SUPFAM; SSF53474; SSF53474; 1.
DR   SUPFAM; SSF53901; SSF53901; 4.
DR   SUPFAM; SSF55048; SSF55048; 1.
DR   PROSITE; PS00606; B_KETOACYL_SYNTHASE; 2.
DR   PROSITE; PS50075; CARRIER; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001292};
KW   Phosphopantetheine {ECO:0000256|PROSITE-ProRule:PRU00258};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001292};
KW   Transferase {ECO:0000256|SAAS:SAAS01038082}.
FT   DOMAIN     2697   2774       Carrier. {ECO:0000259|PROSITE:PS50075}.
FT   MOD_RES    2732   2732       O-(pantetheine 4'-phosphoryl)serine.
FT                                {ECO:0000256|PROSITE-ProRule:PRU00258}.
SQ   SEQUENCE   3089 AA;  338196 MW;  5F2707443F4E8543 CRC64;
     MPSRKKAQAD SAAGEDGDIV ISGLSGKLPE SSNIEEFKYN LLNGIDMVTD EPRRWEAGIY
     GLPERMAKMK DSDLEKFDDK FFSVHQKQAE LMDPCMRMLL ELTHEAIIDA GINPAQLRGS
     RTGVYIGLSF VETEHEIPNM EPSSINGYCL TGCARAMFAN RISYTFDFKG PSFIVDTACS
     SSLVALNHAF ADMRAGRCDY ALVAGVNLIL KPIFALQFLR LGIVSHDGAC KTFDAAANGY
     ARADTCAVVL LQRRKVAKRV YASILNVRTN TDGFKEQGVT FPDGRMQQAL LEETYSEIGL
     NPDEVVYVEA HGSGTPVGDD QEANMLSNFF CRPSRHTPLL IGSVKSNMGH AEPASGVSAL
     AKMIIAMEEG IIPKNLHYRT PNPSVPALVE GKLKVVDRNL PWQGGIVGLN SFGFGGANAH
     VVLKSHTKAK EPKACPKAGE AEQSLRLVTS SGRTDDAVHQ LLKVATEQRH DQELLTLIND
     IHSHPIPLHP FRGYAVLGTS GCVKEEVLPY EEEERPIWFV YAGMGSQWAS MANDLMQLDV
     FRNSIQHCAE PLQLKLLQAV DQPHPVAFKP NNCSNHLPQH SPSTQNNGKS ARANRRRRRR
     RNKQQQNSQQ PDAFRDTDAQ LTPSTSSSTP HSAPNDRQDH LNSQFNPKPI NMPARFAEEV
     ITAEPAQRAA PQLDLGGGHY VPRQQHLNDE IAITGFSGRL PESSTIEEFK QNLFDGVDMV
     NDDPRRWERG LYGLPDRIGK LKESDLENFD QQFFGVHQKQ AECMDPLLRM LLELTHEAII
     DAGLNPSDLR GSRTGVYIGV SNSETEQHWC SDADRVNGYG LTGCARAMFA NRISFTFDFK
     GPSYSIDTAC SSSLYALEQA FSDMREGKVD NALVAGAGLI LKPTMSLQFK RLNMLSPDGS
     CKAFDESGNG YVRSDGCVVL LLQRTSAARR VYASILNVRT NTDGFKEQGI TYPIGKMQNR
     LIRETYEEIG LNPADVVYVE AHGTGTKVGD PQEVNSITDF FCKDRTTPLL IGSVKSNMGH
     SEPASGVCSV AKILIAMEEG VIPGNLHYNK PNPDLYGLVD GRLKVVDRNL PWNGGIIGLN
     SFGFGGANAH VILKSNPKPK ALTPKDGALK VVLASGRTFE AVEQLLESAS TNADDDEYLQ
     LINEIHSKAI PNHFFRGYGV VSSKGTHQRE VIESNDDKRP IWYIYSGMGS QWASMAKDLM
     QIEAFAKTIQ RCADVLKPEG VDLIDVLTRS TDKSFENILN SFISIAAMQV ALTDLLSSLG
     IHPDGIVGHS VGELGCAYAD GCFTPEQTVL AAYWRGKSIL DTQLAKGKMA AVGLSWEDAH
     SRVPSDCFPV CHNSEDNCTI SGPEASIEAL VAKLNAEGVF AKAVNSSGYA FHSKYIAEAG
     PKLRKSLEKI IPNAKNRTAR WISTSIPESA WNTPVAKQSS AAYHVNNLLS PVLFHEALQH
     VPKNAISVEI APHGLLQAIL KRALGPDATN LSLVKRGHEN NVEFFLTNVG KLFAAGAQPQ
     VLTLVRPISY PVGRGTPMLN SKVGWDHTQK WLVAKFGKET SSGETIVEVD LSKEDDAFLA
     GHTIDGRILF PATGYMTLAW QTFAKMQGSE FHKTPVVMEN LVFHRATILN KNAVVKFGIN
     FFDGTGAFEI CESGSLAVSG KITIPESIDN EELPLEEQTP SAVAKELGTN DVYKELRLRG
     YDYAGIFRGI VRSDTVASTG KLQWVDNWIS FMDTMLQFSI LSKNLRELYL PTRIERAVIN
     PAKHFELLSA LTKEEQVETG LPVQWYSDIN VIKSAGVELR GLKANLAQRR PGTQAPPTLE
     RYQFVPNINT TDLNENSEKA RLHALDVAIQ VIIENSSGAV KLKGVELANG RNPDVLVANR
     LLQIIEGEPV LTGDVAVVTS NNNEETITAA LGDSGVRVVS KDVLKEPVEQ NCHFVFGIDV
     LSRPDTKTLE NSIASIRENG FLILEETLPT YTKTGRALLT KFGFVAVQEQ SLGVTRVLVL
     ARKAVDLKTR KSVVVVATEQ NFNWVDDLKA ALATAATEEQ YVYVVCQGEE LFGAVGLMTC
     IKNENGGKLA RLVFVQDAKA EKFSLTSTLY RQQLEKDLIS NVLKNGAWGT FRHLKLETQQ
     ATLQVEHAYV NALVKGDLAS LKWIEAAQAD TAATVDKNLE TCTVYYAPIN FRDVMLTSGK
     LAADALPGDL AEQDCVLGLE FAGRDTQGRR VMAMVPAKSL ATTCVASKRM MWQIPEKWTM
     EEASTVPCVY STVYYALVVR GQMKKGEKIL IHAGSGGVGQ AAISVALAHG LTVFTTVGSK
     EKREFLLKRF PKLQERNIGN SRDTSFEQLV LRETKGRGVD LVLNSLSEEK LQASIRCLGL
     NGRFLEIGKF DLSNNSPLGM SVFLKNTSFH GILLDSVMEG EEEMQNQVVS LVAEGIKTGA
     VVPLPTSVFN DQQVEQAFRF MASGKHIGKV VIKVRDEEAG KKALQPKPRL INAIPRTYMH
     PEKSYILVGG LGGFGLELTN WLVTRGARYI VLTSRSGVKT GYQGLMIRRW QERGVKVVID
     TSDVTTAAGA KKLLENSNKL ALVGGIFNLA AVLRDALIED QTAKDFKTVA DPKVTATKYL
     DQFSRAICTE LDYFICFSSV SCGRGNIGQT NYGLANSAME RICEQRQVSG FPGTAIQWGA
     IGDTGLVLEN LGDNDTVIGG TLPQRMPSCL QTIDLFLQQP HPVVASMVVA EKRKSDQSAG
     VSLIATIANI LGLRDTKNIQ DGASLADLGM DSLMSAEIKQ TLERNFDIVL SAQEIRQLTF
     GALKAMDGGA DVKPAAAAPA AAAGVPEANI TSVGSSRTAS PLGDGTQVVF TTSLIPTEAI
     VQLDTKAPAN SKQSPIFFIS PIEGFASALE PLAKRLEVPA YGLQFTEAVP SDSLESAAKF
     FIKQLRTVQP KGPYKLAGYS FGCLLTYVMA GILEETNEVA NVIMLDGAPS YVNWYTSSFK
     QRYTDGTNAD NDNQSYGLAY FGIVLANIDY KALVRLLIVI PTWEEKLERF AELMSNEITQ
     PVETIKKSAT LFYKKLELAD GYQPTLKLKT NVTLVKPTDN SAKLDEDYRL KEVCTKPVEV
     HTVEGNHRTF LIEDQSLKTI QSILKRLFN
//
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