ID B4IXW8_DROGR Unreviewed; 2634 AA.
AC B4IXW8;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=GH16271 {ECO:0000313|EMBL:EDV96489.1};
GN Name=Dgri\GH16271 {ECO:0000313|EMBL:EDV96489.1};
GN ORFNames=Dgri_GH16271 {ECO:0000313|EMBL:EDV96489.1};
OS Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Hawaiian Drosophila.
OX NCBI_TaxID=7222 {ECO:0000313|Proteomes:UP000001070};
RN [1] {ECO:0000313|EMBL:EDV96489.1, ECO:0000313|Proteomes:UP000001070}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15287-2541.00 {ECO:0000313|Proteomes:UP000001070};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; CH916366; EDV96489.1; -; Genomic_DNA.
DR RefSeq; XP_001984141.1; XM_001984105.1.
DR MEROPS; S01.013; -.
DR EnsemblMetazoa; FBtr0461058; FBpp0411470; FBgn0123742.
DR GeneID; 6557583; -.
DR KEGG; dgr:6557583; -.
DR eggNOG; KOG3627; Eukaryota.
DR HOGENOM; CLU_228608_0_0_1; -.
DR InParanoid; B4IXW8; -.
DR OMA; DCMSAFL; -.
DR OrthoDB; 3035825at2759; -.
DR PhylomeDB; B4IXW8; -.
DR Proteomes; UP000001070; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0098595; C:perivitelline space; IEA:EnsemblMetazoa.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:EnsemblMetazoa.
DR GO; GO:0009950; P:dorsal/ventral axis specification; IEA:EnsemblMetazoa.
DR GO; GO:0007343; P:egg activation; IEA:EnsemblMetazoa.
DR GO; GO:0007306; P:egg chorion assembly; IEA:EnsemblMetazoa.
DR GO; GO:0016540; P:protein autoprocessing; IEA:EnsemblMetazoa.
DR GO; GO:0160032; P:Toll receptor ligand protein activation cascade; IEA:EnsemblMetazoa.
DR GO; GO:0031638; P:zymogen activation; IEA:EnsemblMetazoa.
DR CDD; cd00112; LDLa; 9.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 7.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 3.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR015420; Peptidase_S1A_nudel.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR033116; TRYPSIN_SER.
DR PANTHER; PTHR24252; ACROSIN-RELATED; 1.
DR PANTHER; PTHR24252:SF7; HYALIN; 1.
DR Pfam; PF09342; DUF1986; 1.
DR Pfam; PF00057; Ldl_recept_a; 2.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00192; LDLa; 9.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 7.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 2.
DR PROSITE; PS01209; LDLRA_1; 2.
DR PROSITE; PS50068; LDLRA_2; 8.
DR PROSITE; PS50240; TRYPSIN_DOM; 2.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Hydrolase {ECO:0000256|RuleBase:RU363034};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Protease {ECO:0000256|RuleBase:RU363034};
KW Reference proteome {ECO:0000313|Proteomes:UP000001070};
KW Serine protease {ECO:0000256|RuleBase:RU363034};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1154..1392
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT DOMAIN 2045..2315
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT REGION 201..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 550..581
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 847..881
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1123..1147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1452..1490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1523..1579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1672..1724
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..219
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 550..576
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1132..1147
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 926..941
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1003..1018
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1405..1417
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1424..1439
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1777..1792
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1815..1830
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2333..2351
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 2460..2475
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 2634 AA; 292859 MW; 0F95A24AED984D66 CRC64;
MRFHRIPRRN CFPRLPCTRI LIISVLVLIT LLVSLIYHGI VLERMDHLRQ LMALNRKHAR
HMQPFNENDA FVISPQPQPF RIQLMNDDAT MAVATKSEEK ALRLKHLRFK FRMKRRFRPR
RSIQSVDLLD PLQLELKMQH LYTKLRNKRA KAALSQLENE YVRCKVQTPE DCMLAFMRMY
KMAKEITEKM DKMKEIIKDH LESSSMESQD SESDAPAKTK TKKTTVPPLE ELTTSTSSDE
ETTLKPTRVK ITPAKISWII DGHGHDEQEA YVENTPRALT TTELDYGTTT TLATTTVEST
TLTTTVESST FTTTAESTTA TTTVGNTTPT TTVDSTIPTT TTVSTATSSS NSNSSFTATT
TTGNHLLVHT TEGPDVDDII DPITWFLDRF DKPKEIRRTT VPTNEKATTI EITTEVQQTT
TLPSFDFKSG PLHSDDHMTN ASFHSTTTEL TTDAPAPLTT TTNTAESETL PRKLQHDWIL
DVEEQEVEPI VHPVTTPPII STTFSPSTST DVVDAANQTA IPTKLKPIKF SWIIDGDDGS
IEERITTQVA GTTETSTDTR TETTIESTTE SARAMHPLDN PSSIENMLDS SERHGQEKPL
IKVLPAKNET TLPENSKNDS VYDRNHWLHQ FEQQASQDEL IETFGTEQDV KSLQQLGPKL
NPASGKQLNA ADAQLMTICA HISRKLRQQA ASEVASTESD TFTASPSVQF TSRAPGGFPV
SGETMKASAQ FMFNPNFGMP SIPVCFYMTP ANFRMPMWSP TPTFMGMQAG HFGGSSNAGG
IFFVPQQTFG PSANFFGGSG GTAGGGGAQN QLPNIFSKNA SPLKQGGNGQ QQQVYCTYMQ
NQQGHAQSQG QSIQGNLSPG SQAGFSNANF KMRHGANQTS GPQQSQIIYA SYVGEPQQPL
ERFKCPEADQ SACYGQKQCI PTSRWCDNVV DCSDGSDESA CTCADRLDED RLCDGYADCP
MGEDELGCFG CESLAHSCYE NAEEYARHNR SKLSMCYSRL ERCDGFRNCF NGRDELQCSM
LITDVTHHMS HAATSSEGYL FHNHRGDWYP VCNNGAKWAS DACELQELNQ TTNVTFKELT
LTGPFIEPSL HAGIHFAQAC HGRNDQDTLV NHVAYVKCPS PQCGLPSKPS QSENKKRTRR
APIEDRTDAA KTRIVGGSYA TQLQWPFVVA IYRDGNFHCG GTIYSEHWII SAAHCVINFG
KYYYEVRAGL LRRTSYSPAT QIQTVSHVVV HQAYERRTMR NDLSLVRVAA PLQFNRWVKP
ICMPDMGRTT FGQDWIWGPE EHTLCTVVGW GAIREKGPSS DPMRQVILPI RKGCTDPEDR
ASEDVCAGEP DGGRDACQGD SGGPLFCRSV SQPDQWYLAG VVSHGNGCAR PKEFGVYTRV
ALYLDWLELA VEPHLLPARQ PLQLCPGFLC VWGGKRCIAQ RKRCDRNVDC LGGEDEVGCA
YNFIPDMVGT SKQNISSTTE SDYHPPTIRK NVPQDQEAQQ TESKQRQDVS LEDANLSAEI
MKVPPAESET GQINATTIIA TTESDDLKTT GENSKEITQT ETELELTTAT SSETTTTLQK
DSLQTTTTGP STLPTTWPTS TEDFMKLTDL INQLLEESTT IATTSGEGLA NTTLFTFTTD
APSLATTTIT TLATVAETTT TDVETTTFMT PTTGDNTTTD SVKTTITLPT TTTLPTAKAP
TTTTTTMQTT TTRTTTTPPT TTTPPTTTTR TNSIPTTKSS KGISKPQLPD KFICQKMPQI
VDMLHRCDRN VDCEDGTDEL DCTCREYLKG RLSVLICDGK ADCEDLSDEK DCGGCQENEY
HCALSKTCLP LAKRCDNIVD CKFNEDEKDC FALTNGHDVH FDAHQQPKFS SVGIFSKNAH
GLWRVVCAHE TGFHEHQAKT ADTVCALLGF KGAHHYNSTE FVNQQEMHPI TPELAKKSQS
GSELQTLMRD NGQLSSGERR LPLDIPHMLL GQHKAHVLAD KCVGIYVECN PRSNATLPMK
TFSAGQPIKH RPSEHLPELL PTIETHKRPN VHFKPQLPAQ LVNKKDEIMD RLDMLIKSKN
NKTLLVQDQL HEAIEDLHWP WLADVYANGE LWCLGVLLDK HWLLVHESCL SGISFETHYI
STLLGGGKTK HSLHRSTHEQ VRRVDCFEAV PKSNVLLYHL EQPARFTHYV LPTFLPDISS
EKESPPHECI GVLQDDYTGR IKTVAITEIK NDTSCISCYQ LQQRQPSGNL MRMLNVSAED
MASISEEVEL VSGVTAREMP ALTKFTSCTQ FGQKNHTDAQ VSPSNQGVLV CRDSHTGWFP
TALFSYNNTN CQSFNTPFGI RTLEQAYKSL QDIMDQPHCS NVQSMPPCTT HRCPLGTCLE
QTALCDGHSD CHDGSDEVES KCRELKQRCA PGEMKCRTSS KCVAKSKFCD HVPDCEDMTD
EPTICSCFTY LQATDPSKIC DGKRNCWDKS DESSVLCNCT ADHFQCSSSP EDCIPRDFVC
DKQPDCPNGE DERFCFGIEQ PLHEQQDDYW SHSGHSHKAT VSKYGQVIEQ SYGIWHTKCF
PKSSPPSVAE VRDICKKLGY HPDRMPSYRL IDDTTNEAKH TFEVADHLGR SFSNDSLVGK
YRESTKAVII SKFSPLELNE RLTLFLKPSR SIAELVRWNT TDSNRCFRLE IRCA
//
