ID B4JTJ9_DROGR Unreviewed; 2277 AA.
AC B4JTJ9;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 24-JAN-2024, entry version 79.
DE SubName: Full=GH21878 {ECO:0000313|EMBL:EDV95089.1};
GN Name=Dgri\GH21878 {ECO:0000313|EMBL:EDV95089.1};
GN ORFNames=Dgri_GH21878 {ECO:0000313|EMBL:EDV95089.1};
OS Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Hawaiian Drosophila.
OX NCBI_TaxID=7222 {ECO:0000313|Proteomes:UP000001070};
RN [1] {ECO:0000313|EMBL:EDV95089.1, ECO:0000313|Proteomes:UP000001070}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15287-2541.00 {ECO:0000313|Proteomes:UP000001070};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
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DR EMBL; CH916373; EDV95089.1; -; Genomic_DNA.
DR RefSeq; XP_001994353.1; XM_001994317.1.
DR STRING; 7222.B4JTJ9; -.
DR EnsemblMetazoa; FBtr0461243; FBpp0411647; FBgn0129339.
DR GeneID; 6567411; -.
DR KEGG; dgr:6567411; -.
DR eggNOG; KOG1811; Eukaryota.
DR HOGENOM; CLU_230725_0_0_1; -.
DR InParanoid; B4JTJ9; -.
DR OMA; SYYTALC; -.
DR OrthoDB; 2945465at2759; -.
DR PhylomeDB; B4JTJ9; -.
DR Proteomes; UP000001070; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:InterPro.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR GO; GO:0000281; P:mitotic cytokinesis; IEA:InterPro.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR028730; ZFYVE26.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46591; ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 26; 1.
DR PANTHER; PTHR46591:SF1; ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 26; 1.
DR Pfam; PF01363; FYVE; 1.
DR SMART; SM00064; FYVE; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001070};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 1467..1523
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT REGION 397..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 521..558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 521..539
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2277 AA; 259216 MW; 7DC3E472A34C650D CRC64;
MAAIQQQKQQ DLQQLIELLP IEENQFIQSF IECLDGIVTP AYWEHLQALI IASPYPTLQI
LQILYNRSKF HFGRIVSNAL NQMLDDDDAL NSSSGTSRFL SVLANFPQQI LEVATVQKKL
IERLESDSWV NNEHLMLALL ARQDSQLLKT ILYKQQQQQE ILCSNAAPTR QLVLQLALSQ
REHFVPRVCQ QLKNFECIHD CTLRNNLLIL RLANEFAIGT QTLDELAQLD QVLAVFDIAA
VPADVQPVQQ FFYADFQRLA VLLKFLQQQQ EGNACKTIKV DALLRAPGML SLIYEHGIQC
DNEQVVQLIE DAYKWQQQTP ALKCVRAEEL ETWSYYTALC HVYNVILELH DSSIREQLLL
LSAQLRQLRE LGTLCSLLQD IFQLVFLRWE QLQNTKECDG DDDDDEQYVD DDATPPRPAN
VPSAQKRRYG FICRAPVLYA LFSYLKSFVT KKLHTQDFKY ATEEQQRCFQ RLVDAISEAL
WKFSVLQKIE QSLTKATASA SGCNLEPEQL LQLIQLHSHA REKASSDDES RERSYHASSL
TRRKSRRQRR AVSFSGAAAS KSADAPTLEQ CRARAQQLLL HGSRRNREPQ LAVSQPTDRS
IIPKMLSTPE QLAIMALALK NFNDVKYIIE TFHLEQSQLS RELQFMEHQQ LIKQKLANIY
ANYEKLTGEA NDTKSSSTTT TTVEQIKSVA AKGFELSKII SVVDNFAQSQ KLQHSAELRS
LLQRHSANAQ NGFLQQFQER NLNALIVCDL IVNLSFNREI TCNLLLVIRR QQQQQQQQQQ
QQQSAGDSSN DGRPREIGAM YLMENLCECM RLLERAGRQP ALNALLCRHS YALRPAPLAL
QLQREAAFTT LYQKASMDYA HSRELRGHAS LFQQFKSRYN YYTRFCGYMQ QLARLLQLRD
PNLEYHNTQL LRHDPYQVIG ELIYDCNITP LEIEGNVAAL HLNLVHVIAL NICPQLAERT
VKQSPRSVPV QKQESIHNYI AQHNQLLAQL LQAIQLGDLP PTDISETGLN FSCLRQLMQL
PEMATLALMH EKNAVMAALH AYKLDSANLE RLDLSKELQF RILLLGIGGQ GESTTQLKTR
IDRLISELIA EDPKHIQLAS HMNDLGTRAQ LLQQHFTKIS SSQLAKELIE RTLQHRGAEI
AIPQLLRSQL EHTLSDITIY ARVSALLQFE SWPQAYDFGR QTPNVIFEKL LQGRHYELCH
EWCRMVQLTD SAGQQRVCLL TLLDALLELR DEDELDPHLL HIAELFPAKV LVNFLDTHKD
KMRSLALLQW LVDYLERHAR NARPYLNYQL SLELLRQLPS AQREHFWALL HYPLLIIEQL
VMNTRFELLT KLLEPARAKL QQRIPLGPCG YCFEKRGHAY DVHSSSSSTD KGTGKLKFQL
GHSNTEAFIL LNFNSYQQDH VISNDCLDLL LRIYASNALD YQIANVRTGL APEPGSLGTD
VQNSLDSLCG AFQMPKQAPS REQWTPDEEA THCMCCRRSA FTMLMRRHHC RRCGRVVCYA
CSAQRMVIPE LYGDVEVRVC NDCCVPVAAE KPLHVNETAT IVARAPSNPS DSYKWRLSGI
ITHDKLLREE FCYEHAPSVA LSLSILRHHL DQRQCVDLLL FHCRKLEKLI VPNPEVDYQL
VAKMMNCLAL AAKVRGAPGE FENIREHSEI IMAVVQQGCE SLIPAGSLNN HSMRKLADAL
VEAEHWKLAL EVHLKWGFAT TGVMAAHGLA CLRAGCYDAA REKFGHCMAR LSTEEQNSHI
YKEIFDKDLP ALVSQTDTPT HMPKKRPQRG PALLQEILQL IAAMPQAQPQ PETLQRASLI
RNSNTSLASL FSRRREPYVV QTPLQEPALN VINALANLKH IAKGHYGEAT MKCGTEENRQ
TRSFEESLHY VLTYGSHTDI LQFLMQHDEL RAALRYWLHQ QLEAELFILH IFHVSLAGGR
LPALIDELLQ LDTDAQLNSW RVPLLQTCRF LEQQQQLNSL YQLQLLLKDP VRASMTCVKF
YSLHCENFQK LHANAQHLVS AHMHLQSELD LAEWDHLQRE QKQSGSRRVS VASFNASTTC
FAMQLDARAL NGHINTIRRQ MELAKFLAQC EREQASVSGS LCTLQILKQI RLEAPRGTLP
TLFDGAADKI QLCILVLLCG KNIDEGFGLA YGIMQDYKLA PMKVFGATAK YLAKNERLSE
VDRLLDCIAS NNGSSTASES DELLSIAVNA AVNSNEPETK QTLDKLVKRI GNIELRISSY
IFIGQLKSAY LLANKNERLT DIRKILRQAE MTNQIHIKKL CEKKLNINSS PMSPTPL
//
