ID B4JTR4_DROGR Unreviewed; 1871 AA.
AC B4JTR4;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=GH13772 {ECO:0000313|EMBL:EDV91493.1};
GN Name=Dgri\GH13772 {ECO:0000313|EMBL:EDV91493.1};
GN ORFNames=Dgri_GH13772 {ECO:0000313|EMBL:EDV91493.1};
OS Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Hawaiian Drosophila.
OX NCBI_TaxID=7222 {ECO:0000313|Proteomes:UP000001070};
RN [1] {ECO:0000313|EMBL:EDV91493.1, ECO:0000313|Proteomes:UP000001070}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15287-2541.00 {ECO:0000313|Proteomes:UP000001070};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
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DR EMBL; CH916374; EDV91493.1; -; Genomic_DNA.
DR RefSeq; XP_001994864.1; XM_001994828.1.
DR SMR; B4JTR4; -.
DR STRING; 7222.B4JTR4; -.
DR EnsemblMetazoa; FBtr0464318; FBpp0414612; FBgn0121248.
DR eggNOG; KOG1452; Eukaryota.
DR HOGENOM; CLU_002292_0_0_1; -.
DR InParanoid; B4JTR4; -.
DR OMA; NQHGNHR; -.
DR PhylomeDB; B4JTR4; -.
DR Proteomes; UP000001070; Unassembled WGS sequence.
DR GO; GO:0031594; C:neuromuscular junction; IEA:EnsemblMetazoa.
DR GO; GO:0098831; C:presynaptic active zone cytoplasmic component; IEA:EnsemblMetazoa.
DR GO; GO:0048846; P:axon extension involved in axon guidance; IEA:EnsemblMetazoa.
DR GO; GO:0048789; P:cytoskeletal matrix organization at active zone; IEA:EnsemblMetazoa.
DR GO; GO:0048790; P:maintenance of presynaptic active zone structure; IEA:EnsemblMetazoa.
DR GO; GO:0045467; P:R7 cell development; IEA:EnsemblMetazoa.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR GO; GO:0007416; P:synapse assembly; IEA:EnsemblMetazoa.
DR GO; GO:0097479; P:synaptic vesicle localization; IEA:EnsemblMetazoa.
DR CDD; cd00030; C2; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd04379; RhoGAP_SYD1; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR46150; RHO GTPASE-ACTIVATING PROTEIN 100F; 1.
DR PANTHER; PTHR46150:SF3; RHO GTPASE-ACTIVATING PROTEIN 100F; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001070}.
FT DOMAIN 168..238
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 774..897
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 937..1137
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 252..325
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 481..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 730..758
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1139..1201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1282..1482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1496..1610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1645..1670
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1692..1711
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1772..1795
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1812..1871
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..86
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..313
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 496..515
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 734..758
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1139..1167
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1296..1327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1390..1482
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1539..1610
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1829..1843
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1844..1861
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1871 AA; 199669 MW; 6CE87A592D1B0183 CRC64;
MCERATTGCF LTRSSGRKEN GRSVPDVTAS PGRAPPGPLP ANQISGMVNQ QQQHHHANQQ
QQQQQHHGNQ QQNRGQNQNT NGSGGVKDPV LLQGDFRKVS GISSEIFRQI EAVENDHDPN
TAAALEAVER RGEMIVRILE PRSMGSKHAV DAAHKLMNKA DGRHTVQLVE IVKRPGQTLG
LYIREGNGAD RTDGVFISRI ALESAVYNSG CLRVGDEILA VNLVDVTHMS LDDVVIIMSI
PRRLVLAIRQ RRGNRGAGSP GPPTLSRPEQ KPPPVVVIKR DLRDEDLDET DRMPRPRSSR
ERRTGDGREM TESRSRLGLG LNNYSPQSEQ LDMYYNTRAG VNAMGEPPNW GYKPPPPPSS
VITEQPTKGH AFAPSHAYYQ NAGTLESLAE KVHAFYPGAP GQPLGPSRRM STGTGNVGLA
QQHARFPRSG SDQHLPRVEY ADYSNSLGRH SLLRSSLKPG TAAPMPVGVG GTLGRYGRYE
QQRGGVPKYG PSPAGAQSLT RRSRPNLDYS SDTEATIGPR PSYYYYNRPA IGSMPRASGV
SGGAAAAAAA MLAGATDLNK FNSLPRERPG VRLQGIRARI GDRILDENDG NISAPEYDAR
RGRDLRQRIT ASPGPSIFTA DEYRAWLRRA PSSSAIAEQM RMTRDMFAQP RSHRFSCSAE
NIHDALRNTE SIYSSRTGIL GAGTLDRNLG LTRPISALPV RSMSSQHIGG AGSIRSPSIR
RMRQLLELSA GPASPSGSIM STAGHQSPAP TPSATLPRQH RQIDINPAEF AKYKLDKPIV
DIGGVSGMLW IHLLAGRGLR TAPEMGAQHA GGGAPPQLTR DLYCVIECDR VHKARTVVRS
GDLQFDWDES FELDLVGNKQ LDVLVYSWDP QHRHKLCYRG AISLSAVLRQ SPLHQLALKV
EPRGTVYIRM RHTDPLALYK RRGLPSLRAG YPTLFGADLE TVVNRESKNV PGCAPVPIVL
RRCVEEVERR GLDIIGLYRL CGSATKKRLL REAFERNSRA VELSPEHVPD INVITGVLKD
YLRELPEPLF TRCLFQMTVD ALAVCLPDDP EGNAKLMLSI LDCLPRANRA TLVFLLDHLS
LVVSNAERNK MSAQALATVM GPPLMLHSAS AQPGADIDHA QPIAVLKYLL QIWPQPQQQQ
HQQQQQHQQQ HLQQQQQQHT QHQQLAQHMG GMAAASSMSN MAGVASGRRG ESTGQRGSKV
SALPVDRQQL LLQQQQQLMA AGNLLRSSTS VTNILSQGHH QLSATANSHL YQSVVGQLAQ
SHRALQQAVQ QPYQLAGSAV SAIPDQSPLP LPGTPSPGSS SASTGSGSGS GSGSGSGKST
DTIKRGASPA SVKQVKIVDT PSPYSVVQKK PPLQKDVPIE ETTPPEANAS SSIRKGVDFY
EPLKPHSKSL TGDESYSSKY SSSILDTKKS SYSSSYTPGK SFNASSGTST VTASTTDDYK
AMRNKSSATS SSSSSQATVL SAGSTATSAP TTSSDDSDDL VSYKSSASTN ALLAQSQAMT
TSQLMSKYLK REPRVQFTPI KSPESPSPPG GSDGLPKGTY QLVTPSSSST CLAKPSATTG
AISKYTTSTS SPSTADTSTN LTSSNKLSSS PARQTNNGKS SGAVSSSSSL VSSGRRLFDS
LASSSSSETE TKTYIGGTTV ASAASTTTTY TNESRNVASN SSSSSIKAAS GSEHRSFGST
LFGSSAIGNG NGHVSHSSNS PFASTNGNAN GGSSNHSAMN LYGTLPKNGA GSGSSAGATL
FGASASSSYH SGGGTASSSG VSSMTGSTNS YDFYSSSSSG GSSSRPFANG GNNYHTLGTY
RAQYAATNPF LDAFDEKPSS NGGNNGHSSH HAADDKHVSN PEKSHQRASM VASFQASGDS
KNGSDEYDDL K
//
