ID PESC_DROGR Reviewed; 635 AA.
AC B4JZG8;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Pescadillo homolog {ECO:0000255|HAMAP-Rule:MF_03028};
GN ORFNames=GH25074;
OS Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Hawaiian Drosophila.
OX NCBI_TaxID=7222;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15287-2541.00;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Required for maturation of ribosomal RNAs and formation of
CC the large ribosomal subunit. {ECO:0000255|HAMAP-Rule:MF_03028}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-
CC Rule:MF_03028}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03028}.
CC -!- SIMILARITY: Belongs to the pescadillo family. {ECO:0000255|HAMAP-
CC Rule:MF_03028}.
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DR EMBL; CH916379; EDV94090.1; -; Genomic_DNA.
DR RefSeq; XP_001996359.1; XM_001996323.1.
DR AlphaFoldDB; B4JZG8; -.
DR SMR; B4JZG8; -.
DR STRING; 7222.B4JZG8; -.
DR EnsemblMetazoa; FBtr0160488; FBpp0158980; FBgn0132529.
DR GeneID; 6570125; -.
DR KEGG; dgr:6570125; -.
DR eggNOG; KOG2481; Eukaryota.
DR HOGENOM; CLU_019619_0_0_1; -.
DR InParanoid; B4JZG8; -.
DR OMA; QKVTWIV; -.
DR OrthoDB; 169151at2759; -.
DR PhylomeDB; B4JZG8; -.
DR Proteomes; UP000001070; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; ISS:UniProtKB.
DR GO; GO:0030687; C:preribosome, large subunit precursor; IEA:UniProtKB-UniRule.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000466; P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:UniProtKB-UniRule.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ISS:UniProtKB.
DR CDD; cd17709; BRCT_pescadillo_like; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR HAMAP; MF_03028; Pescadillo; 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR010613; PES.
DR PANTHER; PTHR12221; PESCADILLO - RELATED; 1.
DR PANTHER; PTHR12221:SF6; PESCADILLO HOMOLOG; 1.
DR Pfam; PF16589; BRCT_2; 1.
DR Pfam; PF06732; Pescadillo_N; 1.
DR SMART; SM00292; BRCT; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR PROSITE; PS50172; BRCT; 1.
PE 3: Inferred from homology;
KW Coiled coil; Nucleus; Phosphoprotein; Reference proteome;
KW Ribosome biogenesis; rRNA processing.
FT CHAIN 1..635
FT /note="Pescadillo homolog"
FT /id="PRO_0000370454"
FT DOMAIN 321..414
FT /note="BRCT"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT REGION 437..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 489..561
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 600..619
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 596..628
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03028"
FT COMPBIAS 437..452
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..472
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 501..530
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 453
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
FT MOD_RES 457
FT /note="Phosphoserine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 635 AA; 74657 MW; 75344A46158CC821 CRC64;
MRRPKKYESG EATQYISRRA ALRKLQLSLN DFRRLCILKG VYPREPKHRR RAQKGSSEIK
ILYHTKDIRF LLHEPIVWTL RDYKIFAKKS GRDRAIKDFR NLKRRLALFP EIKLDHIVKE
RYPTFIDALK DLDDCLTLLF LFSTFPSLHL IPREQSNLCR RLTIEFLHYV IASKSLRKVF
ISIKGYYFQA EIKGQKINWI VPHYYPFKPQ SRQEVDFKVM SIFVEFYTIM LGFTNFRLYH
GLNLAYPPQF PSGVLQDNDE TLKDESSFVS ERIAALNFEL LRTDKLQEDE EEPDIDMELL
EQDGDSKRII KMKQDAQEIT RLRTLFKGLK FFINREVPRE PLVIIIRSFG GKVSWDSTVF
SGSTYDEGDE SITHQIVDRP SLATQYISRD YIQPQWIFDC VNQRQLLPTN QYFIGEKLPP
HLSPFVDAKR DTYIPPEERA LHDPSLIETH AQSDDESEEE TAAQEEEEDA VEQELLDAQL
QRAYQEETAE YKKYGGADGV NEDEEDSDDE QLYEDEDESD DDEEEELDEK AQRLLEEKQK
MSVQSGKVHK VNKRQVHKAE VDEHRLQARM VKPRHRNLFR KLIREKQSKE KEEWLLRKKR
RNIDTDAKEQ KKTAKRDARK AAAAAAAAAA QLGAK
//
