ID B4JZS2_DROGR Unreviewed; 3504 AA.
AC B4JZS2;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 24-JAN-2024, entry version 77.
DE SubName: Full=GH23949 {ECO:0000313|EMBL:EDV90938.1};
GN Name=Dgri\GH23949 {ECO:0000313|EMBL:EDV90938.1};
GN ORFNames=Dgri_GH23949 {ECO:0000313|EMBL:EDV90938.1};
OS Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Hawaiian Drosophila.
OX NCBI_TaxID=7222 {ECO:0000313|Proteomes:UP000001070};
RN [1] {ECO:0000313|EMBL:EDV90938.1, ECO:0000313|Proteomes:UP000001070}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 15287-2541.00 {ECO:0000313|Proteomes:UP000001070};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; CH916380; EDV90938.1; -; Genomic_DNA.
DR RefSeq; XP_001996526.1; XM_001996490.1.
DR STRING; 7222.B4JZS2; -.
DR EnsemblMetazoa; FBtr0470626; FBpp0420685; FBgn0131406.
DR eggNOG; ENOG502REJ9; Eukaryota.
DR HOGENOM; CLU_224265_0_0_1; -.
DR InParanoid; B4JZS2; -.
DR OMA; YATHHIN; -.
DR PhylomeDB; B4JZS2; -.
DR Proteomes; UP000001070; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR031866; DUF4758.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR PANTHER; PTHR39072:SF2; -; 1.
DR PANTHER; PTHR39072; RE48511P; 1.
DR Pfam; PF15950; DUF4758; 3.
DR Pfam; PF07645; EGF_CA; 1.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00179; EGF_CA; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS50026; EGF_3; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001070};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 3402..3425
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 3311..3350
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3361..3397
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 109..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 690..756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 788..808
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 824..878
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 894..1279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1599..1638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2452..2501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2695..2720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 109..129
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 789..807
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 825..878
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 894..913
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 917..931
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 962..1021
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1033..1047
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1048..1066
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1088..1113
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1114..1152
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1180..1279
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1622..1636
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2472..2501
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 3368..3385
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3387..3396
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 3504 AA; 384209 MW; 72A14BB41A9B0625 CRC64;
MNDEVEVKTT TNTSIEEEEE DNTTVKDMAD MAQTMTKDNN DNCDVLKSQI FLTQLPKLIT
ISNDASEPTI LSSYEVKETT KYYCIQASQV LEYPQLEKPT EVVPVSQNEA TTTEANPKEI
ITTTEENTTT SDIVEDDEDY VTESEREDYE NASDESDIIY KTLYTTYTYL TTFFQADATT
ISSHTEIVTN IITSTLDMEL KSSIISENEI IATTTTKATN LQATKYMIPD DLKELIDANV
NNELKHDSSE SSQKTEYLND VKYTKTFYTT FTYYTTIFAE SETEIMSRTE VFTNYVTELG
APMTSVVQLA KEIVINPTET ESTSNADKLV TLITDVKSSS SNGEQHLKIR DDMADDQISS
ESNTEEMLPS ATLLLQTSFT TFTFYTTMYE QDSTNVVSRL ETVTNIATET LQPTKMPSHA
EDATLPITYF TTFTYWTKLA KDGEITTISR EETISNVIEP TKIWTENSSE TLSKSTTANS
TASSTGSLVN LITQNASDLT TFYTTYTYYT TSYKANQTVT DSRFETIVNV ITPTATIISS
VDSLPVSSIV IDKSELLYYD YKHIIDADGV STLYFTTQIQ SSIDSQGSAI ELTSSTSSLL
VDESKKLELN SVASSSQYKT GLVRLIEGTR VGNRTTTLYQ SKVIGTIIDS RYAQIIESTS
SFLFEKNISP SATIDELIVK STKQLSQLSQ QQIETATVES SMHSEEQHDN DGDGDNDSDG
DSNLSSQSKK RTFAPVIRPF ASRNRPTFAP KQKTLSASSA TIITRSDITP TITATPALKS
VGGARYSSSR RGAISNAPIN PQGAAASSTR RLFGRPLKSS VVAPASAGGL SSSVAGSTTG
FAPSRNRFAS SARSGTASSS RRLSSGSAST SASGYRPASS VNFLNSRQRI RPTAAFGQAL
PASTTTTPAT AAENEPSEED ASTEEETSIA TDDNEEKTAQ NSRRTQNPLL RFRRPLNRPS
GFTPATRVSN TSATNVSVRK NPLASRAKAA TTTTTTTTTV RPRPRSFQRP TLSSLQARAR
PQNNLFPPRG LFQQQREKEK TQAQDNDSDG DADYDDDEDG DEEDQETAQN GTIRRRRRHS
NKKSVTLSRR RRQVDTLSRN RFRFRRPKTA TTEETPAEEQ LAETTTTTRS RLNARFGSRY
KQQSSSTAAT AAHRAIRPTR PTTARAQFTL REKDTAGKSR QAGAGSSAKS NFRRPQSALR
RSGSGSGSSS NSGSNSSSGS SFNSKSANAR RLKNYISSSN NNNNNSRTAS NPRSRTGTGS
GTSSRNRNAN RNRNRNDYNQ DVASAELGSV AITVTHLVPA EVTVPVVNGQ LTEYKNIVTA
KTSLEVLAPH QYTQQVGSNG QTSLYLVRED TSVNAAGVTE LTRYLLHDTL TTTVTFTPTT
IRGRKTSFSH VLPSTVYGVE SVVSTLQPQI AANAPLANIL LSQLLLGNIN LPANPLLGAL
AGTQPALPAL DAAVAATTAA AAVPVTEYRT HTSTYVTTIY DGKSTILPIT FQGKKILTTV
FDTTAQTITA TEYSVDTIVN TPTQQFQQLQ QQSGQVAQVN SLLLQQLLFQ QQQQQQLQPQ
QQQNPAITNT ISPQILLNDN LQDLDEITPY DAPNIEGIIV EQQTTSKSHK KSRKPGKSHK
RHRQHKEEDR EHHTESSVVT LYVSGRRPGE FSTILSTVYS SYEHLTPSTL HKRHAQQTIS
LAEDLYAFEG SERVQSYLPA PVNKNTLGEL DQTASLESII GDVHLWYAKA KATQELSAPS
SSRSNSNLAE LSLDEARFNL ATHVMSNGVE LIIASDKLKH QAAAASASVS ASAVTQFQSQ
SQLPQKPVTL APSTLKNHMI LALPTNNKQT PELVVGTFPT TYHFYNTLRN NGLVLSSTYT
VMNTVTGPED YISYLQPSEE ATPVLDTNTY YSRLAVTRTA PNGILTDSEN VLTQLVITES
KPGRGNPKVK AASSEELDVH IFATKTYLTT VTYLATTSIY HASTDSQGVS NFETKVIVNT
ITDIVPSTLL RPELVSMFRT ELMQKKGKNN RKVLVTLATL LGGQTLQVTA VNLKKTTTNQ
ISSTLIKPTS IKSKPTKTQS KNDELQVDLS VAESQNEPVY VRPLKEVQAT PNPNPTSVEQ
LIGSLNLQRL RPVFDVMADI IQKNIVNRQA TTNLNLRQTS TSTTTENPLE EQPVYIPLEV
SVQQKAAQNR YKSHANKAEI DINRSRLTAH SLHINPPEPA MQIDFNDDDN WLLHNNNMSH
ILSPLSIYPT YPGALLNNGI PIRPGEIINA NADVIIGRPN GILHSPQAQF MNSSPRPKNP
PDYSDRSIAP FKKKTWIPPQ PVPLSLSLTP PRLIPLDYDN ILFPPAQSSS KSQPDFGYIL
TPPGSAPRLP QQQIMHLNAE LNNNEILEIK AIPQIFSTKL PAVTRYPALV AGSSSSYYNQ
RPVNPSVYSD NAGSGSYYSA GPATAAAYAD INGSGGTSFY KQGTAPANTD MGGSSSYYTT
EPAPAPPAYS DMGSRDSSSY YKPGHSYSEK GGSNSNSTPR PSAALLAAPA AYSDMGGSNS
GSYYNPGPTT AAPPAPPAYA THHINLKTSV LNHNINMNVP PLTFKREGDN YPLATAVRGQ
IAPAPMPLIK IPHNKANVEV RLSPQNTRIA VEPPEKLREG QNPNINTFKQ RNQNYLKNTD
NVRSDYVNST LHLAPYQRPT DKYSFINNKN ANQQQYISTI SSDSVQAATN LIRAESSKQS
YASPSTTSNK VPVPDQKTDY TSHSDHNYNL TLSKVNRHIQ NLQLPTSKLT PINPWLSITQ
QTANKTPSLG QPFIKSNQSP ANKPKINIPK KVFVGAGQRF NLLPGLKLET TTTQYIEDLQ
LLTSIRPTNI LEPPPMPINS LHQDVLGMKP PPAIIKNIPN RSSSVVYKIK TSALPATPSI
IISTLQLQLN NSFNTESQIL KPALSSSRFK VLKSQPTFTK TLPKTLSING TSKQQKMTVI
KTEGSFNNVK QHSTQHTNIV NQHSTQQKIN PTKIINQHST QKKINPTNNI KQHSTNLKLS
PTNAINQHST VIKLSPTNIV QQHSTQLQLS PAIEPAVLPT NINSINTKKL NIYQQATLKN
TQIIPNQNQS NLLSLESSEA ETKKIPFSIR SNAPHFDVSF IDRQITKQLY DKSISTLNKN
IATQSVVLKS SSTPIIKSRI IDTKSITFKP IQTHSITKQT ISKTIRKSEN PVKTTSTKIE
QVHSDISNIL VVMKKGTGAD NQNTINLAEE EEELALDYEG NLSLEIPLRD EEIVPPINAN
SILLGGILIA TPSKTNTKSK YTKESSNGVC QPACKANKNE ICSSQPGHGN DNRCECRLGF
ARMFPDRPCK HFDECGNANF NDCSFHAHCF NLIGSYTCSC LDGYVDISDN PIYPGRLCSD
QIVGCELCNY HGNCMAPIVN GTPVCECFSW HSGATCQLNL KILLIGLIAI GTVFILLLVC
MLLIYSRHKV NGACAARPIF ITSSNYHPSM LSTSSNKSLI RDCSMDKHAI LIDTNSESSH
NSEPYSFKVN ADKIQIFKLY KSSL
//
