GenomeNet

Database: UniProt
Entry: B4KGB7_DROMO
LinkDB: B4KGB7_DROMO
Original site: B4KGB7_DROMO 
ID   B4KGB7_DROMO            Unreviewed;       759 AA.
AC   B4KGB7;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 2.
DT   16-OCT-2019, entry version 80.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EDW11104.2};
GN   Name=Dmoj\GI16971 {ECO:0000313|EMBL:EDW11104.2};
GN   ORFNames=Dmoj_GI16971 {ECO:0000313|EMBL:EDW11104.2};
OS   Drosophila mojavensis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila.
OX   NCBI_TaxID=7230 {ECO:0000313|EMBL:EDW11104.2, ECO:0000313|Proteomes:UP000009192};
RN   [1] {ECO:0000313|EMBL:EDW11104.2, ECO:0000313|Proteomes:UP000009192}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15081-1352.22 {ECO:0000313|Proteomes:UP000009192};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 Genomes Consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
RA   Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
RA   Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
RA   Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
RA   Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
RA   Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
RA   Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
RA   Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
RA   Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
RA   Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
RA   Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
RA   Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
RA   Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
RA   Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
RA   Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
RA   Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
RA   Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
RA   Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
RA   Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
RA   Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
RA   Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
RA   Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
RA   Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
RA   McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
RA   Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
RA   Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
RA   Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
RA   Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
RA   Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
RA   Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
RA   Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
RA   Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
RA   Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
RA   Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
RA   Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
RA   Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
RA   Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
RA   Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
RA   Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
RA   Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
RA   Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
RA   Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
RA   An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
RA   Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
RA   Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
RA   Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
RA   Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
RA   DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
RA   Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
RA   Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
RA   LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
RA   Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
RA   Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
RA   Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
RA   Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
RA   Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
RA   Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
RA   Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
RA   Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
RA   Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004019,
CC       ECO:0000256|SAAS:SAAS00594387}.
CC   -!- SIMILARITY: Belongs to the ETS family.
CC       {ECO:0000256|RuleBase:RU004019, ECO:0000256|SAAS:SAAS00594391}.
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DR   EMBL; CH933807; EDW11104.2; -; Genomic_DNA.
DR   RefSeq; XP_002001662.2; XM_002001626.2.
DR   STRING; 7230.FBpp0166188; -.
DR   EnsemblMetazoa; FBtr0423354; FBpp0381307; FBgn0139717.
DR   GeneID; 6575653; -.
DR   KEGG; dmo:Dmoj_GI16971; -.
DR   InParanoid; B4KGB7; -.
DR   KO; K03211; -.
DR   OrthoDB; 827924at2759; -.
DR   Proteomes; UP000009192; Unassembled WGS sequence.
DR   Bgee; FBgn0139717; Expressed in 2 organ(s), highest expression level in adult organism.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblMetazoa.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:EnsemblMetazoa.
DR   GO; GO:0019904; F:protein domain specific binding; IEA:EnsemblMetazoa.
DR   GO; GO:0000980; F:RNA polymerase II distal enhancer sequence-specific DNA binding; IEA:EnsemblMetazoa.
DR   GO; GO:0007298; P:border follicle cell migration; IEA:EnsemblMetazoa.
DR   GO; GO:0001709; P:cell fate determination; IEA:EnsemblMetazoa.
DR   GO; GO:0008340; P:determination of adult lifespan; IEA:EnsemblMetazoa.
DR   GO; GO:0006897; P:endocytosis; IEA:EnsemblMetazoa.
DR   GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IEA:EnsemblMetazoa.
DR   GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IEA:EnsemblMetazoa.
DR   GO; GO:0008406; P:gonad development; IEA:EnsemblMetazoa.
DR   GO; GO:0048747; P:muscle fiber development; IEA:EnsemblMetazoa.
DR   GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:EnsemblMetazoa.
DR   GO; GO:0035157; P:negative regulation of fusion cell fate specification; IEA:EnsemblMetazoa.
DR   GO; GO:0045677; P:negative regulation of R7 cell differentiation; IEA:EnsemblMetazoa.
DR   GO; GO:0035155; P:negative regulation of terminal cell fate specification, open tracheal system; IEA:EnsemblMetazoa.
DR   GO; GO:0060233; P:oenocyte delamination; IEA:EnsemblMetazoa.
DR   GO; GO:1903688; P:positive regulation of border follicle cell migration; IEA:EnsemblMetazoa.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:EnsemblMetazoa.
DR   GO; GO:0007464; P:R3/R4 cell fate commitment; IEA:EnsemblMetazoa.
DR   GO; GO:0090175; P:regulation of establishment of planar polarity; IEA:EnsemblMetazoa.
DR   GO; GO:0045500; P:sevenless signaling pathway; IEA:EnsemblMetazoa.
DR   GO; GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IEA:EnsemblMetazoa.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR033077; Pokkuri.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11849:SF201; PTHR11849:SF201; 1.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009192};
KW   DNA-binding {ECO:0000256|RuleBase:RU004019,
KW   ECO:0000256|SAAS:SAAS00594397};
KW   Nucleus {ECO:0000256|RuleBase:RU004019,
KW   ECO:0000256|SAAS:SAAS00594400};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009192}.
FT   DOMAIN       33    117       PNT. {ECO:0000259|PROSITE:PS51433}.
FT   DOMAIN      401    484       ETS. {ECO:0000259|PROSITE:PS50061}.
FT   REGION      133    169       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      184    211       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      241    312       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      501    553       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      693    759       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COILED      327    361       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS    137    153       Pro-rich. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS    187    211       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS    241    272       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS    501    548       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS    715    741       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   759 AA;  81905 MW;  6BC70E09E88072B8 CRC64;
     MSKMKMLPVQ LSLNPLNPGI WGDVMWRCPP PPSSQLAELK TQLPPSLPSD PRLWSRDDVL
     VFLRFCVREF DLPKLDFDLF QMNGKALCLL TRTDFGHRCP GAGDVLHNVL QMLIIESHMM
     QWHLPNSPVT PTGRYPLSPH SHPPTPTWPP LNAPPGADTG GSSNPFHSSS SVAAHMAAHH
     FMAPNSVTLS PPPSVDSQAS SPPESASGYS SAGASAAAMS SAVAAAAAAA AAAAAAVAGS
     SSASSTTSNG STLNGCVQPM KGIQSSASSN HSDSEEEFAD NTNSNNKALP LAPLSYSAGS
     PPGTPIHKDM KPNWTQQLTN SFVSSWSQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQKLTLEN
     AAGAIVAAGG GSISAPTTPS YMYKAKREFF PENSEPNTNG RLLWDFLQQL LNDRNQKYSD
     LIAWKCRDTG VFKIVDPAGL AKLWGIQKNH LSMNYDKMSR ALRYYYRVNI LRKVQGERHC
     YQFLRNPTEL KNIKNISQLR QTATASATPG EQVGSASASS WSQQQQQQQQ QQLQQQQQSP
     QRPASRNAQP MALPTAAAVA AAAAAAGYGP QPTSPLFMHA FHFLSAAAAA PPPNSPGSVA
     CLTPGAATSA PGDKFQFHPL KLESANDSAG EDLKPTDLSV SSKTANANAN ANANANANGN
     ANANLNEDCY PLLRNADGLT TIKLIRQSEH KAEASEQLTA AAGGSHSAAN SPRPMDAVER
     ERERERERER EREREREPQA VPMDSECNGS EEAAFRHMH
//
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