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Database: UniProt
Entry: B4KHL5
LinkDB: B4KHL5
Original site: B4KHL5 
ID   RAD54_DROMO             Reviewed;         783 AA.
AC   B4KHL5;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   16-OCT-2019, entry version 55.
DE   RecName: Full=DNA repair and recombination protein RAD54-like {ECO:0000250|UniProtKB:O76460};
DE            EC=3.6.4.-;
DE   AltName: Full=Protein okra {ECO:0000250|UniProtKB:O76460};
GN   Name=okr {ECO:0000250|UniProtKB:O76460}; ORFNames=GI10760;
OS   Drosophila mojavensis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila.
OX   NCBI_TaxID=7230;
RN   [1] {ECO:0000312|EMBL:EDW12294.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15081-1352.22 {ECO:0000312|EMBL:EDW12294.1};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Involved in mitotic DNA repair and meiotic
CC       recombination. Functions in the recombinational DNA repair
CC       pathway. Essential for interhomolog gene conversion (GC), but may
CC       have a less important role in intersister GC than spn-A/Rad51. In
CC       the presence of DNA, spn-A/Rad51 enhances the ATPase activity of
CC       okr/Rad54 (By similarity). {ECO:0000250|UniProtKB:O76460}.
CC   -!- SUBUNIT: Interacts (via N-terminus) with spn-A/Rad51.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O76460}.
CC   -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family.
CC       {ECO:0000255}.
DR   EMBL; CH933807; EDW12294.1; -; Genomic_DNA.
DR   RefSeq; XP_002002852.1; XM_002002816.2.
DR   SMR; B4KHL5; -.
DR   STRING; 7230.FBpp0159977; -.
DR   PRIDE; B4KHL5; -.
DR   EnsemblMetazoa; FBtr0161485; FBpp0159977; FBgn0133523.
DR   GeneID; 6576868; -.
DR   KEGG; dmo:Dmoj_GI10760; -.
DR   InParanoid; B4KHL5; -.
DR   KO; K10875; -.
DR   OMA; GMVICDE; -.
DR   OrthoDB; 93727at2759; -.
DR   PhylomeDB; B4KHL5; -.
DR   ChiTaRS; okr; fly.
DR   Proteomes; UP000009192; Unassembled WGS sequence.
DR   Bgee; FBgn0133523; Expressed in 1 organ(s), highest expression level in adult organism.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0006338; P:chromatin remodeling; ISS:UniProtKB.
DR   GO; GO:0043150; P:DNA synthesis involved in double-strand break repair via homologous recombination; ISS:UniProtKB.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; ISS:UniProtKB.
DR   GO; GO:0000711; P:meiotic DNA repair synthesis; ISS:UniProtKB.
DR   GO; GO:0010212; P:response to ionizing radiation; ISS:UniProtKB.
DR   Gene3D; 3.40.50.10810; -; 1.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR013967; Rad54_N.
DR   InterPro; IPR038718; SNF2-like_sf.
DR   InterPro; IPR000330; SNF2_N.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF08658; Rad54_N; 1.
DR   Pfam; PF00176; SNF2_N; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cell cycle; Cell division; Complete proteome; DNA damage;
KW   DNA repair; DNA-binding; Helicase; Hydrolase; Meiosis; Mitosis;
KW   Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN         1    783       DNA repair and recombination protein
FT                                RAD54-like.
FT                                /FTId=PRO_0000392523.
FT   DOMAIN      165    340       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      497    654       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     178    185       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   REGION        2      9       Required for chromatin remodeling, strand
FT                                pairing activities and coupling of ATPase
FT                                activity. {ECO:0000250|UniProtKB:O76460}.
FT   MOTIF       291    294       DEGH box. {ECO:0000255}.
FT   MOD_RES      22     22       Phosphothreonine.
FT                                {ECO:0000250|UniProtKB:O76460}.
SQ   SEQUENCE   783 AA;  89247 MW;  D122BA835CC26755 CRC64;
     MRRSLAPSQR LGVRIKSKDA FTPPLQKKNK RVCQEELQKR QSALRDATNR VELPLPIRFT
     ANSEYEQAIA KVLARKFKVP IANYVPDYGG NRTLGVRRTI VRRALHDPQA CNALVLYVPP
     AYTEHERMSM DPSKVQVHVV VDPILSNVLR PHQREGVRFM YECVEGKRGN FNGCIMADEM
     GLGKTLQCVT LTWTLLRQSP DCKPTISKAI IVSPSSLVKN WEKEFTKWLH GRMHCLAMEG
     GSKEDTTRAL EQFAMNTATR CGTPVLLISY ETFRLYAHIL CKTEVGMVIC DEGHRLKNSD
     NLTYQALMGL KTKRRVLLSG TPIQNDLTEY FSLVNFVNPE MLGTAADFKR NFENSILRGQ
     NADSTDAERQ RALQKTQELI GLVNQCIIRR TNQILTKYLP VKFEMVVCVK LTPVQLQIYT
     NFLKSDQVRR SLADCNEKAS LTALADITTL KKLCNHPDLI YEKIAAKEKG FENSQNVLPP
     NYKPKDVNPE LSGKFMLLDF MLAAIRANSD DKVVLISNYT QTLDLFEQLA RKRKYTYVRL
     DGTMTIKKRS KVVDRFNDPS TDCFLFMLSS KAGGCGLNLI GANRLFMFDP DWNPANDEQA
     MARVWRDGQK KPCYIYRLVA SGSIEEKILQ RQTHKKSLSS TIIDNNESSE KHFTRDDLKD
     LFSFEANVLS DTHNKLKCKR CFQDVQRQPP AENTDCTSHL SQWFHCSNNR GLPDSILSQA
     WTASKCVSFV FHHRSQAESK PAAITEDDES EQQQQSPKRT SKNDDNDEDF DPENSAEEQF
     LGF
//
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