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Database: UniProt
Entry: B4KQ41_DROMO
LinkDB: B4KQ41_DROMO
Original site: B4KQ41_DROMO 
ID   B4KQ41_DROMO            Unreviewed;      1297 AA.
AC   B4KQ41;
DT   23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   23-SEP-2008, sequence version 1.
DT   31-JUL-2019, entry version 68.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EDW08143.1};
DE            EC=3.1.26.3 {ECO:0000313|EMBL:EDW08143.1};
GN   Name=Dmoj\GI19789 {ECO:0000313|EMBL:EDW08143.1};
GN   ORFNames=Dmoj_GI19789 {ECO:0000313|EMBL:EDW08143.1};
OS   Drosophila mojavensis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila.
OX   NCBI_TaxID=7230 {ECO:0000313|EMBL:EDW08143.1, ECO:0000313|Proteomes:UP000009192};
RN   [1] {ECO:0000313|EMBL:EDW08143.1, ECO:0000313|Proteomes:UP000009192}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15081-1352.22 {ECO:0000313|Proteomes:UP000009192};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 Genomes Consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
RA   Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
RA   Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
RA   Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
RA   Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
RA   Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
RA   Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
RA   Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
RA   Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
RA   Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
RA   Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
RA   Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
RA   Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
RA   Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
RA   Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
RA   Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
RA   Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
RA   Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
RA   Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
RA   Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
RA   Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
RA   Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
RA   Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
RA   McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
RA   Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
RA   Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
RA   Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
RA   Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
RA   Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
RA   Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
RA   Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
RA   Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
RA   Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
RA   Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
RA   Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
RA   Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
RA   Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
RA   Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
RA   Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
RA   Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
RA   Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
RA   Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
RA   An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
RA   Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
RA   Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
RA   Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
RA   Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
RA   DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
RA   Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
RA   Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
RA   LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
RA   Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
RA   Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
RA   Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
RA   Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
RA   Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
RA   Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
RA   Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
RA   Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
RA   Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
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DR   EMBL; CH933808; EDW08143.1; -; Genomic_DNA.
DR   RefSeq; XP_002004208.1; XM_002004172.2.
DR   SMR; B4KQ41; -.
DR   STRING; 7230.FBpp0169006; -.
DR   EnsemblMetazoa; FBtr0170514; FBpp0169006; FBgn0142526.
DR   GeneID; 6578293; -.
DR   KEGG; dmo:Dmoj_GI19789; -.
DR   InParanoid; B4KQ41; -.
DR   KO; K03685; -.
DR   OMA; EYLYRHF; -.
DR   OrthoDB; 935825at2759; -.
DR   PhylomeDB; B4KQ41; -.
DR   Proteomes; UP000009192; Unassembled WGS sequence.
DR   Bgee; FBgn0142526; Expressed in 2 organ(s), highest expression level in head.
DR   GO; GO:0070877; C:microprocessor complex; IEA:EnsemblMetazoa.
DR   GO; GO:0004525; F:ribonuclease III activity; IEA:UniProtKB-EC.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0030727; P:germarium-derived female germ-line cyst formation; IEA:EnsemblMetazoa.
DR   GO; GO:0007294; P:germarium-derived oocyte fate determination; IEA:EnsemblMetazoa.
DR   GO; GO:0016319; P:mushroom body development; IEA:EnsemblMetazoa.
DR   GO; GO:0031053; P:primary miRNA processing; IEA:EnsemblMetazoa.
DR   GO; GO:0016075; P:rRNA catabolic process; IEA:InterPro.
DR   GO; GO:0035070; P:salivary gland histolysis; IEA:EnsemblMetazoa.
DR   CDD; cd00048; DSRM; 1.
DR   CDD; cd00593; RIBOc; 2.
DR   Gene3D; 1.10.1520.10; -; 3.
DR   HAMAP; MF_00104; RNase_III; 1.
DR   InterPro; IPR014720; dsRBD_dom.
DR   InterPro; IPR011907; RNase_III.
DR   InterPro; IPR000999; RNase_III_dom.
DR   InterPro; IPR036389; RNase_III_sf.
DR   Pfam; PF00035; dsrm; 1.
DR   Pfam; PF14622; Ribonucleas_3_3; 1.
DR   Pfam; PF00636; Ribonuclease_3; 1.
DR   SMART; SM00358; DSRM; 1.
DR   SMART; SM00535; RIBOc; 2.
DR   SUPFAM; SSF69065; SSF69065; 2.
DR   PROSITE; PS50137; DS_RBD; 1.
DR   PROSITE; PS00517; RNASE_3_1; 1.
DR   PROSITE; PS50142; RNASE_3_2; 2.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000009192};
KW   Hydrolase {ECO:0000313|EMBL:EDW08143.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009192};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266}.
FT   DOMAIN      703    883       RNase III. {ECO:0000259|PROSITE:PS50142}.
FT   DOMAIN      935   1058       RNase III. {ECO:0000259|PROSITE:PS50142}.
FT   DOMAIN     1085   1160       DRBM. {ECO:0000259|PROSITE:PS50137}.
FT   REGION        1     49       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION      117    146       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1175   1297       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS      1     27       Pro-rich. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS   1180   1223       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS   1254   1271       Polar. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   1297 AA;  149034 MW;  C2DB72AD857EDECB CRC64;
     MYQPPLPPPQ DVPTQPPPPP PPAEAIELPP TGLTHDGQPV NIEAPPPTNF DYAQHPWSVN
     DAYNSQGSSM NYGKYDATAY APYAAAPPPP PTYSANAAPY YYGNYGYPES YAAPPSNYGA
     KPSSSGYDSR SDYRQGNYSY NYRPPSHNYY PNNYQKNYGG YNYNNRYEQR YYNPRQSYHA
     NQRIPKSMPN EAANTPKMET ERDRLLRQWC SNYCEKSEDY IKKMNALIEA EAPAESWVRS
     SPAELYYERT KTEHEVRAKP RLHKRCELFQ QQLIERAERV RKTLPVYVPP ARKTRRRACN
     HKHKSEACSS SSDSDSDEDA FKIEQDCCME ELSRKMEHPQ RLHSDLWHND AGEMNDGPLC
     RCSAKSRRIG IRHGIYPGEK GYPLCDKDTN NASKLFHYRI TISPPTNFLT KTPTIIKHDE
     HEFLFEGFSL LSHVRLTDLP VCKVIRFNIE YTIEYDEEKM PENFTIRELD LFFKYLFHEL
     LELVDFNLMP NVEQSCPAFH FLPRFVRELP DNGKEVLAMC EVLKYLLDNS AELVEPQQLQ
     HLNDISQHEW QKYVDYIKGM LVTKPGYKPC SLRVDQLDRN NSDLPECLDR EKGISHPAIV
     HFGIRPPQLS YAGNPEYQKA WREYVKFRHL MANMSKPSFK DKRKLEDKEQ RLQEMRTQGR
     MKRNITVAIS SEGFYRTGIM CDIVQHAMLI PVLTGHLRFH KSLDLLEESI GYKFKNRYLL
     QLALTHPSYK ENYGTNPDHA RNSLTNCGIR QPEYGDRKIH YMNTRKRGIN TLVSIMSRFG
     KDHETVSNIT HNERLEFLGD AVVEFLSSIH LFFMFPELEE GGLATYRAAI VQNQHLALLA
     KKLQLEEFML YAHGSDLCHE LELRHAMANC FEALMGALLL DGGIKVADEV FTDALFRQDD
     KLLAIWKNLP EHPLQEQEPL GDRSCIDAYR VLKDLTRFED SIGIKFKHIR LLARAFTDRS
     IGFTHLTLGS NQRLEFLGDT VLQLICSEYL YRHFPEHHEG HLSLLRSSLV NNRTQAVVCD
     DLGMPKFAVY ANPKADLKTK DRADLLEAFL GALYVDKGLL YCEQFCHVCL FPRLQLFIMN
     QDWNDPKSKL QQCCLTLRTM DGGEPDIPYY KVVEASGPTN TRVYKVAVYF RSKRLATASG
     SSIQQAEMNA AKQALENSRD LFPQLDHQKR VIAKSIKKQT GSEMDNDVDK ANDDKVKKPK
     YAAPLEDESH LPKQYRMHEN ISSDELPEDD DEDDQGRATS PVHLPKHRKG SRSRSSSSSS
     SSSSSRSDTD SDTCTTPKRR ARQEDGSVSP VSSSSSL
//
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