ID B4KUK6_DROMO Unreviewed; 1492 AA.
AC B4KUK6;
DT 23-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Uncharacterized protein, isoform A {ECO:0000313|EMBL:EDW18234.1};
DE SubName: Full=Uncharacterized protein, isoform B {ECO:0000313|EMBL:KRG06076.1};
GN Name=Dmoj\GI13126 {ECO:0000313|EMBL:EDW18234.1};
GN ORFNames=Dmoj_GI13126 {ECO:0000313|EMBL:EDW18234.1};
OS Drosophila mojavensis (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=7230 {ECO:0000313|EMBL:EDW18234.1, ECO:0000313|Proteomes:UP000009192};
RN [1] {ECO:0000313|EMBL:EDW18234.1, ECO:0000313|Proteomes:UP000009192}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TSC#15081-1352.22 {ECO:0000313|EMBL:EDW18234.1}, and Tucson
RC 15081-1352.22 {ECO:0000313|Proteomes:UP000009192};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
RN [2] {ECO:0000313|EMBL:EDW18234.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=TSC#15081-1352.22 {ECO:0000313|EMBL:EDW18234.1};
RX PubMed=18057021; DOI=10.1093/bioinformatics/btm542;
RA Zimin A.V., Smith D.R., Sutton G., Yorke J.A.;
RT "Assembly reconciliation.";
RL Bioinformatics 24:42-45(2008).
RN [3] {ECO:0000313|EMBL:EDW18234.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=TSC#15081-1352.22 {ECO:0000313|EMBL:EDW18234.1};
RG FlyBase;
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CH933809; EDW18234.1; -; Genomic_DNA.
DR EMBL; CH933809; KRG06076.1; -; Genomic_DNA.
DR RefSeq; XP_002007758.1; XM_002007722.2.
DR RefSeq; XP_015017728.1; XM_015162242.1.
DR SMR; B4KUK6; -.
DR EnsemblMetazoa; FBtr0163851; FBpp0162343; FBgn0135883.
DR EnsemblMetazoa; FBtr0432403; FBpp0389608; FBgn0135883.
DR KEGG; dmo:Dmoj_GI13126; -.
DR eggNOG; KOG2956; Eukaryota.
DR HOGENOM; CLU_005060_0_0_1; -.
DR InParanoid; B4KUK6; -.
DR OMA; LMEHKVQ; -.
DR OrthoDB; 5478662at2759; -.
DR Proteomes; UP000009192; Unassembled WGS sequence.
DR GO; GO:0005813; C:centrosome; IEA:EnsemblMetazoa.
DR GO; GO:0070938; C:contractile ring; IEA:EnsemblMetazoa.
DR GO; GO:0045169; C:fusome; IEA:EnsemblMetazoa.
DR GO; GO:0045172; C:germline ring canal; IEA:EnsemblMetazoa.
DR GO; GO:0030426; C:growth cone; IEA:EnsemblMetazoa.
DR GO; GO:0000776; C:kinetochore; IEA:EnsemblMetazoa.
DR GO; GO:0005875; C:microtubule associated complex; IEA:EnsemblMetazoa.
DR GO; GO:0035371; C:microtubule plus-end; IEA:EnsemblMetazoa.
DR GO; GO:0031965; C:nuclear membrane; IEA:EnsemblMetazoa.
DR GO; GO:0005827; C:polar microtubule; IEA:EnsemblMetazoa.
DR GO; GO:0045170; C:spectrosome; IEA:EnsemblMetazoa.
DR GO; GO:0070732; C:spindle envelope; IEA:EnsemblMetazoa.
DR GO; GO:0005525; F:GTP binding; IEA:EnsemblMetazoa.
DR GO; GO:0008017; F:microtubule binding; IEA:EnsemblMetazoa.
DR GO; GO:0051315; P:attachment of mitotic spindle microtubules to kinetochore; IEA:EnsemblMetazoa.
DR GO; GO:0007411; P:axon guidance; IEA:EnsemblMetazoa.
DR GO; GO:0007282; P:cystoblast division; IEA:EnsemblMetazoa.
DR GO; GO:0040001; P:establishment of mitotic spindle localization; IEA:EnsemblMetazoa.
DR GO; GO:0035099; P:hemocyte migration; IEA:EnsemblMetazoa.
DR GO; GO:0090307; P:mitotic spindle assembly; IEA:EnsemblMetazoa.
DR GO; GO:0000022; P:mitotic spindle elongation; IEA:EnsemblMetazoa.
DR GO; GO:0016325; P:oocyte microtubule cytoskeleton organization; IEA:EnsemblMetazoa.
DR GO; GO:0030723; P:ovarian fusome organization; IEA:EnsemblMetazoa.
DR GO; GO:0031116; P:positive regulation of microtubule polymerization; IEA:EnsemblMetazoa.
DR GO; GO:0046602; P:regulation of mitotic centrosome separation; IEA:EnsemblMetazoa.
DR GO; GO:0019827; P:stem cell population maintenance; IEA:EnsemblMetazoa.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 4.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR034085; TOG.
DR InterPro; IPR048491; XMAP215_CLASP_TOG.
DR PANTHER; PTHR21567; CLASP; 1.
DR Pfam; PF21040; CEP104-like_TOG; 1.
DR Pfam; PF12348; CLASP_N; 1.
DR Pfam; PF21041; XMAP215_CLASP_TOG; 1.
DR SMART; SM01349; TOG; 4.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Reference proteome {ECO:0000313|Proteomes:UP000009192};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 2..234
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 310..546
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 843..1083
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT DOMAIN 1249..1479
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 1416..1454
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REGION 533..577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 613..745
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 758..779
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1079..1129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1176..1230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 539..577
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 613..674
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 699..713
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 722..745
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1492 AA; 165713 MW; 82DD514542906D8E CRC64;
MAYRKPSDLD GFIQQMPKAD MRVKVQLAED LVTFLSDDTN SIVCTDMGFL IDNLMPWLTG
SHFKIAQKSL EAFSELIKRL GSDFNAYTAT VLPHVIDRLG DSRDTVREKA QLLLRDLMEH
KVQSPQTLID KLAVTCFKHK NAKVREEFLQ TIVNALNEYG TQQLSVRVYI APVCALLGDP
TVNVREAAIQ TLVEIYKHVG DRLRPDLRRI EDMPASKLAL LEQKFDQVKL EGLLLPSALR
NGTNGSGLDE GDNISVRERP TKIVKRQLHS ASSMQRQKPT TNDVAGDAGA VTMEIFEASF
EQVPQLTIFH AKDMDDIYKQ ILVIISDKNA DWEKRVDAFK KVRALLMLNY QAQQQFMTVQ
LKELSLAFLD VLKEELRSQV IREACITIAY MSKTLRNKLD SFCWSILEQL IQLIQNSAKV
IASASTLALK YIIKYTHAPK LLKIYLETLQ QSKSKDIRST LCELMVLLFE EWQTKSLERH
AIILRDTLKK SIGDADSEAR RHSRLAYWAF RRHFPDLADQ IYGSLDIAAQ RALERERDGG
STSSNGGVQQ RPVAPSRIGR STTNSLQKAT PSMRSISAVD TAAAQRAKAR AQYTLYSRQK
KPAVAVTNSN LHAGSATSSS ASGGSLPRPR LNSNSGHQNV SPGTVTPTTR IGRTRAGVSQ
SQPGSRSTSP STKLRDHYGM GGYFRGGATG AIPKKASGIP RSTASSRETS PSRLGSGGGL
MKRSIYSTSS SARRTPERNN PVRTTAASRL LAQSREAELS LGGGSGGNPG DGDMPDYVSG
DFMRSGGIRM GRKLLGRDES DDIDSEASSV CSERSFDSSY TRGNNSMSNY SLSGSRNRLD
WNTQRAPFDD IETIIQYCAS THWGERKDGL ISLTQYLADG KELTQQQLQC VLDMFRKMFM
DTHTKVYSLF LDTVTELILV HAPELHDWLF ILLTRLFNKL GTDLLNSMHS KIWKTLQVVH
EYFPTQLQLK ELFRIISDNT QTPTTKTRIA ILRFLAELVN TYGKSSDFPS DQNQSCERTI
LKLAQMAGDH KSMELRSQAR QCLVALYNLN TPQMTKMLAA LPKGYQDTAR LCIQSNIRRQ
SSGANSPSSS PLSSSSPKPL QSPSVGPFSS LNMHMNSSPR SRQSSVEQEV NYSFSELEVQ
HNIQKTSEEI RSCFAGGQYQ SLAPNGYNGH HLQFAMDQQQ QHQQSGRDLT AQQDSLSSNS
KTQSSANTTQ SNTPESATMR LDTTAPPAQP SSKISLLVAE NGELILPGNL LESEVMRVAL
TLNKDQPVEQ LQTTLTNLGI CIRGGNCELP NKHFKSIMRM LLHMLEAEHT DVIIAGLHVL
SKIVRSDKMR HNWLNFLELI LLKIMNCYQH SKEALREIDT MIPRIAPALP LDLTINIVNP
VIATGAFPAN LCAIKILLEV TEQHGTEITD AHLDTVFPNL ARSADDLQSM VRKAAVFCIV
KLYLVLGEEK LKPKLAVMNP SKVRLLNVYI EKQRNSNSAG GSTKNSSAAS SS
//
